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avrg: 12D miR HR13_24
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Results for Atf6
Z-value: 3.54
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Transcription factors associated with Atf6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf6 | mm10_v2_chr1_-_170867761_170867784 | -0.01 | 9.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_91139591 Show fit | 3.90 |
ENSMUST00000031325.4
|
amphiregulin |
|
| chrX_-_20291728 Show fit | 3.81 |
ENSMUST00000115393.2
|
solute carrier family 9 (sodium/hydrogen exchanger), member 7 |
|
| chr13_-_92131494 Show fit | 3.64 |
ENSMUST00000099326.3
ENSMUST00000146492.1 |
RAS protein-specific guanine nucleotide-releasing factor 2 |
|
| chr5_+_137288273 Show fit | 3.31 |
ENSMUST00000024099.4
ENSMUST00000085934.3 |
acetylcholinesterase |
|
| chr11_+_69991061 Show fit | 2.98 |
ENSMUST00000018711.8
|
gamma-aminobutyric acid receptor associated protein |
|
| chr7_-_128237984 Show fit | 2.86 |
ENSMUST00000078816.3
|
RIKEN cDNA 9130023H24 gene |
|
| chr19_+_16956110 Show fit | 2.71 |
ENSMUST00000087689.4
|
prune homolog 2 (Drosophila) |
|
| chr10_-_81291227 Show fit | 2.69 |
ENSMUST00000045744.6
|
tight junction protein 3 |
|
| chr5_+_35056813 Show fit | 2.66 |
ENSMUST00000101298.2
ENSMUST00000114270.1 ENSMUST00000133381.1 |
docking protein 7 |
|
| chr5_-_65492984 Show fit | 2.47 |
ENSMUST00000139122.1
|
small integral membrane protein 14 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Atf6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.1 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.7 | 5.2 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.4 | 5.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 4.9 | GO:0061098 | positive regulation of protein tyrosine kinase activity(GO:0061098) |
| 0.5 | 4.8 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.1 | 4.6 | GO:0051591 | response to cAMP(GO:0051591) |
| 0.2 | 4.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 1.0 | 3.9 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 0.1 | 3.8 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.3 | 3.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.3 | 7.3 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.3 | 6.8 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.2 | 6.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 5.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 5.4 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 5.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.3 | 4.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.3 | 3.8 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.7 | 3.5 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.5 | 6.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 5.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.2 | 5.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 5.3 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 1.3 | 5.2 | GO:0004104 | cholinesterase activity(GO:0004104) |
| 0.1 | 4.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 3.8 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 3.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 3.1 | GO:0008565 | protein transporter activity(GO:0008565) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 5.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 3.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 2.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 2.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 1.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 6.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 5.0 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 4.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 4.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 3.8 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.3 | 3.5 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 3.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 2.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |