Project
avrg: 12D miR HR13_24
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Results for Creb3
Z-value: 2.98
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Transcription factors associated with Creb3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb3 | mm10_v2_chr4_+_43562672_43562947 | -0.32 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_91139591 Show fit | 3.45 |
ENSMUST00000031325.4
|
amphiregulin |
|
| chrX_+_73787002 Show fit | 3.34 |
ENSMUST00000166518.1
|
signal sequence receptor, delta |
|
| chrX_+_73787062 Show fit | 3.28 |
ENSMUST00000002090.2
|
signal sequence receptor, delta |
|
| chrX_-_20291728 Show fit | 3.20 |
ENSMUST00000115393.2
|
solute carrier family 9 (sodium/hydrogen exchanger), member 7 |
|
| chr5_+_113735782 Show fit | 3.15 |
ENSMUST00000065698.5
|
FIC domain containing |
|
| chr18_+_65800543 Show fit | 2.69 |
ENSMUST00000025394.6
ENSMUST00000153193.1 |
SEC11 homolog C (S. cerevisiae) |
|
| chr13_-_37994111 Show fit | 2.52 |
ENSMUST00000021864.6
|
signal sequence receptor, alpha |
|
| chr8_-_106136792 Show fit | 2.30 |
ENSMUST00000146940.1
|
epithelial splicing regulatory protein 2 |
|
| chrX_-_20291776 Show fit | 2.23 |
ENSMUST00000072451.4
|
solute carrier family 9 (sodium/hydrogen exchanger), member 7 |
|
| chr6_-_71144338 Show fit | 2.18 |
ENSMUST00000074241.7
ENSMUST00000160918.1 |
threonine synthase-like 2 (bacterial) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Creb3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.4 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 4.5 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.9 | 3.5 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 0.3 | 3.4 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.3 | 3.3 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.3 | 3.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 3.0 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 2.9 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.3 | 2.7 | GO:1903298 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) |
| 0.2 | 2.7 | GO:0006465 | signal peptide processing(GO:0006465) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 6.6 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.3 | 5.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 5.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 2.7 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 2.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.2 | 2.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 2.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 2.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.4 | 2.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 2.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.4 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 4.2 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.1 | 3.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 3.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 3.2 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 3.2 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.1 | 2.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 2.7 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.6 | 2.5 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.2 | 2.5 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 3.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 1.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 0.8 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 5.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 4.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 2.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 1.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 1.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 1.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.5 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |