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avrg: 12D miR HR13_24
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Results for Ascl2
Z-value: 3.10
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Transcription factors associated with Ascl2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ascl2 | mm10_v2_chr7_-_142969238_142969264 | -0.53 | 9.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_128206346 Show fit | 8.52 |
ENSMUST00000033049.7
|
cytochrome c oxidase subunit VIa polypeptide 2 |
|
| chr15_-_71727815 Show fit | 4.09 |
ENSMUST00000022953.8
|
family with sequence similarity 135, member B |
|
| chr12_-_17176888 Show fit | 3.97 |
ENSMUST00000170580.1
|
potassium voltage-gated channel, subfamily F, member 1 |
|
| chr11_-_120648104 Show fit | 3.75 |
ENSMUST00000026134.2
|
myeloid-associated differentiation marker-like 2 |
|
| chr11_+_69965396 Show fit | 3.62 |
ENSMUST00000018713.6
|
claudin 7 |
|
| chr6_+_107529717 Show fit | 3.55 |
ENSMUST00000049285.8
|
leucine rich repeat protein 1, neuronal |
|
| chr4_-_138367966 Show fit | 3.47 |
ENSMUST00000030535.3
|
cytidine deaminase |
|
| chr4_-_141846359 Show fit | 3.22 |
ENSMUST00000037059.10
|
chymotrypsin C (caldecrin) |
|
| chr7_-_143074037 Show fit | 3.22 |
ENSMUST00000136602.1
|
transient receptor potential cation channel, subfamily M, member 5 |
|
| chr10_+_127866457 Show fit | 3.17 |
ENSMUST00000092058.3
|
cDNA sequence BC089597 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ascl2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.8 | 5.7 | GO:1904222 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.2 | 4.3 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.1 | 4.3 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 0.0 | 3.8 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.2 | 3.6 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 1.2 | 3.5 | GO:0009972 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.0 | 3.5 | GO:0006874 | cellular calcium ion homeostasis(GO:0006874) |
| 0.1 | 3.2 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.2 | 3.0 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 4.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.3 | 4.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 3.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 2.1 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 1.8 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.2 | 1.8 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 8.5 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.4 | 5.7 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.3 | 4.4 | GO:0019203 | carbohydrate phosphatase activity(GO:0019203) |
| 0.2 | 4.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 4.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 4.1 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.6 | 3.5 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.2 | 3.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 3.2 | GO:0005272 | sodium channel activity(GO:0005272) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 4.0 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.2 | 2.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.8 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 2.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.7 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 2.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 5.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 4.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 3.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 2.6 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 2.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |