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avrg: GFI1 WT vs 36n/n vs KD

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Results for Twist1

Z-value: 0.35

Motif logo

Transcription factors associated with Twist1

Gene Symbol Gene ID Gene Info
ENSMUSG00000035799.7 twist basic helix-loop-helix transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Twist1mm39_v1_chr12_+_34007645_340076700.029.7e-01Click!

Activity profile of Twist1 motif

Sorted Z-values of Twist1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_126866682 0.29 ENSMUST00000040560.11
Ts translation elongation factor, mitochondrial
chr6_-_124790029 0.22 ENSMUST00000149610.3
triosephosphate isomerase 1
chr9_-_44253630 0.21 ENSMUST00000097558.5
hydroxymethylbilane synthase
chr7_+_82516491 0.20 ENSMUST00000082237.7
mex3 RNA binding family member B
chr6_-_124410452 0.19 ENSMUST00000124998.2
ENSMUST00000238807.2
calsyntenin 3
chr11_+_53661251 0.18 ENSMUST00000138913.8
ENSMUST00000123376.8
ENSMUST00000019043.13
ENSMUST00000133291.3
interferon regulatory factor 1
chr10_+_61010983 0.17 ENSMUST00000143207.8
ENSMUST00000148181.8
ENSMUST00000151886.8
thymus, brain and testes associated
chr17_+_34029484 0.15 ENSMUST00000048560.11
ENSMUST00000172649.8
ENSMUST00000173789.2
KN motif and ankyrin repeat domains 3
chr17_+_74645936 0.15 ENSMUST00000224711.2
ENSMUST00000024869.8
ENSMUST00000233611.2
spastin
chrX_-_100310959 0.14 ENSMUST00000135038.2
interleukin 2 receptor, gamma chain
chr7_-_126817475 0.13 ENSMUST00000106313.8
ENSMUST00000142356.3
septin 1
chr7_-_30814652 0.12 ENSMUST00000168884.8
ENSMUST00000108102.9
hepsin
chr15_+_100251030 0.12 ENSMUST00000075675.7
ENSMUST00000088142.6
ENSMUST00000176287.2
methyltransferase hypoxia inducible domain containing 1
methyltransferase like 7A2
chr15_-_89007290 0.12 ENSMUST00000109353.9
tubulin, gamma complex associated protein 6
chr4_+_132495636 0.12 ENSMUST00000102561.11
replication protein A2
chr8_-_71834543 0.11 ENSMUST00000002466.9
nuclear receptor subfamily 2, group F, member 6
chr17_+_34258411 0.09 ENSMUST00000087497.11
ENSMUST00000131134.9
ENSMUST00000235819.2
ENSMUST00000114255.9
ENSMUST00000114252.9
ENSMUST00000237989.2
collagen, type XI, alpha 2
chr11_+_87628356 0.09 ENSMUST00000093955.12
SPT4A, DSIF elongation factor subunit
chr6_-_83808717 0.09 ENSMUST00000058383.9
poly(A) binding protein interacting protein 2B
chr8_+_53964721 0.09 ENSMUST00000211424.2
ENSMUST00000033920.6
aspartylglucosaminidase
chr9_-_57375269 0.09 ENSMUST00000215059.2
ENSMUST00000046587.8
ENSMUST00000214256.2
secretory carrier membrane protein 5
chr5_-_35886605 0.09 ENSMUST00000070203.14
SH3 domain and tetratricopeptide repeats 1
chr10_-_126866658 0.09 ENSMUST00000120547.2
ENSMUST00000152054.8
Ts translation elongation factor, mitochondrial
chr4_-_57143437 0.08 ENSMUST00000095076.10
ENSMUST00000030142.4
erythrocyte membrane protein band 4.1 like 4b
chr4_-_152122891 0.07 ENSMUST00000030792.2
taste receptor, type 1, member 1
chr3_+_65435825 0.07 ENSMUST00000047906.10
TCDD-inducible poly(ADP-ribose) polymerase
chr2_+_130116357 0.07 ENSMUST00000136621.9
ENSMUST00000141872.2
NOP56 ribonucleoprotein
chr3_+_89958940 0.07 ENSMUST00000159064.8
RIKEN cDNA 4933434E20 gene
chr9_+_60701749 0.07 ENSMUST00000214354.2
ENSMUST00000050183.7
ENSMUST00000217656.2
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_-_4448631 0.07 ENSMUST00000008579.14
retinol dehydrogenase 13 (all-trans and 9-cis)
chr4_-_129452180 0.07 ENSMUST00000067240.11
lymphocyte protein tyrosine kinase
chr9_-_44253588 0.07 ENSMUST00000215091.2
hydroxymethylbilane synthase
chr15_+_100232810 0.07 ENSMUST00000075420.6
methyltransferase like 7A3
chr9_-_83688294 0.06 ENSMUST00000034796.14
ENSMUST00000183614.2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chrX_-_56371953 0.06 ENSMUST00000176986.8
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr15_-_57755753 0.06 ENSMUST00000022993.7
Der1-like domain family, member 1
chr4_-_129452148 0.06 ENSMUST00000167288.8
ENSMUST00000134336.3
lymphocyte protein tyrosine kinase
chr16_+_18245134 0.06 ENSMUST00000205679.3
thioredoxin reductase 2
chr4_-_126362372 0.06 ENSMUST00000097888.10
ENSMUST00000239399.2
argonaute RISC catalytic subunit 1
chr7_+_130179063 0.05 ENSMUST00000207918.2
ENSMUST00000215492.2
ENSMUST00000084513.12
ENSMUST00000059145.14
transforming, acidic coiled-coil containing protein 2
chr7_-_84339045 0.05 ENSMUST00000209165.2
zinc finger, AN1-type domain 6
chr9_+_59564482 0.05 ENSMUST00000216620.2
ENSMUST00000217038.2
pyruvate kinase, muscle
chr11_+_109541400 0.05 ENSMUST00000106676.8
protein kinase, cAMP dependent regulatory, type I, alpha
chr8_-_4309257 0.05 ENSMUST00000053252.9
cortexin 1
chr11_-_82761954 0.05 ENSMUST00000108173.10
ENSMUST00000071152.14
ring finger and FYVE like domain containing protein
chr8_-_78337297 0.05 ENSMUST00000141202.2
ENSMUST00000152168.8
transmembrane protein 184C
chr2_+_29855572 0.05 ENSMUST00000113719.9
ENSMUST00000113717.8
ENSMUST00000113741.8
ENSMUST00000100225.9
ENSMUST00000095083.11
ENSMUST00000046257.14
spectrin alpha, non-erythrocytic 1
chr7_-_126817639 0.04 ENSMUST00000152267.8
ENSMUST00000106314.8
septin 1
chr11_+_109541747 0.04 ENSMUST00000049527.7
protein kinase, cAMP dependent regulatory, type I, alpha
chr13_+_55612050 0.04 ENSMUST00000046533.9
proline rich 7 (synaptic)
chr8_-_106660470 0.04 ENSMUST00000034368.8
chymotrypsin-like
chr7_-_28931873 0.04 ENSMUST00000085818.6
potassium inwardly-rectifying channel, subfamily K, member 6
chr17_-_35978438 0.04 ENSMUST00000043674.15
valyl-tRNA synthetase 2, mitochondrial
chr4_-_135221926 0.04 ENSMUST00000102549.10
NIPA-like domain containing 3
chr9_-_108444561 0.04 ENSMUST00000074208.6
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr17_+_45874800 0.04 ENSMUST00000224905.2
ENSMUST00000226086.2
ENSMUST00000041353.7
solute carrier family 35, member B2
chr7_+_24310171 0.04 ENSMUST00000206422.2
pleckstrin homology like domain, family B, member 3
chr8_-_117809188 0.04 ENSMUST00000109093.9
ENSMUST00000098375.6
polycystic kidney disease 1 like 2
chr6_+_113366207 0.03 ENSMUST00000204026.3
tubulin tyrosine ligase-like family, member 3
chr1_+_171265103 0.03 ENSMUST00000043839.5
F11 receptor
chr17_+_31515962 0.03 ENSMUST00000237932.2
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr9_-_54569128 0.03 ENSMUST00000034822.12
acyl-CoA synthetase bubblegum family member 1
chr19_-_11243530 0.03 ENSMUST00000169159.3
membrane-spanning 4-domains, subfamily A, member 1
chr6_-_29164981 0.02 ENSMUST00000007993.16
RNA binding motif protein 28
chr15_-_100497863 0.02 ENSMUST00000073837.13
POU domain, class 6, transcription factor 1
chr12_-_113945961 0.02 ENSMUST00000103466.2
immunoglobulin heavy variable 11-1
chr4_+_118750282 0.02 ENSMUST00000094830.2
olfactory receptor 1330
chr13_-_104246084 0.02 ENSMUST00000224945.2
ENSMUST00000109315.5
neurolysin (metallopeptidase M3 family)
chr11_+_99748741 0.02 ENSMUST00000107434.2
predicted gene 11568
chr16_+_31482745 0.02 ENSMUST00000100001.10
ENSMUST00000064477.14
discs large MAGUK scaffold protein 1
chr7_-_4448180 0.02 ENSMUST00000138798.2
retinol dehydrogenase 13 (all-trans and 9-cis)
chr9_-_14815228 0.02 ENSMUST00000034409.14
ENSMUST00000117620.8
IZUMO1 receptor, JUNO
chr7_+_30121776 0.02 ENSMUST00000108175.8
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr5_-_23880939 0.02 ENSMUST00000196388.5
serine/arginine-rich protein specific kinase 2
chr11_-_109188892 0.01 ENSMUST00000106706.8
regulator of G-protein signaling 9
chr12_+_102915102 0.01 ENSMUST00000101099.12
unc-79 homolog
chr5_+_8943943 0.01 ENSMUST00000196067.2
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr11_-_109188947 0.01 ENSMUST00000020920.10
regulator of G-protein signaling 9
chr11_+_102993865 0.01 ENSMUST00000152971.2
acyl-Coenzyme A binding domain containing 4
chr11_-_99549786 0.01 ENSMUST00000092695.5
predicted gene 11563
chr7_-_142628298 0.01 ENSMUST00000148715.8
transient receptor potential cation channel, subfamily M, member 5
chr8_+_55024446 0.01 ENSMUST00000239166.2
ENSMUST00000239106.2
ENSMUST00000239152.2
ankyrin repeat and SOCs box-containing 5
chr9_+_118307918 0.01 ENSMUST00000150633.2
eomesodermin
chr6_+_83112793 0.01 ENSMUST00000065512.11
rhotekin
chr11_-_99556781 0.01 ENSMUST00000100476.3
keratin associated protein 4-6
chr19_+_38995463 0.01 ENSMUST00000025966.5
cytochrome P450, family 2, subfamily c, polypeptide 55
chr11_+_99839246 0.01 ENSMUST00000105052.2
keratin associated protein 9-5
chr17_+_21534225 0.00 ENSMUST00000077301.6
vomeronasal 1 receptor 237
chr11_-_99684173 0.00 ENSMUST00000105058.2
predicted gene 11596
chr8_+_106032205 0.00 ENSMUST00000109375.4
ENSMUST00000212033.2
engulfment and cell motility 3
chr6_+_40941688 0.00 ENSMUST00000076638.7
RIKEN cDNA 1810009J06 gene
chr11_-_99689758 0.00 ENSMUST00000105057.2
predicted gene 11569
chr9_-_14815050 0.00 ENSMUST00000148155.2
ENSMUST00000121116.8
IZUMO1 receptor, JUNO
chr7_-_24919247 0.00 ENSMUST00000058702.7
death effector domain-containing DNA binding protein 2
chr6_-_40976413 0.00 ENSMUST00000166306.3
predicted gene 2663
chr16_-_17394080 0.00 ENSMUST00000231552.2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
chr9_-_114673158 0.00 ENSMUST00000047013.4
CKLF-like MARVEL transmembrane domain containing 8
chr9_-_54568950 0.00 ENSMUST00000128624.2
acyl-CoA synthetase bubblegum family member 1
chr15_-_38300937 0.00 ENSMUST00000227920.2
ENSMUST00000074043.7
ENSMUST00000228416.2
Kruppel-like factor 10
chr9_-_14815163 0.00 ENSMUST00000069408.10
IZUMO1 receptor, JUNO
chr2_-_79959802 0.00 ENSMUST00000102653.8
phosphodiesterase 1A, calmodulin-dependent
chrX_-_52203405 0.00 ENSMUST00000114843.9
placental specific protein 1
chr13_+_104246259 0.00 ENSMUST00000160322.8
ENSMUST00000159574.2
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr8_-_112120442 0.00 ENSMUST00000038475.9
fatty acid 2-hydroxylase
chr11_-_99742434 0.00 ENSMUST00000107437.2
keratin associated protein 4-16
chr11_+_69826719 0.00 ENSMUST00000149194.8
Y box protein 2
chr5_+_24569802 0.00 ENSMUST00000115090.6
ENSMUST00000030834.7
nitric oxide synthase 3, endothelial cell
chr2_+_139520098 0.00 ENSMUST00000184404.8
ENSMUST00000099307.4
isthmin 1, angiogenesis inhibitor

Network of associatons between targets according to the STRING database.

First level regulatory network of Twist1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 0.2 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.1 GO:0034769 basement membrane disassembly(GO:0034769)
0.0 0.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.0 0.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.0 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0009644 response to high light intensity(GO:0009644)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.1 GO:0019976 interleukin-2 binding(GO:0019976)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.0 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins