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avrg: GFI1 WT vs 36n/n vs KD

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Results for Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.04

Motif logo

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto

Gene Symbol Gene ID Gene Info
ENSMUSG00000033080.10 visual system homeobox 1
ENSMUSG00000029546.13 UNC homeobox
ENSMUSG00000039476.14 paired related homeobox 2
ENSMUSG00000027833.17 short stature homeobox 2
ENSMUSG00000068302.9 notochord homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Vsx1mm39_v1_chr2_-_150531280_150531280-1.001.5e-04Click!
Shox2mm39_v1_chr3_-_66888474_66888651-0.884.9e-02Click!
Prrx2mm39_v1_chr2_+_30735071_30735071-0.612.8e-01Click!

Activity profile of Vsx1_Uncx_Prrx2_Shox2_Noto motif

Sorted Z-values of Vsx1_Uncx_Prrx2_Shox2_Noto motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_43610829 1.73 ENSMUST00000057110.11
eukaryotic translation initiation factor 3, subunit J2
chr5_+_115373895 1.35 ENSMUST00000081497.13
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
chr3_+_159545309 1.30 ENSMUST00000068952.10
ENSMUST00000198878.2
wntless WNT ligand secretion mediator
chr19_-_24178000 1.29 ENSMUST00000233658.3
tight junction protein 2
chr4_-_154721288 1.09 ENSMUST00000030902.13
ENSMUST00000105637.8
ENSMUST00000070313.14
ENSMUST00000105636.8
ENSMUST00000105638.9
ENSMUST00000097759.9
ENSMUST00000124771.2
PR domain containing 16
chr1_+_40554513 0.90 ENSMUST00000027237.12
interleukin 18 receptor accessory protein
chr14_+_79753055 0.89 ENSMUST00000110835.3
ENSMUST00000227192.2
E74-like factor 1
chr7_-_99512558 0.81 ENSMUST00000207137.2
ENSMUST00000207063.2
ENSMUST00000207580.2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chrX_+_41241049 0.81 ENSMUST00000128799.3
stromal antigen 2
chr14_+_26722319 0.76 ENSMUST00000035433.10
homeobox gene expressed in ES cells
chr10_+_99099084 0.74 ENSMUST00000020118.5
ENSMUST00000220291.2
dual specificity phosphatase 6
chr17_+_46471950 0.72 ENSMUST00000024748.14
ENSMUST00000172170.8
GTP binding protein 2
chr8_-_85389470 0.71 ENSMUST00000060427.6
immediate early response 2
chr3_+_68479578 0.71 ENSMUST00000170788.9
schwannomin interacting protein 1
chr7_-_45480200 0.69 ENSMUST00000107723.9
ENSMUST00000131384.3
glutamate-rich WD repeat containing 1
chr16_-_92196954 0.67 ENSMUST00000023672.10
regulator of calcineurin 1
chr11_+_60428788 0.66 ENSMUST00000044250.4
alkB homolog 5, RNA demethylase
chr15_+_65682066 0.65 ENSMUST00000211878.2
EFR3 homolog A
chr5_+_35156389 0.64 ENSMUST00000114281.8
ENSMUST00000114280.8
regulator of G-protein signaling 12
chr10_+_128173603 0.64 ENSMUST00000005826.9
citrate synthase
chr9_+_113641615 0.63 ENSMUST00000111838.10
ENSMUST00000166734.10
ENSMUST00000214522.2
ENSMUST00000163895.3
CLIP associating protein 2
chr8_+_107757847 0.62 ENSMUST00000034388.10
vacuolar protein sorting 4A
chr5_-_65855511 0.57 ENSMUST00000201948.4
PDS5 cohesin associated factor A
chrX_+_168468186 0.56 ENSMUST00000112107.8
ENSMUST00000112104.8
midline 1
chr3_-_130524024 0.56 ENSMUST00000079085.11
ribosomal protein L34
chr12_+_70499869 0.55 ENSMUST00000021471.13
thioredoxin-related transmembrane protein 1
chr6_+_17749169 0.54 ENSMUST00000053148.14
ENSMUST00000115417.4
suppression of tumorigenicity 7
chr6_-_129449739 0.51 ENSMUST00000112076.9
ENSMUST00000184581.3
C-type lectin domain family 7, member a
chr14_+_32507920 0.51 ENSMUST00000039191.8
ENSMUST00000227060.2
ENSMUST00000228481.2
transmembrane protein 273
chr11_-_87249837 0.51 ENSMUST00000055438.5
protein phosphatase 1E (PP2C domain containing)
chr11_-_107228382 0.49 ENSMUST00000040380.13
phosphatidylinositol transfer protein, cytoplasmic 1
chr3_-_50398027 0.49 ENSMUST00000029297.6
ENSMUST00000194462.6
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr6_-_148732946 0.48 ENSMUST00000048418.14
importin 8
chr11_+_23256883 0.47 ENSMUST00000180046.8
ubiquitin specific peptidase 34
chr2_+_36120438 0.47 ENSMUST00000062069.6
prostaglandin-endoperoxide synthase 1
chr13_-_43634695 0.44 ENSMUST00000144326.4
RAN binding protein 9
chr11_+_23256909 0.43 ENSMUST00000137823.8
ubiquitin specific peptidase 34
chr5_-_77262968 0.43 ENSMUST00000081964.7
HOP homeobox
chr2_-_69542805 0.43 ENSMUST00000102706.4
ENSMUST00000073152.13
FAST kinase domains 1
chr19_-_46033353 0.42 ENSMUST00000026252.14
ENSMUST00000156585.9
ENSMUST00000185355.7
ENSMUST00000152946.8
LIM domain binding 1
chr3_+_32490300 0.41 ENSMUST00000029201.14
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr2_+_132689640 0.40 ENSMUST00000124836.8
ENSMUST00000154160.2
cardiolipin synthase 1
chrX_+_55500170 0.40 ENSMUST00000039374.9
ENSMUST00000101553.9
ENSMUST00000186445.7
integrator complex subunit 6 like
chr6_+_29859372 0.39 ENSMUST00000115238.10
S-adenosylhomocysteine hydrolase-like 2
chr2_+_20742115 0.39 ENSMUST00000114606.8
ENSMUST00000114608.3
enhancer trap locus 4
chr6_+_86342622 0.39 ENSMUST00000071492.9
family with sequence similarity 136, member A
chr1_-_171854818 0.39 ENSMUST00000138714.2
ENSMUST00000027837.13
ENSMUST00000111264.8
VANGL planar cell polarity 2
chr2_+_83554741 0.38 ENSMUST00000028499.11
integrin alpha V
chr7_-_108774367 0.37 ENSMUST00000207178.2
LIM domain only 1
chr11_-_74615496 0.37 ENSMUST00000021091.15
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr9_-_96513529 0.37 ENSMUST00000034984.8
RAS p21 protein activator 2
chr15_+_25774070 0.36 ENSMUST00000125667.3
myosin X
chr6_+_83142902 0.36 ENSMUST00000077407.12
ENSMUST00000113913.8
ENSMUST00000130212.8
dynactin 1
chr3_+_41519289 0.35 ENSMUST00000168086.7
jade family PHD finger 1
chr9_+_32027335 0.35 ENSMUST00000174641.8
Rho GTPase activating protein 32
chr2_-_5838489 0.34 ENSMUST00000128467.4
cell division cycle 123
chr15_-_8740218 0.34 ENSMUST00000005493.14
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_-_79539838 0.33 ENSMUST00000146824.2
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
chr9_+_118307412 0.33 ENSMUST00000035020.15
eomesodermin
chr14_-_86986541 0.33 ENSMUST00000226254.2
diaphanous related formin 3
chr10_-_129107354 0.32 ENSMUST00000204573.3
olfactory receptor 777
chr10_+_79650496 0.31 ENSMUST00000218857.2
ENSMUST00000220365.2
paralemmin
chrX_+_158086253 0.31 ENSMUST00000112491.2
ribosomal protein S6 kinase polypeptide 3
chr9_+_44309727 0.31 ENSMUST00000213268.2
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr5_+_35156454 0.31 ENSMUST00000114283.8
regulator of G-protein signaling 12
chr7_-_84339045 0.30 ENSMUST00000209165.2
zinc finger, AN1-type domain 6
chr10_+_127257077 0.30 ENSMUST00000168780.8
R3H domain containing 2
chr18_+_23885390 0.30 ENSMUST00000170802.8
ENSMUST00000155708.8
ENSMUST00000118826.9
microtubule-associated protein, RP/EB family, member 2
chr14_-_76248274 0.30 ENSMUST00000088922.5
general transcription factor IIF, polypeptide 2
chr15_-_103123711 0.30 ENSMUST00000122182.2
ENSMUST00000108813.10
ENSMUST00000127191.2
chromobox 5
chr8_-_85573489 0.30 ENSMUST00000003912.7
calreticulin
chr12_-_25147139 0.30 ENSMUST00000221761.2
inhibitor of DNA binding 2
chr2_-_86109346 0.30 ENSMUST00000217294.2
ENSMUST00000217245.2
ENSMUST00000216432.2
olfactory receptor 1051
chr16_-_95387444 0.29 ENSMUST00000233269.2
ETS transcription factor
chr18_+_56565188 0.29 ENSMUST00000070166.6
GRAM domain containing 3
chr5_-_137530214 0.29 ENSMUST00000140139.2
guanine nucleotide binding protein (G protein), beta 2
chr5_-_138169253 0.28 ENSMUST00000139983.8
minichromosome maintenance complex component 7
chr18_+_69633741 0.28 ENSMUST00000207214.2
ENSMUST00000201094.4
ENSMUST00000200703.4
ENSMUST00000202765.4
transcription factor 4
chr18_+_66591604 0.28 ENSMUST00000025399.9
ENSMUST00000237161.2
ENSMUST00000236933.2
phorbol-12-myristate-13-acetate-induced protein 1
chr14_-_64654397 0.28 ENSMUST00000210428.2
methionine sulfoxide reductase A
chr3_-_88317601 0.28 ENSMUST00000193338.6
ENSMUST00000056370.13
polyamine-modulated factor 1
chr1_+_11063678 0.27 ENSMUST00000027056.12
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_111780604 0.27 ENSMUST00000021714.9
ENSMUST00000223211.2
ENSMUST00000222843.2
ENSMUST00000221375.2
zinc finger, FYVE domain containing 21
chr2_+_170353338 0.27 ENSMUST00000136839.2
ENSMUST00000109148.8
ENSMUST00000170167.8
prefoldin 4
chr16_+_35803794 0.26 ENSMUST00000173555.8
karyopherin (importin) alpha 1
chr5_-_138169509 0.26 ENSMUST00000153867.8
minichromosome maintenance complex component 7
chr6_-_148847854 0.26 ENSMUST00000139355.8
ENSMUST00000146457.2
ENSMUST00000054080.15
SIN3-HDAC complex associated factor
chr9_+_96140781 0.26 ENSMUST00000190104.7
ENSMUST00000179416.8
ENSMUST00000189606.7
transcription factor Dp 2
chr18_+_24737009 0.25 ENSMUST00000234266.2
ENSMUST00000025120.8
elongator acetyltransferase complex subunit 2
chr2_+_4022537 0.25 ENSMUST00000177457.8
FERM domain containing 4A
chr19_+_24853039 0.25 ENSMUST00000073080.7
predicted gene 10053
chr18_-_57108405 0.25 ENSMUST00000139243.9
ENSMUST00000025488.15
RIKEN cDNA C330018D20 gene
chr3_+_67799510 0.24 ENSMUST00000063263.5
ENSMUST00000182006.4
IQ motif containing J
Iqcj and Schip1 fusion protein
chr5_-_23821523 0.24 ENSMUST00000088392.9
serine/arginine-rich protein specific kinase 2
chr9_-_96774719 0.23 ENSMUST00000154146.8
2-phosphoxylose phosphatase 1
chr5_-_138185438 0.22 ENSMUST00000110937.8
ENSMUST00000139276.2
ENSMUST00000048698.14
ENSMUST00000123415.8
TATA-box binding protein associated factor 6
chr2_+_25262327 0.22 ENSMUST00000028329.13
ENSMUST00000114293.9
ENSMUST00000100323.3
suppressor APC domain containing 2
chr11_+_94218810 0.22 ENSMUST00000107818.9
ENSMUST00000051221.13
ankyrin repeat domain 40
chr19_-_42117420 0.22 ENSMUST00000161873.2
ENSMUST00000018965.4
arginine vasopressin-induced 1
chr3_+_106020545 0.22 ENSMUST00000079132.12
ENSMUST00000139086.2
chitinase, acidic 1
chr7_+_65343156 0.21 ENSMUST00000032726.14
ENSMUST00000107495.5
ENSMUST00000143508.3
ENSMUST00000129166.3
ENSMUST00000206517.2
ENSMUST00000206837.2
ENSMUST00000206628.2
ENSMUST00000206361.2
TM2 domain containing 3
chr2_-_87504008 0.21 ENSMUST00000213835.2
olfactory receptor 1135
chr3_-_105940130 0.21 ENSMUST00000200146.2
chitinase-like 5
chr15_-_34356567 0.21 ENSMUST00000179647.2
RIKEN cDNA 9430069I07 gene
chr7_-_100232276 0.20 ENSMUST00000152876.3
ENSMUST00000150042.8
ENSMUST00000132888.9
mitochondrial ribosomal protein L48
chr18_-_38102799 0.20 ENSMUST00000166148.8
ENSMUST00000163131.8
ENSMUST00000043437.14
FCH and double SH3 domains 1
chr12_+_38830283 0.20 ENSMUST00000162563.8
ENSMUST00000161164.8
ENSMUST00000160996.8
ets variant 1
chr10_-_107321938 0.19 ENSMUST00000000445.2
myogenic factor 5
chr5_-_137529465 0.19 ENSMUST00000150063.9
guanine nucleotide binding protein (G protein), beta 2
chr15_-_66684442 0.19 ENSMUST00000100572.10
src-like adaptor
chr3_-_130523954 0.19 ENSMUST00000196202.5
ENSMUST00000133802.6
ENSMUST00000062601.14
ENSMUST00000200517.2
ribosomal protein L34
chr18_-_66155651 0.19 ENSMUST00000143990.2
lectin, mannose-binding, 1
chr14_-_64654592 0.19 ENSMUST00000210363.2
methionine sulfoxide reductase A
chr6_-_148847633 0.19 ENSMUST00000132696.8
SIN3-HDAC complex associated factor
chr11_+_98689479 0.19 ENSMUST00000037930.13
male specific lethal 1
chr4_+_122730027 0.19 ENSMUST00000030412.11
ENSMUST00000121870.8
ENSMUST00000097902.5
palmitoyl-protein thioesterase 1
chr4_+_150938376 0.19 ENSMUST00000073600.9
ERBB receptor feedback inhibitor 1
chr6_+_29853745 0.18 ENSMUST00000064872.13
ENSMUST00000152581.8
ENSMUST00000176265.8
ENSMUST00000154079.8
S-adenosylhomocysteine hydrolase-like 2
chr15_+_21111428 0.18 ENSMUST00000075132.8
cadherin 12
chr12_+_55286111 0.18 ENSMUST00000164243.2
signal recognition particle 54C
chr19_+_45433899 0.18 ENSMUST00000224478.2
beta-transducin repeat containing protein
chr4_+_99812912 0.18 ENSMUST00000102783.5
phosphoglucomutase 1
chr2_+_69727563 0.18 ENSMUST00000055758.16
ENSMUST00000112251.9
ubiquitin protein ligase E3 component n-recognin 3
chr12_+_117807224 0.17 ENSMUST00000021592.16
cell division cycle associated 7 like
chr10_+_82695013 0.17 ENSMUST00000020484.9
ENSMUST00000219962.3
thioredoxin reductase 1
chr2_+_85612365 0.17 ENSMUST00000215945.2
olfactory receptor 1015
chr14_+_32043944 0.17 ENSMUST00000022480.8
ENSMUST00000228529.2
oxoglutarate dehydrogenase-like
chr7_+_138828391 0.16 ENSMUST00000093993.5
ENSMUST00000172136.9
PWWP domain containing 2B
chr1_-_72323464 0.16 ENSMUST00000027381.13
peroxisomal trans-2-enoyl-CoA reductase
chr6_+_134617903 0.16 ENSMUST00000062755.10
BLOC-1 related complex subunit 5
chr2_+_174169351 0.16 ENSMUST00000124935.8
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chrM_+_8603 0.16 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr18_+_23548455 0.15 ENSMUST00000115832.4
dystrobrevin alpha
chr7_+_126550009 0.15 ENSMUST00000106332.3
seizure related 6 homolog like 2
chr2_+_22959452 0.15 ENSMUST00000155602.4
acyl-Coenzyme A binding domain containing 5
chr12_-_101784727 0.14 ENSMUST00000222587.2
fibulin 5
chr6_-_148732893 0.14 ENSMUST00000145960.2
importin 8
chr12_+_38830812 0.14 ENSMUST00000160856.8
ets variant 1
chr3_+_32490525 0.14 ENSMUST00000108242.2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chrX_+_157993303 0.14 ENSMUST00000112493.8
ribosomal protein S6 kinase polypeptide 3
chr12_-_40087393 0.14 ENSMUST00000146905.2
ADP-ribosylation factor-like 4A
chr13_-_103042554 0.14 ENSMUST00000171791.8
microtubule associated serine/threonine kinase family member 4
chr5_-_123127346 0.14 ENSMUST00000118027.8
lysine (K)-specific demethylase 2B
chr7_-_4909515 0.13 ENSMUST00000210663.2
predicted gene, 36210
chr10_+_127919142 0.13 ENSMUST00000026459.6
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr18_+_34891941 0.13 ENSMUST00000049281.12
family with sequence similarity 53, member C
chr16_+_35861554 0.13 ENSMUST00000042203.10
WD repeat domain 5B
chr4_+_140428777 0.13 ENSMUST00000138808.8
ENSMUST00000038893.6
regulator of chromosome condensation 2
chr2_+_71219561 0.13 ENSMUST00000028408.3
histone aminotransferase 1
chr14_+_55132030 0.12 ENSMUST00000141446.8
ENSMUST00000139985.8
poly(A) binding protein, nuclear 1
chr17_-_31417834 0.12 ENSMUST00000236793.2
transmembrane protease, serine 3
chr13_+_94219934 0.12 ENSMUST00000156071.2
lipoma HMGIC fusion partner-like 2
chr8_-_68427217 0.12 ENSMUST00000098696.10
ENSMUST00000038959.16
ENSMUST00000093469.11
pleckstrin and Sec7 domain containing 3
chr9_+_96140750 0.12 ENSMUST00000186609.7
transcription factor Dp 2
chr5_-_138185686 0.12 ENSMUST00000110936.8
TATA-box binding protein associated factor 6
chr19_+_26727111 0.12 ENSMUST00000175842.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_96552895 0.12 ENSMUST00000119365.8
ENSMUST00000029744.6
integrin, alpha 10
chrM_+_7758 0.12 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
chr15_+_41694317 0.12 ENSMUST00000166917.3
ENSMUST00000230127.2
ENSMUST00000230131.2
oxidation resistance 1
chr8_+_22996233 0.12 ENSMUST00000210854.2
solute carrier family 20, member 2
chr9_-_75448979 0.12 ENSMUST00000214171.2
tropomodulin 3
chr10_+_26648473 0.12 ENSMUST00000039557.9
Rho GTPase activating protein 18
chr2_+_89642395 0.12 ENSMUST00000214508.2
olfactory receptor 1255
chr7_+_51528788 0.12 ENSMUST00000107591.9
growth arrest specific 2
chr15_+_34495441 0.12 ENSMUST00000052290.14
ENSMUST00000079028.6
processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
chr5_+_14075281 0.11 ENSMUST00000073957.8
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr4_-_4138817 0.11 ENSMUST00000133567.2
preproenkephalin
chr5_-_92496730 0.11 ENSMUST00000038816.13
ENSMUST00000118006.3
chemokine (C-X-C motif) ligand 10
chrM_+_9459 0.11 ENSMUST00000082411.1
mitochondrially encoded NADH dehydrogenase 3
chr7_+_107411470 0.11 ENSMUST00000208563.3
ENSMUST00000214253.2
olfactory receptor 467
chr3_-_49711706 0.11 ENSMUST00000191794.2
protocadherin 18
chr3_-_49711765 0.11 ENSMUST00000035931.13
protocadherin 18
chr4_-_14621805 0.11 ENSMUST00000042221.14
solute carrier family 26, member 7
chr1_-_72323407 0.10 ENSMUST00000097698.5
peroxisomal trans-2-enoyl-CoA reductase
chr9_-_71070506 0.10 ENSMUST00000074465.9
aquaporin 9
chr14_-_52341472 0.10 ENSMUST00000111610.12
ENSMUST00000164655.2
heterogeneous nuclear ribonucleoprotein C
chr13_+_51562675 0.10 ENSMUST00000087978.5
sphingosine-1-phosphate receptor 3
chr2_-_84255602 0.10 ENSMUST00000074262.9
calcitonin receptor-like
chr10_+_39488930 0.10 ENSMUST00000019987.7
TRAF3 interacting protein 2
chr7_+_18962252 0.10 ENSMUST00000063976.9
optic atrophy 3
chr2_+_59442378 0.10 ENSMUST00000112568.8
ENSMUST00000037526.11
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr18_+_36414122 0.10 ENSMUST00000051301.6
purine rich element binding protein A
chr4_-_82768958 0.09 ENSMUST00000139401.2
zinc finger, DHHC domain containing 21
chr2_+_22959223 0.09 ENSMUST00000114523.10
acyl-Coenzyme A binding domain containing 5
chrX_+_149372903 0.09 ENSMUST00000080884.11
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_-_98790275 0.09 ENSMUST00000037968.10
UV radiation resistance associated gene
chr13_+_21363602 0.09 ENSMUST00000222544.2
tripartite motif-containing 27
chr10_+_126911134 0.09 ENSMUST00000239120.2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_76836545 0.09 ENSMUST00000125145.8
bleomycin hydrolase
chr6_-_50631418 0.09 ENSMUST00000031853.8
neuropeptide VF precursor
chr14_+_55797443 0.09 ENSMUST00000117236.8
DDB1 and CUL4 associated factor 11
chr2_+_87686206 0.09 ENSMUST00000217376.2
olfactory receptor 1151
chr12_-_87435091 0.09 ENSMUST00000021424.5
serine palmitoyltransferase, long chain base subunit 2
chr11_-_99265721 0.09 ENSMUST00000006963.3
keratin 28
chr5_-_123126550 0.09 ENSMUST00000086200.11
ENSMUST00000156474.8
lysine (K)-specific demethylase 2B
chrM_+_7779 0.08 ENSMUST00000082408.1
mitochondrially encoded ATP synthase 6
chr2_-_34803988 0.08 ENSMUST00000028232.7
ENSMUST00000202907.2
PHD finger protein 19
chr11_+_11634967 0.08 ENSMUST00000141436.8
ENSMUST00000126058.8
IKAROS family zinc finger 1
chr1_-_138103021 0.08 ENSMUST00000182755.8
ENSMUST00000193650.2
ENSMUST00000182283.8
protein tyrosine phosphatase, receptor type, C
chr9_+_89081407 0.08 ENSMUST00000138109.2
predicted gene 29094

Network of associatons between targets according to the STRING database.

First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 0.6 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.2 0.9 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 0.6 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.2 1.3 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.2 1.4 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.7 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.4 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 0.4 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.1 0.7 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.3 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.1 0.3 GO:0002501 MHC protein complex assembly(GO:0002396) peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 0.3 GO:0001966 thigmotaxis(GO:0001966)
0.1 0.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.4 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 0.3 GO:1903173 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.1 0.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 1.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.6 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.2 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.0 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.4 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0043418 homocysteine catabolic process(GO:0043418)
0.0 0.3 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.0 0.4 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.3 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:2000473 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.0 0.2 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.2 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.0 0.3 GO:0035166 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) post-embryonic hemopoiesis(GO:0035166)
0.0 0.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.0 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.0 0.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
0.0 0.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.1 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.1 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.3 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.1 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:1904502 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0 0.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.1 GO:0072592 positive regulation of integrin biosynthetic process(GO:0045726) oxygen metabolic process(GO:0072592)
0.0 0.1 GO:0015676 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.0 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.1 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 0.0 GO:0006649 phospholipid transfer to membrane(GO:0006649)
0.0 0.1 GO:0046549 retinal cone cell development(GO:0046549)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 0.6 GO:1904511 cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511)
0.2 0.6 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.1 1.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.3 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 1.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.0 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.0 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0030430 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.7 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.3 GO:0015152 glucose-6-phosphate transmembrane transporter activity(GO:0015152)
0.1 1.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.9 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.3 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.2 GO:0033797 selenate reductase activity(GO:0033797)
0.1 0.3 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0001571 non-tyrosine kinase fibroblast growth factor receptor activity(GO:0001571)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.0 GO:0071820 N-box binding(GO:0071820)
0.0 0.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.0 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.0 0.0 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.0 GO:0008988 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0070095 6-phosphofructo-2-kinase activity(GO:0003873) fructose-6-phosphate binding(GO:0070095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.5 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID ATR PATHWAY ATR signaling pathway
0.0 0.8 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.0 0.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains