ISMARA results: Chd1

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avrg: 12D miR HR13_24

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Results for Chd1_Pml

Z-value: 4.04

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Transcription factors associated with Chd1_Pml

Gene Symbol	Gene ID	Gene Info
Chd1 Ensembl NCBI MGI UniProt	ENSMUSG00000023852.7	chromodomain helicase DNA binding protein 1
Pml Ensembl NCBI MGI UniProt	ENSMUSG00000036986.10	promyelocytic leukemia

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Chd1	mm10_v2_chr17_+_15704963_15704994	-0.76	6.6e-03	Click!
Pml	mm10_v2_chr9_-_58249660_58249672	-0.38	2.4e-01	Click!

Activity profile of Chd1_Pml motif

Sorted Z-values of Chd1_Pml motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_87625214 Show fit	11.07	ENSMUST00000068088.6	Fam19a5 Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 19, member A5
chr12_-_84698769 Show fit	8.82	ENSMUST00000095550.2	Syndig1l Ensembl NCBI MGI UniProt Show fit	synapse differentiation inducing 1 like
chr11_-_119086221 Show fit	6.54	ENSMUST00000026665.7	Cbx4 Ensembl NCBI MGI UniProt Show fit	chromobox 4
chr9_+_114978507 Show fit	6.31	ENSMUST00000183104.1	Osbpl10 Ensembl NCBI MGI UniProt Show fit	oxysterol binding protein-like 10
chr13_-_71963713 Show fit	5.82	ENSMUST00000077337.8	Irx1 Ensembl NCBI MGI UniProt Show fit	Iroquois related homeobox 1 (Drosophila)
chr11_+_120530688 Show fit	5.78	ENSMUST00000026119.7	Gcgr Ensembl NCBI MGI UniProt Show fit	glucagon receptor
chr4_+_137277489 Show fit	5.65	ENSMUST00000045747.4	Wnt4 Ensembl NCBI MGI UniProt Show fit	wingless-related MMTV integration site 4
chr5_+_138995038 Show fit	4.99	ENSMUST00000100518.2	6330403L08Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 6330403L08 gene
chr6_+_107529717 Show fit	4.75	ENSMUST00000049285.8	Lrrn1 Ensembl NCBI MGI UniProt Show fit	leucine rich repeat protein 1, neuronal
chr17_+_24752980 Show fit	4.70	ENSMUST00000044922.6	Hs3st6 Ensembl NCBI MGI UniProt Show fit	heparan sulfate (glucosamine) 3-O-sulfotransferase 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Chd1_Pml

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	12.4	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
2.7	11.0	GO:0072272	proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.3	10.2	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
1.4	10.0	GO:0071896	protein localization to adherens junction(GO:0071896)
0.8	9.9	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.3	9.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
1.4	8.2	GO:0032439	endosome localization(GO:0032439)
0.3	8.0	GO:0018345	protein palmitoylation(GO:0018345)
0.5	7.1	GO:1990118	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
1.0	6.8	GO:0019695	choline metabolic process(GO:0019695)

Showing 1 to 10 of 998 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	57.0	GO:0005794	Golgi apparatus(GO:0005794)
0.0	26.9	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	14.9	GO:0048786	presynaptic active zone(GO:0048786)
0.3	12.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.6	9.4	GO:0001533	cornified envelope(GO:0001533)
0.5	9.0	GO:0035102	PRC1 complex(GO:0035102)
0.6	8.6	GO:0045179	apical cortex(GO:0045179)
0.1	8.2	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	7.5	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	7.1	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)

Showing 1 to 10 of 294 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	30.8	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	21.2	GO:0005080	protein kinase C binding(GO:0005080)
0.2	13.2	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.7	12.8	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.1	9.1	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	8.2	GO:0008013	beta-catenin binding(GO:0008013)
0.2	8.1	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.3	7.9	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	7.8	GO:0019003	GDP binding(GO:0019003)
1.4	7.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)

Showing 1 to 10 of 557 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.6	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.4	14.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	13.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	10.3	PID BMP PATHWAY	BMP receptor signaling
0.2	10.1	PID REELIN PATHWAY	Reelin signaling pathway
0.1	8.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	7.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.3	6.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	5.8	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	5.5	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	12.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	11.1	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.2	10.4	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.5	9.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.5	8.8	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	8.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	8.4	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.3	8.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	8.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA

Showing 1 to 10 of 171 entries

Results for Chd1_Pml

Z-value: 4.04

Motif logo

Transcription factors associated with Chd1_Pml

Activity-expression correlation:

Activity profile of Chd1_Pml motif

Sorted Z-values of Chd1_Pml motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Chd1_Pml

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: