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avrg: GFI1 WT vs 36n/n vs KD

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Results for Zfp128

Z-value: 0.94

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Transcription factors associated with Zfp128

Gene Symbol Gene ID Gene Info
Zfp128
ENSMUSG00000060397.7 zinc finger protein 128

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp128mm39_v1_chr7_+_12615091_12615132-0.513.8e-01Click!

Activity profile of Zfp128 motif

Sorted Z-values of Zfp128 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_27290969 0.53 ENSMUST00000108344.9
Akt2
thymoma viral proto-oncogene 2
chr5_-_138169253 0.52 ENSMUST00000139983.8
Mcm7
minichromosome maintenance complex component 7
chr5_-_138169509 0.47 ENSMUST00000153867.8
Mcm7
minichromosome maintenance complex component 7
chr11_-_116164928 0.45 ENSMUST00000106425.4
Srp68
signal recognition particle 68
chr14_-_106134253 0.44 ENSMUST00000022709.6
Spry2
sprouty RTK signaling antagonist 2
chr5_-_147662798 0.40 ENSMUST00000110529.6
ENSMUST00000031653.12
Flt1
FMS-like tyrosine kinase 1
chr5_-_121329385 0.36 ENSMUST00000054547.9
ENSMUST00000100770.9
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
chr17_+_34062059 0.36 ENSMUST00000002379.15
Cd320
CD320 antigen
chr9_+_21323120 0.33 ENSMUST00000002902.8
Qtrt1
queuine tRNA-ribosyltransferase catalytic subunit 1
chr11_-_116165024 0.31 ENSMUST00000021133.16
Srp68
signal recognition particle 68
chr9_+_3335135 0.28 ENSMUST00000212294.2
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr13_+_67080864 0.24 ENSMUST00000021990.4
Ptdss1
phosphatidylserine synthase 1
chr13_-_58532990 0.24 ENSMUST00000022032.7
2210016F16Rik
RIKEN cDNA 2210016F16 gene
chr15_-_96540760 0.24 ENSMUST00000088452.11
Slc38a1
solute carrier family 38, member 1
chr8_+_84442133 0.23 ENSMUST00000109810.2
Ddx39a
DEAD box helicase 39a
chr18_+_56565188 0.22 ENSMUST00000070166.6
Gramd3
GRAM domain containing 3
chr11_-_69553390 0.22 ENSMUST00000129224.8
ENSMUST00000155200.8
Mpdu1
mannose-P-dolichol utilization defect 1
chrX_-_133483849 0.21 ENSMUST00000113213.2
ENSMUST00000033617.13
Btk
Bruton agammaglobulinemia tyrosine kinase
chr5_-_138169476 0.20 ENSMUST00000147920.2
Mcm7
minichromosome maintenance complex component 7
chr8_-_127672590 0.18 ENSMUST00000179857.3
ENSMUST00000212771.2
Tomm20
translocase of outer mitochondrial membrane 20
chr8_+_84441806 0.18 ENSMUST00000019576.15
Ddx39a
DEAD box helicase 39a
chr8_+_84441854 0.17 ENSMUST00000172396.8
Ddx39a
DEAD box helicase 39a
chr6_-_54969843 0.16 ENSMUST00000203208.2
Ggct
gamma-glutamyl cyclotransferase
chr13_-_67080968 0.14 ENSMUST00000172597.8
ENSMUST00000173773.2
Mterf3
mitochondrial transcription termination factor 3
chr9_-_35087348 0.14 ENSMUST00000119847.2
ENSMUST00000034539.12
Dcps
decapping enzyme, scavenger
chr7_-_45175570 0.13 ENSMUST00000167273.2
ENSMUST00000042105.11
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
chr15_+_76211597 0.13 ENSMUST00000059045.8
Exosc4
exosome component 4
chr9_+_3335469 0.13 ENSMUST00000053407.13
ENSMUST00000211933.2
ENSMUST00000212666.2
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr9_-_59260713 0.11 ENSMUST00000026265.8
Bbs4
Bardet-Biedl syndrome 4 (human)
chr4_+_126450728 0.11 ENSMUST00000048391.15
Clspn
claspin
chr5_+_137759934 0.10 ENSMUST00000110983.3
ENSMUST00000031738.5
Tsc22d4
TSC22 domain family, member 4
chr6_-_54969928 0.10 ENSMUST00000131475.2
Ggct
gamma-glutamyl cyclotransferase
chr7_+_45084300 0.09 ENSMUST00000211150.2
Gys1
glycogen synthase 1, muscle
chr7_-_45084012 0.07 ENSMUST00000107771.12
ENSMUST00000211666.2
Ruvbl2
RuvB-like protein 2
chr1_-_4855894 0.07 ENSMUST00000130201.8
ENSMUST00000156816.7
ENSMUST00000146665.3
Mrpl15
mitochondrial ribosomal protein L15
chr13_-_59917569 0.07 ENSMUST00000057115.7
Isca1
iron-sulfur cluster assembly 1
chr3_+_37474422 0.06 ENSMUST00000029277.13
ENSMUST00000198968.2
Spata5
spermatogenesis associated 5
chr9_+_3335507 0.05 ENSMUST00000212154.2
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr12_-_75596441 0.05 ENSMUST00000218716.2
Ppp2r5e
protein phosphatase 2, regulatory subunit B', epsilon
chr11_-_69553451 0.04 ENSMUST00000018905.12
Mpdu1
mannose-P-dolichol utilization defect 1
chr6_-_128339458 0.04 ENSMUST00000155573.3
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr5_+_34493633 0.04 ENSMUST00000182709.8
ENSMUST00000030992.13
Rnf4
ring finger protein 4
chr7_-_44578834 0.03 ENSMUST00000107857.11
ENSMUST00000167930.8
ENSMUST00000085399.13
ENSMUST00000166972.9
Ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr7_+_45084257 0.03 ENSMUST00000003964.17
Gys1
glycogen synthase 1, muscle
chr3_-_79475078 0.03 ENSMUST00000133154.7
Fnip2
folliculin interacting protein 2
chr11_-_11920540 0.02 ENSMUST00000109653.8
Grb10
growth factor receptor bound protein 10
chr3_+_135053762 0.00 ENSMUST00000159658.8
ENSMUST00000078568.12
Slc9b1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr16_+_8500694 0.00 ENSMUST00000202157.2
Gm5767
predicted gene 5767
chr3_+_144824644 0.00 ENSMUST00000199124.5
Odf2l
outer dense fiber of sperm tails 2-like
chr17_-_26463092 0.00 ENSMUST00000118487.8
ENSMUST00000234262.2
Fam234a
family with sequence similarity 234, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp128

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2000850 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1 1.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.5 GO:0071486 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.4 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 0.4 GO:0031296 B cell costimulation(GO:0031296)
0.1 0.2 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.1 0.4 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0036245 cellular response to menadione(GO:0036245)
0.0 0.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.2 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.0 0.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.2 GO:0006868 glutamine transport(GO:0006868)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 0.0 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.2 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 0.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 1.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling