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avrg: GFI1 WT vs 36n/n vs KD
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Results for Xbp1_Creb3l1
Z-value: 1.75
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Transcription factors associated with Xbp1_Creb3l1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb3l1 | mm39_v1_chr2_-_91854844_91854847 | 0.35 | 5.6e-01 | Click! |
| Xbp1 | mm39_v1_chr11_+_5470652_5470659 | 0.23 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_72935382 Show fit | 2.13 |
ENSMUST00000144337.2
|
thymosin, beta 10 |
|
| chr3_+_123061094 Show fit | 1.35 |
ENSMUST00000047923.12
ENSMUST00000200333.2 |
Sec24 related gene family, member D (S. cerevisiae) |
|
| chr15_+_31224555 Show fit | 1.17 |
ENSMUST00000186109.2
|
death-associated protein |
|
| chr6_-_72935468 Show fit | 1.06 |
ENSMUST00000114050.8
|
thymosin, beta 10 |
|
| chr6_-_72935171 Show fit | 0.96 |
ENSMUST00000114049.2
|
thymosin, beta 10 |
|
| chr15_+_31224616 Show fit | 0.95 |
ENSMUST00000186547.7
|
death-associated protein |
|
| chr14_+_26359191 Show fit | 0.91 |
ENSMUST00000022429.9
|
ADP-ribosylation factor 4 |
|
| chr14_+_26359390 Show fit | 0.88 |
ENSMUST00000112318.10
|
ADP-ribosylation factor 4 |
|
| chr3_-_131196213 Show fit | 0.83 |
ENSMUST00000197057.2
|
sphingomyelin synthase 2 |
|
| chr2_+_80145805 Show fit | 0.82 |
ENSMUST00000028392.8
|
DnaJ heat shock protein family (Hsp40) member C10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Xbp1_Creb3l1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.2 | 1.8 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.1 | 1.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 0.9 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 0.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 0.8 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 0.7 | GO:2000845 | positive regulation of testosterone secretion(GO:2000845) |
| 0.0 | 0.7 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.2 | 0.6 | GO:0060435 | bronchiole development(GO:0060435) intestinal epithelial cell maturation(GO:0060574) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.5 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.1 | 1.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 1.1 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.0 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.3 | 0.9 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 0.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 0.4 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 2.9 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 1.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.8 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.8 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.7 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 0.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 0.6 | GO:0004020 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.1 | 0.6 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.8 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.2 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.1 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |