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avrg: 12D miR HR13_24
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Results for E2f2_E2f5
Z-value: 7.24
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Transcription factors associated with E2f2_E2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.79 | 3.6e-03 | Click! |
| E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.77 | 5.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f2_E2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 43.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.6 | 40.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.8 | 30.8 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 9.3 | 28.0 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 2.2 | 22.1 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 1.7 | 20.0 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 4.6 | 18.4 | GO:0006272 | leading strand elongation(GO:0006272) |
| 2.0 | 17.6 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.3 | 16.9 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 1.4 | 16.8 | GO:0033504 | floor plate development(GO:0033504) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 65.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.7 | 38.0 | GO:0005657 | replication fork(GO:0005657) |
| 0.2 | 30.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 19.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 3.0 | 15.2 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 14.6 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 14.2 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 14.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 2.5 | 12.5 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 2.2 | 11.2 | GO:0031298 | replication fork protection complex(GO:0031298) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.0 | 29.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 2.0 | 28.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 4.6 | 27.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.9 | 26.6 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 3.3 | 20.0 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 1.1 | 19.3 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.1 | 18.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 17.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 3.0 | 15.2 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 77.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.7 | 59.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 28.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.2 | 19.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.2 | 17.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.4 | 17.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 16.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 11.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 10.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.4 | 9.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 81.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 3.5 | 63.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 2.3 | 25.5 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 18.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.7 | 15.4 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.5 | 13.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.3 | 9.3 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.2 | 9.0 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.8 | 8.6 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.2 | 7.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |