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avrg: GFI1 WT vs 36n/n vs KD

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Results for Zfp282

Z-value: 0.99

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Transcription factors associated with Zfp282

Gene Symbol Gene ID Gene Info
Zfp282
ENSMUSG00000025821.10 zinc finger protein 282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp282mm39_v1_chr6_+_47854138_478541380.237.0e-01Click!

Activity profile of Zfp282 motif

Sorted Z-values of Zfp282 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_35255729 0.74 ENSMUST00000040962.6
Nudt19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr4_+_41760454 0.64 ENSMUST00000108040.8
Il11ra1
interleukin 11 receptor, alpha chain 1
chr12_+_87490666 0.58 ENSMUST00000161023.8
ENSMUST00000160488.8
ENSMUST00000077462.8
ENSMUST00000160880.2
Slirp
SRA stem-loop interacting RNA binding protein
chr16_+_10884156 0.54 ENSMUST00000089011.6
Snn
stannin
chr2_-_91274967 0.53 ENSMUST00000064652.14
ENSMUST00000102594.11
ENSMUST00000094835.9
1110051M20Rik
RIKEN cDNA 1110051M20 gene
chr1_-_125362321 0.52 ENSMUST00000191544.7
Actr3
ARP3 actin-related protein 3
chr4_+_102843540 0.51 ENSMUST00000030248.12
ENSMUST00000125417.9
ENSMUST00000169211.3
Dynlt5
dynein light chain Tctex-type 5
chr11_-_68864666 0.50 ENSMUST00000038644.5
Rangrf
RAN guanine nucleotide release factor
chr1_+_134383247 0.50 ENSMUST00000112232.8
ENSMUST00000027725.11
ENSMUST00000116528.2
Klhl12
kelch-like 12
chr12_+_71021395 0.43 ENSMUST00000160027.8
ENSMUST00000160864.8
Psma3
proteasome subunit alpha 3
chr7_+_142558783 0.43 ENSMUST00000009396.13
Tspan32
tetraspanin 32
chr3_-_88858465 0.43 ENSMUST00000173135.8
Dap3
death associated protein 3
chr8_-_23727639 0.42 ENSMUST00000033950.7
Gins4
GINS complex subunit 4 (Sld5 homolog)
chr7_-_143294051 0.40 ENSMUST00000119499.8
Osbpl5
oxysterol binding protein-like 5
chr11_-_120687195 0.39 ENSMUST00000143139.8
ENSMUST00000129955.2
ENSMUST00000026151.11
ENSMUST00000167023.8
ENSMUST00000106133.8
ENSMUST00000106135.8
Dus1l
dihydrouridine synthase 1-like (S. cerevisiae)
chr19_-_21418215 0.38 ENSMUST00000237823.2
Gda
guanine deaminase
chr7_+_142558837 0.38 ENSMUST00000207211.2
Tspan32
tetraspanin 32
chr1_+_36800874 0.37 ENSMUST00000027291.7
Zap70
zeta-chain (TCR) associated protein kinase
chr14_+_119175328 0.33 ENSMUST00000022734.9
Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
chr3_-_88858402 0.33 ENSMUST00000173021.8
Dap3
death associated protein 3
chr1_+_151220222 0.32 ENSMUST00000023918.13
ENSMUST00000111887.10
ENSMUST00000097543.8
Ivns1abp
influenza virus NS1A binding protein
chr2_+_35512023 0.31 ENSMUST00000091010.12
Dab2ip
disabled 2 interacting protein
chr9_-_114610879 0.30 ENSMUST00000084867.9
ENSMUST00000216760.2
ENSMUST00000035009.16
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr10_+_93289264 0.29 ENSMUST00000016033.9
Lta4h
leukotriene A4 hydrolase
chr7_+_101732323 0.27 ENSMUST00000124189.3
Trpc2
transient receptor potential cation channel, subfamily C, member 2
chr9_-_105008972 0.27 ENSMUST00000186925.2
Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr2_+_35512172 0.26 ENSMUST00000112992.9
Dab2ip
disabled 2 interacting protein
chr1_+_52884172 0.25 ENSMUST00000159352.8
ENSMUST00000044478.7
Hibch
3-hydroxyisobutyryl-Coenzyme A hydrolase
chr13_-_9815173 0.25 ENSMUST00000062658.15
ENSMUST00000222358.2
Zmynd11
zinc finger, MYND domain containing 11
chr4_-_40239778 0.24 ENSMUST00000037907.13
Ddx58
DEAD/H box helicase 58
chr13_-_9815350 0.23 ENSMUST00000110636.9
ENSMUST00000152725.8
Zmynd11
zinc finger, MYND domain containing 11
chr19_-_6835538 0.22 ENSMUST00000113440.2
Ccdc88b
coiled-coil domain containing 88B
chr7_-_90106375 0.22 ENSMUST00000032844.7
Tmem126a
transmembrane protein 126A
chr5_-_65548723 0.19 ENSMUST00000120094.5
ENSMUST00000127874.6
ENSMUST00000057885.13
Rpl9
ribosomal protein L9
chr10_+_20024203 0.19 ENSMUST00000020173.16
Map7
microtubule-associated protein 7
chr9_-_105009023 0.19 ENSMUST00000035179.9
Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr13_-_9815276 0.18 ENSMUST00000130151.8
Zmynd11
zinc finger, MYND domain containing 11
chr8_+_3726503 0.17 ENSMUST00000207787.2
Trappc5
trafficking protein particle complex 5
chr3_+_154302311 0.17 ENSMUST00000192462.6
ENSMUST00000029850.15
Cryz
crystallin, zeta
chr12_-_87490580 0.17 ENSMUST00000162961.8
ENSMUST00000185301.2
Alkbh1
alkB homolog 1, histone H2A dioxygenase
chr7_+_16472335 0.17 ENSMUST00000086112.8
ENSMUST00000205607.2
Ap2s1
adaptor-related protein complex 2, sigma 1 subunit
chr5_+_65548840 0.17 ENSMUST00000122026.6
ENSMUST00000031101.10
ENSMUST00000200374.2
Lias
lipoic acid synthetase
chr3_-_88857707 0.17 ENSMUST00000090938.11
Dap3
death associated protein 3
chr5_-_122270014 0.16 ENSMUST00000128101.8
ENSMUST00000132701.2
Ccdc63
coiled-coil domain containing 63
chr16_+_87251852 0.16 ENSMUST00000119504.8
ENSMUST00000131356.8
Usp16
ubiquitin specific peptidase 16
chrY_-_90850446 0.16 ENSMUST00000179623.2
Gm21748
predicted gene, 21748
chr12_+_72583114 0.15 ENSMUST00000044352.8
Pcnx4
pecanex homolog 4
chr12_+_111504450 0.15 ENSMUST00000166123.9
ENSMUST00000222441.2
Eif5
eukaryotic translation initiation factor 5
chr11_-_102298748 0.14 ENSMUST00000124755.2
Slc25a39
solute carrier family 25, member 39
chr3_+_93349637 0.14 ENSMUST00000064257.6
Tchh
trichohyalin
chr7_-_105289515 0.14 ENSMUST00000133519.8
ENSMUST00000209550.2
ENSMUST00000210911.2
ENSMUST00000084782.10
ENSMUST00000131446.8
Arfip2
ADP-ribosylation factor interacting protein 2
chr9_-_83028523 0.14 ENSMUST00000187193.7
ENSMUST00000185315.7
Hmgn3
high mobility group nucleosomal binding domain 3
chr2_+_24276545 0.13 ENSMUST00000127242.2
Psd4
pleckstrin and Sec7 domain containing 4
chr4_+_14864076 0.13 ENSMUST00000029875.4
Pip4p2
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr13_-_53531391 0.13 ENSMUST00000021920.8
Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr7_+_105289729 0.13 ENSMUST00000210350.2
ENSMUST00000151193.2
ENSMUST00000209588.2
ENSMUST00000106780.2
ENSMUST00000106784.2
ENSMUST00000106785.8
ENSMUST00000106786.8
ENSMUST00000211054.2
Timm10b
Gm45799
translocase of inner mitochondrial membrane 10B
predicted gene 45799
chr5_-_129907878 0.11 ENSMUST00000026617.13
Phkg1
phosphorylase kinase gamma 1
chr7_-_45175570 0.10 ENSMUST00000167273.2
ENSMUST00000042105.11
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
chr17_-_33904345 0.10 ENSMUST00000234474.2
ENSMUST00000139302.8
ENSMUST00000114385.9
Hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr9_+_108782664 0.10 ENSMUST00000026740.6
Col7a1
collagen, type VII, alpha 1
chr17_-_50401305 0.10 ENSMUST00000113195.8
Rftn1
raftlin lipid raft linker 1
chr7_-_10229249 0.10 ENSMUST00000032551.8
Zik1
zinc finger protein interacting with K protein 1
chr11_-_102120917 0.10 ENSMUST00000008999.12
Hdac5
histone deacetylase 5
chr19_-_18609118 0.10 ENSMUST00000025631.7
ENSMUST00000236615.2
Ostf1
osteoclast stimulating factor 1
chr11_-_102120953 0.09 ENSMUST00000107150.8
ENSMUST00000156337.2
ENSMUST00000107151.9
ENSMUST00000107152.9
Hdac5
histone deacetylase 5
chr6_-_39787813 0.09 ENSMUST00000114797.2
ENSMUST00000031978.9
Mrps33
mitochondrial ribosomal protein S33
chr9_-_85631361 0.09 ENSMUST00000039213.15
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr12_+_111504640 0.08 ENSMUST00000222375.2
ENSMUST00000222388.2
Eif5
eukaryotic translation initiation factor 5
chr17_-_33904386 0.08 ENSMUST00000087582.13
Hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr19_-_5538370 0.07 ENSMUST00000124334.8
Mus81
MUS81 structure-specific endonuclease subunit
chr10_+_20024724 0.07 ENSMUST00000116259.5
ENSMUST00000214231.2
Map7
microtubule-associated protein 7
chr7_+_107264518 0.06 ENSMUST00000239294.2
Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_+_26298502 0.05 ENSMUST00000033979.6
Star
steroidogenic acute regulatory protein
chr11_+_9068098 0.05 ENSMUST00000020677.8
ENSMUST00000101525.9
Upp1
uridine phosphorylase 1
chr2_+_3771709 0.05 ENSMUST00000177037.2
Fam107b
family with sequence similarity 107, member B
chr11_-_109188892 0.05 ENSMUST00000106706.8
Rgs9
regulator of G-protein signaling 9
chr4_-_148244028 0.04 ENSMUST00000167160.8
ENSMUST00000151246.8
Fbxo44
F-box protein 44
chr13_+_23343482 0.04 ENSMUST00000226845.2
ENSMUST00000228666.2
ENSMUST00000227388.2
Vmn1r219
vomeronasal 1 receptor 219
chr14_+_31058589 0.04 ENSMUST00000022451.14
Capn7
calpain 7
chr15_-_103337982 0.04 ENSMUST00000146736.8
Gtsf1
gametocyte specific factor 1
chr17_+_46991926 0.04 ENSMUST00000233491.2
Mea1
male enhanced antigen 1
chr10_-_19727165 0.03 ENSMUST00000059805.6
Slc35d3
solute carrier family 35, member D3
chr13_-_22289994 0.03 ENSMUST00000227357.2
ENSMUST00000228428.2
Vmn1r189
vomeronasal 1 receptor 189
chr11_+_9068507 0.03 ENSMUST00000164791.8
ENSMUST00000130522.8
Upp1
uridine phosphorylase 1
chr9_+_38738911 0.03 ENSMUST00000051238.7
ENSMUST00000219798.2
Olfr923
olfactory receptor 923
chr7_+_105289655 0.02 ENSMUST00000058333.10
Timm10b
translocase of inner mitochondrial membrane 10B
chr7_-_29772226 0.02 ENSMUST00000183115.8
ENSMUST00000182919.8
ENSMUST00000183190.2
ENSMUST00000080834.15
Zfp82
zinc finger protein 82
chr6_+_68518603 0.02 ENSMUST00000168090.3
ENSMUST00000103326.3
Igkv1-99
immunoglobulin kappa variable 1-99
chrX_+_134894573 0.02 ENSMUST00000058119.9
Arxes2
adipocyte-related X-chromosome expressed sequence 2
chr7_-_47849036 0.02 ENSMUST00000094388.3
Mrgprb4
MAS-related GPR, member B4
chr18_-_35855383 0.02 ENSMUST00000133064.8
Ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr11_+_9068134 0.02 ENSMUST00000170444.8
Upp1
uridine phosphorylase 1
chr2_-_125466985 0.02 ENSMUST00000089776.3
Cep152
centrosomal protein 152
chr5_-_87638728 0.02 ENSMUST00000147854.6
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr14_+_66207163 0.02 ENSMUST00000153460.8
Clu
clusterin
chr3_-_108306267 0.02 ENSMUST00000147251.2
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr6_-_128503666 0.01 ENSMUST00000143664.2
ENSMUST00000112132.8
Pzp
PZP, alpha-2-macroglobulin like
chr17_+_46991350 0.01 ENSMUST00000232732.2
Mea1
male enhanced antigen 1
chr2_-_88818544 0.01 ENSMUST00000099804.2
Olfr1214
olfactory receptor 1214
chr19_+_13140364 0.01 ENSMUST00000207113.3
Olfr1461
olfactory receptor 1461
chr17_+_38378064 0.01 ENSMUST00000087129.3
Olfr130
olfactory receptor 130
chr9_+_45341589 0.01 ENSMUST00000239471.2
ENSMUST00000034592.11
ENSMUST00000239429.2
Dscaml1
DS cell adhesion molecule like 1
chr18_-_78222349 0.01 ENSMUST00000237290.2
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr16_+_7011580 0.01 ENSMUST00000231194.2
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_87522267 0.01 ENSMUST00000165109.2
ENSMUST00000070898.6
Neu2
neuraminidase 2
chr7_-_106291021 0.01 ENSMUST00000216118.3
Olfr694
olfactory receptor 694
chr4_-_148244489 0.01 ENSMUST00000057907.10
Fbxo44
F-box protein 44
chr8_-_93774820 0.00 ENSMUST00000095211.5
Ces1a
carboxylesterase 1A
chr16_-_85599994 0.00 ENSMUST00000023610.15
Adamts1
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
chr19_+_5385672 0.00 ENSMUST00000043380.5
Catsper1
cation channel, sperm associated 1
chrY_-_2170393 0.00 ENSMUST00000115891.2
Zfy2
zinc finger protein 2, Y-linked
chr4_-_88562696 0.00 ENSMUST00000105149.3
Ifna13
interferon alpha 13
chr3_-_92577621 0.00 ENSMUST00000029530.6
Lce1a2
late cornified envelope 1A2
chr6_-_83504756 0.00 ENSMUST00000152029.2
Actg2
actin, gamma 2, smooth muscle, enteric
chr2_-_160754212 0.00 ENSMUST00000109454.8
ENSMUST00000057169.5
Emilin3
elastin microfibril interfacer 3
chrX_+_104543374 0.00 ENSMUST00000041758.5
Cypt2
cysteine-rich perinuclear theca 2
chr7_+_26456567 0.00 ENSMUST00000077855.8
Cyp2b19
cytochrome P450, family 2, subfamily b, polypeptide 19
chrX_+_102458066 0.00 ENSMUST00000033691.5
Tsx
testis specific X-linked gene
chr11_+_49170977 0.00 ENSMUST00000078932.2
Olfr1393
olfactory receptor 1393
chr14_+_41000762 0.00 ENSMUST00000172412.2
Gm2832
predicted gene 2832
chr14_+_75479727 0.00 ENSMUST00000022576.10
Cpb2
carboxypeptidase B2 (plasma)

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp282

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 0.6 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1 0.5 GO:1904171 negative regulation of bleb assembly(GO:1904171)
0.1 0.4 GO:0046098 guanine metabolic process(GO:0046098)
0.1 0.5 GO:0046707 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.1 0.5 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.3 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.1 0.8 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 0.3 GO:0036493 positive regulation of translational initiation in response to stress(GO:0032058) positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.1 0.4 GO:0043366 beta selection(GO:0043366)
0.1 0.2 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.1 0.5 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.5 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101) RNA repair(GO:0042245)
0.0 0.2 GO:0070537 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.1 GO:0046108 uridine catabolic process(GO:0006218) uridine metabolic process(GO:0046108)
0.0 0.4 GO:0046697 decidualization(GO:0046697)
0.0 0.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.3 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 0.7 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0021554 optic nerve development(GO:0021554)
0.0 0.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.0 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.1 0.6 GO:1990032 parallel fiber(GO:1990032)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.0 0.3 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.2 0.5 GO:0035870 dITP diphosphatase activity(GO:0035870)
0.1 0.4 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0043734 DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 0.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0048256 flap endonuclease activity(GO:0048256)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10