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avrg: GFI1 WT vs 36n/n vs KD

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Results for Zkscan3

Z-value: 0.69

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Transcription factors associated with Zkscan3

Gene Symbol Gene ID Gene Info
Zkscan3
ENSMUSG00000021327.20 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zkscan3mm39_v1_chr13_-_21586858_215869250.801.1e-01Click!

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_75313350 0.74 ENSMUST00000125982.2
ENSMUST00000137103.8
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr11_-_75313412 0.67 ENSMUST00000138661.8
ENSMUST00000000769.14
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr1_-_65162267 0.43 ENSMUST00000050047.4
ENSMUST00000148020.8
D630023F18Rik
RIKEN cDNA D630023F18 gene
chr5_-_100720063 0.35 ENSMUST00000031264.12
Plac8
placenta-specific 8
chr19_+_6952580 0.34 ENSMUST00000237084.2
ENSMUST00000236218.2
ENSMUST00000237235.2
Ppp1r14b
protein phosphatase 1, regulatory inhibitor subunit 14B
chr13_-_100922910 0.31 ENSMUST00000174038.2
ENSMUST00000091295.14
ENSMUST00000072119.15
Ccnb1
cyclin B1
chr11_-_88742285 0.30 ENSMUST00000107903.8
Akap1
A kinase (PRKA) anchor protein 1
chr11_-_102255999 0.30 ENSMUST00000006749.10
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chrX_-_17437801 0.29 ENSMUST00000177213.8
Fundc1
FUN14 domain containing 1
chr2_+_103900164 0.28 ENSMUST00000111131.9
ENSMUST00000111132.8
ENSMUST00000129749.8
Cd59b
CD59b antigen
chr7_-_141936355 0.25 ENSMUST00000133843.8
Gm49369
predicted gene, 49369
chr13_-_19579898 0.24 ENSMUST00000197565.3
ENSMUST00000221380.2
ENSMUST00000200323.3
ENSMUST00000199924.2
ENSMUST00000222869.2
Stard3nl
STARD3 N-terminal like
chr6_+_127430668 0.23 ENSMUST00000039680.7
Parp11
poly (ADP-ribose) polymerase family, member 11
chr12_+_33004178 0.23 ENSMUST00000020885.13
Sypl
synaptophysin-like protein
chr2_+_31560725 0.22 ENSMUST00000038474.14
ENSMUST00000137156.2
Exosc2
exosome component 2
chr13_+_73615316 0.22 ENSMUST00000022099.15
Lpcat1
lysophosphatidylcholine acyltransferase 1
chr8_+_125624615 0.20 ENSMUST00000034467.7
Sprtn
SprT-like N-terminal domain
chr5_+_24791719 0.20 ENSMUST00000088295.9
ENSMUST00000121863.5
Chpf2
chondroitin polymerizing factor 2
chr4_+_156110621 0.19 ENSMUST00000103173.10
ENSMUST00000040274.13
ENSMUST00000122001.3
Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr5_-_88823472 0.18 ENSMUST00000113234.8
ENSMUST00000153565.8
Grsf1
G-rich RNA sequence binding factor 1
chr1_-_185061525 0.17 ENSMUST00000027921.11
ENSMUST00000110975.8
ENSMUST00000110974.4
Iars2
isoleucine-tRNA synthetase 2, mitochondrial
chrX_-_17438520 0.17 ENSMUST00000026016.13
Fundc1
FUN14 domain containing 1
chr5_+_24791796 0.17 ENSMUST00000197318.2
Chpf2
chondroitin polymerizing factor 2
chr17_-_35984409 0.16 ENSMUST00000162266.8
ENSMUST00000160734.8
ENSMUST00000159852.2
ENSMUST00000160039.8
Gtf2h4
general transcription factor II H, polypeptide 4
chr18_-_34784746 0.16 ENSMUST00000025228.12
ENSMUST00000133181.2
Cdc23
CDC23 cell division cycle 23
chr8_+_107620251 0.16 ENSMUST00000212272.2
ENSMUST00000047629.7
Utp4
UTP4 small subunit processome component
chr2_-_103609703 0.16 ENSMUST00000143188.2
Caprin1
cell cycle associated protein 1
chr1_+_180770064 0.15 ENSMUST00000159436.8
Tmem63a
transmembrane protein 63a
chr7_-_19297001 0.15 ENSMUST00000058444.10
Ppp1r37
protein phosphatase 1, regulatory subunit 37
chr1_+_58834621 0.15 ENSMUST00000191201.7
Casp8
caspase 8
chr2_-_30084124 0.13 ENSMUST00000113659.8
ENSMUST00000113660.2
Kyat1
kynurenine aminotransferase 1
chr7_+_101545547 0.12 ENSMUST00000035395.14
ENSMUST00000106973.8
ENSMUST00000144207.9
Anapc15
anaphase promoting complex C subunit 15
chr13_-_19579961 0.12 ENSMUST00000039694.13
Stard3nl
STARD3 N-terminal like
chr5_-_88823049 0.12 ENSMUST00000133532.8
ENSMUST00000150438.2
Grsf1
G-rich RNA sequence binding factor 1
chr8_+_34222266 0.11 ENSMUST00000190675.2
ENSMUST00000171010.8
Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr3_-_129518723 0.10 ENSMUST00000199615.5
ENSMUST00000197079.5
Egf
epidermal growth factor
chr13_-_38842967 0.09 ENSMUST00000001757.9
Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr1_-_40829801 0.09 ENSMUST00000039672.6
Mfsd9
major facilitator superfamily domain containing 9
chr6_+_125048230 0.08 ENSMUST00000140346.9
ENSMUST00000171989.3
Lpar5
lysophosphatidic acid receptor 5
chr4_-_62438122 0.08 ENSMUST00000107444.8
ENSMUST00000030090.4
Alad
aminolevulinate, delta-, dehydratase
chr6_-_113696809 0.08 ENSMUST00000203770.3
ENSMUST00000064993.8
Ghrl
ghrelin
chr6_+_125529911 0.07 ENSMUST00000112254.8
ENSMUST00000112253.6
Vwf
Von Willebrand factor
chr8_-_107620210 0.07 ENSMUST00000177068.8
ENSMUST00000176515.2
ENSMUST00000169312.2
Chtf8
Derpc
CTF8, chromosome transmission fidelity factor 8
DERPC proline and glycine rich nuclear protein
chr17_-_34736326 0.07 ENSMUST00000075483.5
Btnl6
butyrophilin-like 6
chr6_-_43643093 0.07 ENSMUST00000114644.8
ENSMUST00000067888.14
Tpk1
thiamine pyrophosphokinase
chr11_+_87295860 0.07 ENSMUST00000060835.12
Tex14
testis expressed gene 14
chr13_-_64514830 0.07 ENSMUST00000222971.2
Ctsl
cathepsin L
chr15_-_4008913 0.07 ENSMUST00000022791.9
Fbxo4
F-box protein 4
chr5_+_118114826 0.07 ENSMUST00000035579.10
Fbxo21
F-box protein 21
chr16_-_16176729 0.06 ENSMUST00000230980.2
ENSMUST00000096229.11
ENSMUST00000230038.2
ENSMUST00000023477.15
Dnm1l
dynamin 1-like
chr7_+_19144950 0.05 ENSMUST00000208710.2
ENSMUST00000003643.3
Ckm
creatine kinase, muscle
chr13_-_65260716 0.05 ENSMUST00000054730.10
ENSMUST00000155487.8
Mfsd14b
major facilitator superfamily domain containing 14B
chr2_+_121001683 0.05 ENSMUST00000186659.7
ENSMUST00000039541.12
ENSMUST00000110657.2
Tubgcp4
tubulin, gamma complex associated protein 4
chr17_-_34694911 0.05 ENSMUST00000065841.5
Btnl4
butyrophilin-like 4
chr4_+_101944740 0.05 ENSMUST00000106911.8
Pde4b
phosphodiesterase 4B, cAMP specific
chr17_+_46421908 0.05 ENSMUST00000024763.10
ENSMUST00000123646.2
Mrps18a
mitochondrial ribosomal protein S18A
chr5_+_120787253 0.05 ENSMUST00000156722.2
Rasal1
RAS protein activator like 1 (GAP1 like)
chr1_+_160806194 0.04 ENSMUST00000064725.11
ENSMUST00000191936.2
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_116327853 0.04 ENSMUST00000140884.8
ENSMUST00000129170.8
Marchf8
membrane associated ring-CH-type finger 8
chr12_+_112555656 0.04 ENSMUST00000220786.2
Inf2
inverted formin, FH2 and WH2 domain containing
chr11_-_102109748 0.03 ENSMUST00000131254.2
Hdac5
histone deacetylase 5
chr2_+_155617251 0.03 ENSMUST00000029141.6
Mmp24
matrix metallopeptidase 24
chr7_-_97827461 0.03 ENSMUST00000040971.14
Capn5
calpain 5
chr10_+_80465481 0.02 ENSMUST00000085435.7
Csnk1g2
casein kinase 1, gamma 2
chr9_+_114517812 0.02 ENSMUST00000047404.7
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr14_-_32407203 0.02 ENSMUST00000096038.4
3425401B19Rik
RIKEN cDNA 3425401B19 gene
chr1_+_180770016 0.02 ENSMUST00000027800.15
Tmem63a
transmembrane protein 63a
chr18_+_67933169 0.02 ENSMUST00000025425.7
Cep192
centrosomal protein 192
chr1_-_128256048 0.02 ENSMUST00000073490.7
Lct
lactase
chr17_-_35984625 0.02 ENSMUST00000001565.15
Gtf2h4
general transcription factor II H, polypeptide 4
chr11_-_99700718 0.01 ENSMUST00000050106.5
Krtap4-13
keratin associated protein 4-13
chr13_+_42862957 0.01 ENSMUST00000066928.12
ENSMUST00000148891.8
Phactr1
phosphatase and actin regulator 1
chr11_-_99689758 0.01 ENSMUST00000105057.2
Gm11569
predicted gene 11569
chrX_+_162923474 0.01 ENSMUST00000073973.11
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr10_+_81164552 0.01 ENSMUST00000105325.4
ENSMUST00000220312.2
Tbxa2r
thromboxane A2 receptor
chr11_-_99695272 0.01 ENSMUST00000105056.2
Gm11554
predicted gene 11554
chr3_+_87458556 0.01 ENSMUST00000238853.2
Etv3l
ets variant 3-like
chr2_+_32536594 0.01 ENSMUST00000113272.8
ENSMUST00000009705.14
ENSMUST00000167841.8
Eng
endoglin
chr6_+_149041289 0.01 ENSMUST00000126406.8
Etfbkmt
electron transfer flavoprotein beta subunit lysine methyltransferase
chr5_+_53424471 0.01 ENSMUST00000147148.5
Smim20
small integral membrane protein 20
chr1_-_173161069 0.00 ENSMUST00000038227.6
Ackr1
atypical chemokine receptor 1 (Duffy blood group)
chr10_+_75404482 0.00 ENSMUST00000134503.8
ENSMUST00000125770.8
ENSMUST00000128886.8
ENSMUST00000151212.8
Ggt1
gamma-glutamyltransferase 1
chr14_-_52648384 0.00 ENSMUST00000079459.4
Olfr1510
olfactory receptor 1510
chr4_+_15957923 0.00 ENSMUST00000029879.15
ENSMUST00000149069.2
Nbn
nibrin
chr19_+_6326755 0.00 ENSMUST00000025684.4
Ehd1
EH-domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.3 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.2 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.2 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.1 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.0 0.2 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149) regulation of peroxisome organization(GO:1900063)
0.0 0.1 GO:1904000 positive regulation of eating behavior(GO:1904000) regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768) negative regulation of energy homeostasis(GO:2000506)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0045062 extrathymic T cell selection(GO:0045062)
0.0 0.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0043203 axon hillock(GO:0043203)
0.1 0.3 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.2 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.2 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.0 0.1 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.1 GO:0047945 L-phenylalanine:pyruvate aminotransferase activity(GO:0047312) glutamine-phenylpyruvate transaminase activity(GO:0047316) L-glutamine:pyruvate aminotransferase activity(GO:0047945)
0.0 0.1 GO:0031768 ghrelin receptor binding(GO:0031768)
0.0 0.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0030984 kininogen binding(GO:0030984)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis