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avrg: GFI1 WT vs 36n/n vs KD

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Results for Zscan4c

Z-value: 0.70

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Transcription factors associated with Zscan4c

Gene Symbol Gene ID Gene Info
Zscan4c
ENSMUSG00000054272.7 zinc finger and SCAN domain containing 4C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zscan4cmm39_v1_chr7_+_10739672_10739672-0.731.6e-01Click!

Activity profile of Zscan4c motif

Sorted Z-values of Zscan4c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_61431271 0.62 ENSMUST00000020287.8
Npffr1
neuropeptide FF receptor 1
chr4_-_87724533 0.53 ENSMUST00000126353.8
ENSMUST00000149357.8
Mllt3
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr18_-_42395207 0.48 ENSMUST00000097590.5
Lars
leucyl-tRNA synthetase
chr4_-_87724512 0.44 ENSMUST00000148059.2
Mllt3
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr7_+_46490899 0.38 ENSMUST00000147535.8
Ldha
lactate dehydrogenase A
chr10_-_37014859 0.38 ENSMUST00000092584.6
Marcks
myristoylated alanine rich protein kinase C substrate
chr11_-_101676076 0.37 ENSMUST00000164750.8
ENSMUST00000107176.8
ENSMUST00000017868.7
Etv4
ets variant 4
chr4_-_136620376 0.34 ENSMUST00000046332.6
C1qc
complement component 1, q subcomponent, C chain
chr19_-_6117815 0.33 ENSMUST00000162575.8
ENSMUST00000159084.8
ENSMUST00000161718.8
ENSMUST00000162810.8
ENSMUST00000025713.12
ENSMUST00000113543.9
ENSMUST00000160417.8
ENSMUST00000161528.2
Tm7sf2
transmembrane 7 superfamily member 2
chr15_-_77037972 0.32 ENSMUST00000111581.4
ENSMUST00000166610.8
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr15_+_44482944 0.30 ENSMUST00000022964.9
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr7_-_132723918 0.26 ENSMUST00000172341.8
Ctbp2
C-terminal binding protein 2
chr18_-_42395131 0.25 ENSMUST00000236102.2
Lars
leucyl-tRNA synthetase
chr7_-_108774367 0.24 ENSMUST00000207178.2
Lmo1
LIM domain only 1
chr13_-_9815173 0.23 ENSMUST00000062658.15
ENSMUST00000222358.2
Zmynd11
zinc finger, MYND domain containing 11
chr13_-_9815350 0.22 ENSMUST00000110636.9
ENSMUST00000152725.8
Zmynd11
zinc finger, MYND domain containing 11
chr12_+_52550775 0.22 ENSMUST00000219443.2
Arhgap5
Rho GTPase activating protein 5
chr2_+_30254239 0.20 ENSMUST00000077977.14
ENSMUST00000140075.9
ENSMUST00000142801.8
ENSMUST00000100214.10
Miga2
mitoguardin 2
chr13_-_9814979 0.19 ENSMUST00000110634.8
Zmynd11
zinc finger, MYND domain containing 11
chr3_-_107667499 0.19 ENSMUST00000153114.2
ENSMUST00000118593.8
ENSMUST00000120243.8
Csf1
colony stimulating factor 1 (macrophage)
chr11_-_70128712 0.17 ENSMUST00000108577.8
ENSMUST00000108579.8
ENSMUST00000021181.13
ENSMUST00000108578.9
ENSMUST00000102569.10
0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr15_+_44482545 0.17 ENSMUST00000227691.2
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr13_-_9815276 0.17 ENSMUST00000130151.8
Zmynd11
zinc finger, MYND domain containing 11
chr2_-_157988303 0.17 ENSMUST00000103122.10
Tgm2
transglutaminase 2, C polypeptide
chr11_-_70128462 0.17 ENSMUST00000100950.10
0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr4_-_129534403 0.15 ENSMUST00000084264.12
Txlna
taxilin alpha
chr8_-_117459730 0.15 ENSMUST00000109102.4
Cdyl2
chromodomain protein, Y chromosome-like 2
chr10_+_18345706 0.15 ENSMUST00000162891.8
ENSMUST00000100054.4
Nhsl1
NHS-like 1
chr15_-_77037756 0.15 ENSMUST00000227314.2
ENSMUST00000227930.2
ENSMUST00000227533.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_51184730 0.15 ENSMUST00000195432.2
ENSMUST00000091144.11
ENSMUST00000156983.3
Elf2
E74-like factor 2
chr13_-_9814901 0.15 ENSMUST00000223421.2
ENSMUST00000128658.8
Zmynd11
zinc finger, MYND domain containing 11
chr15_+_44482667 0.14 ENSMUST00000228648.2
ENSMUST00000226165.2
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr16_-_78373537 0.14 ENSMUST00000232052.2
ENSMUST00000114219.8
ENSMUST00000114218.2
D16Ertd472e
DNA segment, Chr 16, ERATO Doi 472, expressed
chr12_+_52551092 0.14 ENSMUST00000217820.2
Arhgap5
Rho GTPase activating protein 5
chr16_-_78373510 0.14 ENSMUST00000231973.2
ENSMUST00000232528.2
ENSMUST00000114220.9
D16Ertd472e
DNA segment, Chr 16, ERATO Doi 472, expressed
chr5_+_115034997 0.13 ENSMUST00000031542.13
ENSMUST00000146072.8
ENSMUST00000150361.2
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr15_-_77037926 0.13 ENSMUST00000228087.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_96309600 0.12 ENSMUST00000129646.8
ENSMUST00000113005.9
ENSMUST00000154500.2
ENSMUST00000141383.8
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr3_-_51184895 0.12 ENSMUST00000108051.8
ENSMUST00000108053.9
Elf2
E74-like factor 2
chr9_+_21279802 0.12 ENSMUST00000214474.2
Ilf3
interleukin enhancer binding factor 3
chr13_-_76205115 0.11 ENSMUST00000056130.8
Gpr150
G protein-coupled receptor 150
chr5_-_145138639 0.10 ENSMUST00000162220.2
ENSMUST00000031632.9
ENSMUST00000198959.2
Zkscan14
zinc finger with KRAB and SCAN domains 14
chr16_-_78373570 0.10 ENSMUST00000231272.2
D16Ertd472e
DNA segment, Chr 16, ERATO Doi 472, expressed
chr1_+_87983099 0.10 ENSMUST00000138182.8
ENSMUST00000113142.10
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr9_+_111011388 0.10 ENSMUST00000217117.2
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr1_+_87983189 0.09 ENSMUST00000173325.2
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr11_-_109364046 0.09 ENSMUST00000070872.13
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr6_+_48570817 0.08 ENSMUST00000154010.8
ENSMUST00000009420.15
ENSMUST00000163452.7
ENSMUST00000118229.2
ENSMUST00000135151.3
Repin1
replication initiator 1
chr19_-_46033353 0.08 ENSMUST00000026252.14
ENSMUST00000156585.9
ENSMUST00000185355.7
ENSMUST00000152946.8
Ldb1
LIM domain binding 1
chr9_+_21848282 0.08 ENSMUST00000046371.13
Plppr2
phospholipid phosphatase related 2
chr11_-_70128587 0.08 ENSMUST00000108576.10
0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr9_-_50639367 0.08 ENSMUST00000117646.8
Dixdc1
DIX domain containing 1
chr6_-_145811274 0.08 ENSMUST00000032386.11
Bhlhe41
basic helix-loop-helix family, member e41
chr11_-_70128678 0.07 ENSMUST00000108575.9
0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr3_-_135313982 0.06 ENSMUST00000132668.8
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr19_+_53298906 0.06 ENSMUST00000003870.15
Mxi1
MAX interactor 1, dimerization protein
chr19_-_28657477 0.05 ENSMUST00000162022.8
ENSMUST00000112612.9
Glis3
GLIS family zinc finger 3
chr11_-_113642135 0.05 ENSMUST00000106616.2
Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr11_-_113641980 0.05 ENSMUST00000153453.2
Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr13_+_55517545 0.05 ENSMUST00000063771.14
Rgs14
regulator of G-protein signaling 14
chr9_+_111011327 0.05 ENSMUST00000216430.2
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr4_+_114914880 0.05 ENSMUST00000161601.8
Tal1
T cell acute lymphocytic leukemia 1
chr9_+_37466989 0.04 ENSMUST00000213126.2
Siae
sialic acid acetylesterase
chr10_-_81360059 0.04 ENSMUST00000043709.8
Gna15
guanine nucleotide binding protein, alpha 15
chr15_-_98705791 0.03 ENSMUST00000075444.8
Ddn
dendrin
chr2_+_85804239 0.03 ENSMUST00000217244.2
Olfr1029
olfactory receptor 1029
chr18_+_64473091 0.03 ENSMUST00000175965.10
Onecut2
one cut domain, family member 2
chrX_+_47608122 0.02 ENSMUST00000033430.3
Rab33a
RAB33A, member RAS oncogene family
chr11_+_49442576 0.02 ENSMUST00000167248.3
Olfr1381
olfactory receptor 1381
chr7_-_45519853 0.02 ENSMUST00000211713.2
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr3_-_63758672 0.02 ENSMUST00000162269.9
ENSMUST00000159676.9
ENSMUST00000175947.8
Plch1
phospholipase C, eta 1
chr11_-_113642635 0.02 ENSMUST00000053536.5
Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr6_-_145811028 0.02 ENSMUST00000111703.2
Bhlhe41
basic helix-loop-helix family, member e41
chr10_+_87694117 0.02 ENSMUST00000122386.8
Igf1
insulin-like growth factor 1
chr11_+_49426014 0.01 ENSMUST00000074543.2
Olfr1382
olfactory receptor 1382
chr3_+_133942244 0.01 ENSMUST00000181904.3
Cxxc4
CXXC finger 4
chr9_+_43978369 0.01 ENSMUST00000177054.8
Usp2
ubiquitin specific peptidase 2
chr15_-_37458768 0.01 ENSMUST00000116445.9
Ncald
neurocalcin delta
chr19_-_21449916 0.01 ENSMUST00000087600.10
Gda
guanine deaminase
chr2_-_35994819 0.01 ENSMUST00000148852.4
Lhx6
LIM homeobox protein 6
chr5_-_129030111 0.01 ENSMUST00000196085.5
Rimbp2
RIMS binding protein 2
chr5_-_44956932 0.01 ENSMUST00000199261.2
ENSMUST00000199534.5
Ldb2
LIM domain binding 2
chr14_+_122712809 0.01 ENSMUST00000075888.6
Zic2
zinc finger protein of the cerebellum 2
chr6_+_91661074 0.01 ENSMUST00000205480.2
ENSMUST00000206545.2
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr9_+_26645024 0.01 ENSMUST00000160899.8
ENSMUST00000161431.3
ENSMUST00000159799.8
B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr6_+_52290415 0.01 ENSMUST00000031787.8
ENSMUST00000129243.3
Evx1
even-skipped homeobox 1
chr13_-_114595122 0.01 ENSMUST00000231252.2
Fst
follistatin
chr3_+_125197722 0.01 ENSMUST00000173932.8
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr10_-_114638202 0.00 ENSMUST00000239411.2
Trhde
TRH-degrading enzyme
chr5_-_44956981 0.00 ENSMUST00000070748.10
Ldb2
LIM domain binding 2
chr10_+_102348076 0.00 ENSMUST00000219445.2
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr16_-_9812410 0.00 ENSMUST00000115835.8
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr5_-_44957016 0.00 ENSMUST00000199256.5
Ldb2
LIM domain binding 2
chr11_-_37126709 0.00 ENSMUST00000102801.8
Tenm2
teneurin transmembrane protein 2
chr14_+_117163215 0.00 ENSMUST00000078849.12
Gpc6
glypican 6
chrX_-_160942713 0.00 ENSMUST00000087085.10
Nhs
NHS actin remodeling regulator
chr10_+_84938452 0.00 ENSMUST00000095383.6
Tmem263
transmembrane protein 263
chr16_-_38533597 0.00 ENSMUST00000023487.5
Arhgap31
Rho GTPase activating protein 31
chr9_+_26645141 0.00 ENSMUST00000115269.9
B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr3_+_13538266 0.00 ENSMUST00000211860.2
Ralyl
RALY RNA binding protein-like
chr7_+_50248918 0.00 ENSMUST00000119710.3
4933405O20Rik
RIKEN cDNA 4933405O20 gene
chr13_+_58955675 0.00 ENSMUST00000224402.2
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr11_-_52036355 0.00 ENSMUST00000078264.2
Olfr1373
olfactory receptor 1373
chr9_-_31824758 0.00 ENSMUST00000116615.5
Barx2
BarH-like homeobox 2
chr19_-_43879031 0.00 ENSMUST00000212048.2
Dnmbp
dynamin binding protein
chr2_-_115895528 0.00 ENSMUST00000028639.13
ENSMUST00000102538.11
Meis2
Meis homeobox 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Zscan4c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.1 0.2 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 0.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 1.0 GO:2000096 segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.6 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.4 GO:0019659 glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 0.4 GO:0060762 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.0 0.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 1.0 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:1904632 negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
0.0 0.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.5 GO:0016589 NURF complex(GO:0016589)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.0 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.1 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0071820 N-box binding(GO:0071820)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis