Project
avrg: 12D miR HR13_24
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Results for Ebf1
Z-value: 4.11
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Transcription factors associated with Ebf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf1 | mm10_v2_chr11_+_44617310_44617336 | -0.82 | 1.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_102101310 Show fit | 7.34 |
ENSMUST00000170554.2
ENSMUST00000017460.5 |
pancreatic polypeptide |
|
| chr17_-_25754327 Show fit | 5.32 |
ENSMUST00000075884.6
|
mesothelin |
|
| chr11_+_115154139 Show fit | 4.88 |
ENSMUST00000021076.5
|
RAB37, member of RAS oncogene family |
|
| chr15_-_75566608 Show fit | 4.37 |
ENSMUST00000163116.1
ENSMUST00000023241.5 |
lymphocyte antigen 6 complex, locus H |
|
| chr1_+_171155512 Show fit | 4.30 |
ENSMUST00000111334.1
|
myelin protein zero |
|
| chr7_-_101864093 Show fit | 4.20 |
ENSMUST00000106981.1
|
folate receptor 1 (adult) |
|
| chr15_-_75566811 Show fit | 4.17 |
ENSMUST00000065417.8
|
lymphocyte antigen 6 complex, locus H |
|
| chr4_+_141242850 Show fit | 3.99 |
ENSMUST00000138096.1
ENSMUST00000006618.2 ENSMUST00000125392.1 |
Rho guanine nucleotide exchange factor (GEF) 19 |
|
| chr11_-_31824463 Show fit | 3.80 |
ENSMUST00000129425.1
ENSMUST00000126265.1 |
RIKEN cDNA D630024D03 gene |
|
| chr2_+_180725263 Show fit | 3.67 |
ENSMUST00000094218.3
|
solute carrier family 17, member 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 14.2 | GO:0071231 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231) |
| 0.3 | 9.7 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.4 | 7.5 | GO:0032098 | regulation of appetite(GO:0032098) |
| 1.2 | 7.0 | GO:0002838 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
| 0.4 | 6.8 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 6.8 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 2.2 | 6.7 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
| 0.1 | 6.6 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.4 | 5.5 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.5 | 5.4 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 12.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 11.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 10.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 6.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 5.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 5.7 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.4 | 5.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.3 | 4.6 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.3 | 4.5 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.3 | 14.2 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.2 | 12.9 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 1.6 | 12.7 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.3 | 8.1 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.3 | 7.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.3 | 7.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 7.0 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 6.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 6.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 7.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 4.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.7 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 4.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 4.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 4.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 10.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 6.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 6.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 6.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.4 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 4.1 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 3.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 3.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |