Project
avrg: 12D miR HR13_24
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Results for E2f1
Z-value: 6.42
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Transcription factors associated with E2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f1 | mm10_v2_chr2_-_154569845_154569892 | 0.91 | 1.1e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_89294608 Show fit | 9.67 |
ENSMUST00000107131.1
|
cyclin-dependent kinase inhibitor 2A |
|
| chr4_+_126556935 Show fit | 8.33 |
ENSMUST00000048391.8
|
claspin |
|
| chr1_-_20820213 Show fit | 7.89 |
ENSMUST00000053266.9
|
minichromosome maintenance deficient 3 (S. cerevisiae) |
|
| chr5_+_45669907 Show fit | 7.80 |
ENSMUST00000117396.1
|
non-SMC condensin I complex, subunit G |
|
| chr9_+_65890237 Show fit | 7.61 |
ENSMUST00000045802.6
|
RIKEN cDNA 2810417H13 gene |
|
| chr5_+_76840597 Show fit | 7.12 |
ENSMUST00000120639.2
ENSMUST00000163347.1 ENSMUST00000121851.1 |
RIKEN cDNA C530008M17 gene |
|
| chr17_+_56303396 Show fit | 6.83 |
ENSMUST00000113038.1
|
ubiquitin-like, containing PHD and RING finger domains, 1 |
|
| chr1_+_180641330 Show fit | 6.79 |
ENSMUST00000085804.5
|
lin-9 homolog (C. elegans) |
|
| chr17_+_56303321 Show fit | 6.52 |
ENSMUST00000001258.8
|
ubiquitin-like, containing PHD and RING finger domains, 1 |
|
| chr13_-_55329723 Show fit | 6.31 |
ENSMUST00000021941.7
|
Max dimerization protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 26.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.0 | 20.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.3 | 20.1 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.8 | 15.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 1.2 | 13.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.2 | 13.1 | GO:0051225 | spindle assembly(GO:0051225) |
| 4.2 | 12.5 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.8 | 11.4 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 1.2 | 11.1 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 2.0 | 10.1 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 37.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 23.9 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.3 | 19.5 | GO:0005657 | replication fork(GO:0005657) |
| 1.8 | 17.9 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 16.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 2.6 | 12.8 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 11.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 1.6 | 11.0 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 10.9 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 9.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 23.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 22.6 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 16.9 | GO:0004386 | helicase activity(GO:0004386) |
| 2.7 | 16.4 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 2.3 | 13.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 2.6 | 12.8 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 12.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.1 | 12.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 11.0 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 10.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 53.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 40.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 24.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 13.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 13.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 12.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 9.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 7.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.3 | 7.1 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 6.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 35.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.4 | 26.6 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 1.1 | 17.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.0 | 17.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.2 | 16.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 13.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.2 | 11.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.5 | 10.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 9.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 9.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |