Project

avrg: GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for Trp73

Z-value: 0.93

Motif logo

logo of

Transcription factors associated with Trp73

Gene Symbol Gene ID Gene Info
Trp73
ENSMUSG00000029026.18 transformation related protein 73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp73mm39_v1_chr4_-_154181562_154181630-0.672.2e-01Click!

Activity profile of Trp73 motif

Sorted Z-values of Trp73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_32246489 1.55 ENSMUST00000093207.4
Hba-a2
hemoglobin alpha, adult chain 2
chr11_+_32233511 1.36 ENSMUST00000093209.4
Hba-a1
hemoglobin alpha, adult chain 1
chr9_+_108539296 0.58 ENSMUST00000035222.6
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr17_+_29309942 0.41 ENSMUST00000119901.9
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr4_-_87724533 0.32 ENSMUST00000126353.8
ENSMUST00000149357.8
Mllt3
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr7_-_140462187 0.29 ENSMUST00000211179.2
Sirt3
sirtuin 3
chr2_+_127112127 0.26 ENSMUST00000110375.9
Stard7
START domain containing 7
chr2_+_150751475 0.26 ENSMUST00000028948.5
Gins1
GINS complex subunit 1 (Psf1 homolog)
chr19_-_47126719 0.25 ENSMUST00000140512.8
ENSMUST00000035822.2
Calhm2
calcium homeostasis modulator family member 2
chr4_-_87724512 0.25 ENSMUST00000148059.2
Mllt3
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr1_-_170042947 0.25 ENSMUST00000027979.14
ENSMUST00000123399.2
Uhmk1
U2AF homology motif (UHM) kinase 1
chr13_-_55169100 0.24 ENSMUST00000148221.8
ENSMUST00000052949.13
Hk3
hexokinase 3
chr13_-_55169000 0.24 ENSMUST00000153665.8
Hk3
hexokinase 3
chr2_-_164699462 0.23 ENSMUST00000109316.8
ENSMUST00000156255.8
ENSMUST00000128110.2
ENSMUST00000109317.10
ENSMUST00000059954.14
Pltp
phospholipid transfer protein
chr9_+_121245036 0.23 ENSMUST00000211187.2
Trak1
trafficking protein, kinesin binding 1
chr7_-_140462221 0.22 ENSMUST00000026559.14
Sirt3
sirtuin 3
chr7_+_127344942 0.21 ENSMUST00000189562.7
ENSMUST00000186116.7
Fbxl19
F-box and leucine-rich repeat protein 19
chr7_-_141023199 0.21 ENSMUST00000106005.9
Pidd1
p53 induced death domain protein 1
chr9_-_44624496 0.19 ENSMUST00000144251.8
ENSMUST00000156918.8
Phldb1
pleckstrin homology like domain, family B, member 1
chr15_-_98505508 0.19 ENSMUST00000096224.6
Adcy6
adenylate cyclase 6
chr8_+_27575611 0.19 ENSMUST00000178514.8
ENSMUST00000033876.14
Adgra2
adhesion G protein-coupled receptor A2
chr7_+_140462343 0.18 ENSMUST00000163610.9
ENSMUST00000164681.8
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr3_-_107838895 0.17 ENSMUST00000133947.9
ENSMUST00000124215.2
ENSMUST00000106688.8
ENSMUST00000106687.9
Gstm7
glutathione S-transferase, mu 7
chr9_-_42383494 0.17 ENSMUST00000128959.8
ENSMUST00000066148.12
ENSMUST00000138506.8
Tbcel
tubulin folding cofactor E-like
chr14_-_52341426 0.17 ENSMUST00000227536.2
ENSMUST00000227195.2
ENSMUST00000228815.2
ENSMUST00000228198.2
ENSMUST00000227458.2
ENSMUST00000228232.2
ENSMUST00000227242.2
ENSMUST00000228748.2
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr2_+_160573178 0.14 ENSMUST00000103115.8
Plcg1
phospholipase C, gamma 1
chr3_-_89152320 0.14 ENSMUST00000107464.8
ENSMUST00000090924.13
Trim46
tripartite motif-containing 46
chr16_-_16942970 0.14 ENSMUST00000093336.8
ENSMUST00000231681.2
2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr10_-_57408512 0.14 ENSMUST00000169122.8
Serinc1
serine incorporator 1
chr6_-_83031358 0.14 ENSMUST00000113962.8
ENSMUST00000089645.13
ENSMUST00000113963.8
Htra2
HtrA serine peptidase 2
chr8_-_71112295 0.13 ENSMUST00000211715.2
ENSMUST00000210307.2
ENSMUST00000209768.2
ENSMUST00000070173.9
Pgpep1
pyroglutamyl-peptidase I
chr11_-_76359222 0.13 ENSMUST00000065028.14
Abr
active BCR-related gene
chr1_+_185095232 0.13 ENSMUST00000046514.13
Eprs
glutamyl-prolyl-tRNA synthetase
chr7_+_140461860 0.13 ENSMUST00000026560.14
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chrX_-_10083157 0.13 ENSMUST00000072393.9
ENSMUST00000044598.13
ENSMUST00000073392.11
ENSMUST00000115533.8
ENSMUST00000115532.2
Rpgr
retinitis pigmentosa GTPase regulator
chr2_+_160573604 0.13 ENSMUST00000174885.2
ENSMUST00000109462.8
Plcg1
phospholipase C, gamma 1
chr11_-_102120953 0.12 ENSMUST00000107150.8
ENSMUST00000156337.2
ENSMUST00000107151.9
ENSMUST00000107152.9
Hdac5
histone deacetylase 5
chr15_+_30172716 0.11 ENSMUST00000081728.7
Ctnnd2
catenin (cadherin associated protein), delta 2
chr7_+_101732323 0.11 ENSMUST00000124189.3
Trpc2
transient receptor potential cation channel, subfamily C, member 2
chr2_+_59442378 0.11 ENSMUST00000112568.8
ENSMUST00000037526.11
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr11_-_102120917 0.11 ENSMUST00000008999.12
Hdac5
histone deacetylase 5
chr7_-_4517367 0.11 ENSMUST00000166161.8
Tnnt1
troponin T1, skeletal, slow
chr1_-_55127183 0.10 ENSMUST00000027123.15
Hspd1
heat shock protein 1 (chaperonin)
chr10_-_105677184 0.10 ENSMUST00000046638.10
Mettl25
methyltransferase like 25
chr11_+_60030891 0.10 ENSMUST00000171108.8
ENSMUST00000090806.5
Rai1
retinoic acid induced 1
chr3_+_159545309 0.09 ENSMUST00000068952.10
ENSMUST00000198878.2
Wls
wntless WNT ligand secretion mediator
chr11_+_98632953 0.09 ENSMUST00000153043.8
Thra
thyroid hormone receptor alpha
chr17_+_28910714 0.08 ENSMUST00000233250.2
Mapk14
mitogen-activated protein kinase 14
chr6_-_29212239 0.08 ENSMUST00000160878.8
Impdh1
inosine monophosphate dehydrogenase 1
chr2_-_39080701 0.07 ENSMUST00000142872.2
ENSMUST00000038874.12
Scai
suppressor of cancer cell invasion
chr19_-_7460550 0.07 ENSMUST00000088169.7
Rtn3
reticulon 3
chr1_-_55127312 0.07 ENSMUST00000127861.8
ENSMUST00000144077.3
Hspd1
heat shock protein 1 (chaperonin)
chr11_-_103235475 0.07 ENSMUST00000041385.14
Arhgap27
Rho GTPase activating protein 27
chr12_+_111540920 0.07 ENSMUST00000075281.8
ENSMUST00000084953.13
Mark3
MAP/microtubule affinity regulating kinase 3
chr5_+_137286535 0.06 ENSMUST00000024099.11
ENSMUST00000196208.5
ENSMUST00000085934.4
Ache
acetylcholinesterase
chr5_-_31117617 0.06 ENSMUST00000202567.2
ENSMUST00000074840.12
Preb
prolactin regulatory element binding
chr6_-_29212295 0.06 ENSMUST00000078155.12
Impdh1
inosine monophosphate dehydrogenase 1
chr18_+_56565188 0.05 ENSMUST00000070166.6
Gramd3
GRAM domain containing 3
chr2_-_114031897 0.05 ENSMUST00000050668.4
Zfp770
zinc finger protein 770
chr5_+_64960705 0.05 ENSMUST00000165536.8
Klf3
Kruppel-like factor 3 (basic)
chr11_+_75546989 0.05 ENSMUST00000136935.2
Myo1c
myosin IC
chr10_+_115854118 0.04 ENSMUST00000063470.11
Ptprr
protein tyrosine phosphatase, receptor type, R
chr10_-_62486948 0.04 ENSMUST00000020270.6
Ddx50
DExD box helicase 50
chr4_+_108857967 0.04 ENSMUST00000106644.9
Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr3_-_89309944 0.03 ENSMUST00000057431.6
Lenep
lens epithelial protein
chr9_+_108815078 0.03 ENSMUST00000052724.5
Ucn2
urocortin 2
chr19_-_7460600 0.02 ENSMUST00000235593.2
ENSMUST00000088171.12
ENSMUST00000065304.13
ENSMUST00000025667.14
Rtn3
reticulon 3
chr7_-_4517608 0.02 ENSMUST00000166959.8
Tnnt1
troponin T1, skeletal, slow
chr12_+_3415143 0.02 ENSMUST00000020999.7
Kif3c
kinesin family member 3C
chr11_-_69838971 0.02 ENSMUST00000179298.3
ENSMUST00000018710.13
ENSMUST00000135437.3
ENSMUST00000141837.9
ENSMUST00000142500.8
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
chr4_-_106662195 0.02 ENSMUST00000065253.13
Acot11
acyl-CoA thioesterase 11
chr8_-_85794611 0.01 ENSMUST00000177563.2
Gm5741
predicted gene 5741
chr2_-_90735171 0.01 ENSMUST00000005647.4
Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
chr6_-_94260806 0.01 ENSMUST00000203519.3
ENSMUST00000204347.3
Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr7_-_30754240 0.01 ENSMUST00000206860.2
ENSMUST00000071697.11
Fxyd1
FXYD domain-containing ion transport regulator 1
chr14_+_53607470 0.01 ENSMUST00000103652.5
Trav14n-3
T cell receptor alpha variable 14N-3
chr4_+_108857803 0.01 ENSMUST00000065977.11
ENSMUST00000102736.9
Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr19_+_46292759 0.00 ENSMUST00000237330.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr1_+_75483721 0.00 ENSMUST00000037330.5
Inha
inhibin alpha
chr1_+_134217727 0.00 ENSMUST00000027730.6
Myog
myogenin

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp73

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.1 0.2 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.1 0.2 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.2 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.2 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.1 0.6 GO:0015879 carnitine transport(GO:0015879)
0.0 2.9 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.2 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.5 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.6 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.6 GO:2000096 segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0051410 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.3 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.5 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.1 GO:0045212 neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.0 0.2 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) stress-induced premature senescence(GO:0090400) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.6 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway