Project
avrg: 12D miR HR13_24
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Results for E2f4
Z-value: 3.67
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Transcription factors associated with E2f4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f4 | mm10_v2_chr8_+_105297663_105297742 | 0.70 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_6084983 Show fit | 7.83 |
ENSMUST00000025704.2
|
cell division cycle associated 5 |
|
| chr4_+_134510999 Show fit | 7.49 |
ENSMUST00000105866.2
|
aurora kinase A and ninein interacting protein |
|
| chr8_-_53638945 Show fit | 7.02 |
ENSMUST00000047768.4
|
nei like 3 (E. coli) |
|
| chr18_-_34751502 Show fit | 6.70 |
ENSMUST00000060710.7
|
cell division cycle 25C |
|
| chr1_-_169531343 Show fit | 6.52 |
ENSMUST00000028000.7
|
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
|
| chr14_-_47418407 Show fit | 6.45 |
ENSMUST00000043296.3
|
discs, large (Drosophila) homolog-associated protein 5 |
|
| chr6_+_124830217 Show fit | 6.40 |
ENSMUST00000131847.1
ENSMUST00000151674.1 |
cell division cycle associated 3 |
|
| chr1_-_169531447 Show fit | 6.08 |
ENSMUST00000111368.1
|
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
|
| chr1_-_189688074 Show fit | 5.75 |
ENSMUST00000171929.1
ENSMUST00000165962.1 |
centromere protein F |
|
| chr17_-_25727364 Show fit | 5.24 |
ENSMUST00000170070.1
ENSMUST00000048054.7 |
CTF18, chromosome transmission fidelity factor 18 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.5 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.1 | 11.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.3 | 8.4 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 2.6 | 7.8 | GO:0071922 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.1 | 7.0 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.2 | 6.7 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 0.1 | 6.5 | GO:0007051 | spindle organization(GO:0007051) |
| 0.1 | 5.8 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.6 | 5.2 | GO:1900264 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 1.7 | 5.1 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 12.6 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 10.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 9.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.9 | 7.8 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.3 | 6.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 5.9 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.5 | 5.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.5 | 5.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.6 | 5.2 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.9 | 5.1 | GO:0070531 | BRCA1-A complex(GO:0070531) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 8.8 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.0 | 7.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.4 | 7.0 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.1 | 6.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 5.8 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.5 | 5.2 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 4.8 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 4.7 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.4 | 4.3 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 4.3 | GO:0070182 | DNA polymerase binding(GO:0070182) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.9 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 8.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 7.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 6.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 4.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 3.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.9 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.5 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 8.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 8.8 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.3 | 7.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.7 | 6.7 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 6.3 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.3 | 4.8 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 3.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 3.1 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 3.1 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |