ISMARA results: Yy1

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Yy1_Yy2

Z-value: 3.61

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Transcription factors associated with Yy1_Yy2

Gene Symbol	Gene ID	Gene Info
Yy1 Ensembl NCBI MGI UniProt	ENSMUSG00000021264.13	YY1 transcription factor
Yy2 Ensembl NCBI MGI UniProt	ENSMUSG00000091736.4	Yy2 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Yy1	mm39_v1_chr12_+_108758871_108758914	0.22	7.2e-01	Click!
Yy2	mm39_v1_chrX_-_156351979_156351987	-0.17	7.9e-01	Click!

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_138159333 Show fit	1.85	ENSMUST00000019638.15 ENSMUST00000110951.8	Cops6 Ensembl NCBI MGI UniProt Show fit	COP9 signalosome subunit 6
chr13_-_97897139 Show fit	1.81	ENSMUST00000074072.5	Rps18-ps6 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S18, pseudogene 6
chr7_+_28524627 Show fit	1.80	ENSMUST00000066264.13	Ech1 Ensembl NCBI MGI UniProt Show fit	enoyl coenzyme A hydratase 1, peroxisomal
chr13_+_55862437 Show fit	1.61	ENSMUST00000021959.11	Txndc15 Ensembl NCBI MGI UniProt Show fit	thioredoxin domain containing 15
chr8_+_85583611 Show fit	1.58	ENSMUST00000003906.13 ENSMUST00000109754.2	Farsa Ensembl NCBI MGI UniProt Show fit	phenylalanyl-tRNA synthetase, alpha subunit
chr15_-_79967543 Show fit	1.48	ENSMUST00000081650.15	Rpl3 Ensembl NCBI MGI UniProt Show fit	ribosomal protein L3
chr10_-_128384971 Show fit	1.46	ENSMUST00000176906.2	Rpl41 Ensembl NCBI MGI UniProt Show fit	ribosomal protein L41
chr9_-_50515089 Show fit	1.30	ENSMUST00000000175.6	Sdhd Ensembl NCBI MGI UniProt Show fit	succinate dehydrogenase complex, subunit D, integral membrane protein
chrX_+_93768175 Show fit	1.29	ENSMUST00000101388.4	Zxdb Ensembl NCBI MGI UniProt Show fit	zinc finger, X-linked, duplicated B
chr18_+_84106188 Show fit	1.25	ENSMUST00000060223.4	Zadh2 Ensembl NCBI MGI UniProt Show fit	zinc binding alcohol dehydrogenase, domain containing 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	GO:0042254	ribosome biogenesis(GO:0042254)
0.1	7.0	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2	6.6	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.1	5.0	GO:0032543	mitochondrial translation(GO:0032543)
0.2	4.9	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.1	4.5	GO:0045454	cell redox homeostasis(GO:0045454)
0.2	4.0	GO:0000338	protein deneddylation(GO:0000338)
0.0	3.9	GO:0006487	protein N-linked glycosylation(GO:0006487)
0.1	3.7	GO:0002181	cytoplasmic translation(GO:0002181)
0.2	3.2	GO:0001731	formation of translation preinitiation complex(GO:0001731)

Showing 1 to 10 of 822 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	24.6	GO:0005739	mitochondrion(GO:0005739)
0.2	12.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	11.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	9.2	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2	8.9	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	7.5	GO:0015935	small ribosomal subunit(GO:0015935)
0.2	7.4	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	5.0	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	4.6	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	4.4	GO:0043209	myelin sheath(GO:0043209)

Showing 1 to 10 of 314 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	30.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	6.0	GO:0003954	NADH dehydrogenase activity(GO:0003954)
0.0	5.9	GO:0004175	endopeptidase activity(GO:0004175)
0.1	5.8	GO:0003743	translation initiation factor activity(GO:0003743)
0.3	4.0	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	3.4	GO:0008565	protein transporter activity(GO:0008565)
0.0	3.4	GO:0008233	peptidase activity(GO:0008233)
0.0	3.3	GO:0051082	unfolded protein binding(GO:0051082)
0.2	3.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.1	3.1	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Showing 1 to 10 of 500 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	4.7	PID AURORA B PATHWAY	Aurora B signaling
0.0	3.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	2.2	PID ATR PATHWAY	ATR signaling pathway
0.0	2.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	2.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	2.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	1.9	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	1.8	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	23.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	13.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	10.0	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	6.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	6.2	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1	5.2	REACTOME TRANSLATION	Genes involved in Translation
0.1	5.1	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2	4.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	4.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	4.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 136 entries

Results for Yy1_Yy2

Z-value: 3.61

Motif logo

Transcription factors associated with Yy1_Yy2

Activity-expression correlation:

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: