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avrg: 12D miR HR13_24
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Results for Ets1
Z-value: 3.32
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Transcription factors associated with Ets1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ets1 | mm10_v2_chr9_+_32696005_32696121 | -0.81 | 2.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ets1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.6 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.2 | 7.1 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.1 | 6.9 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 1.6 | 6.2 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 1.2 | 5.9 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.0 | 4.9 | GO:0050714 | positive regulation of protein secretion(GO:0050714) |
| 0.3 | 4.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.9 | 4.5 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.8 | 4.5 | GO:0018992 | germ-line sex determination(GO:0018992) |
| 0.4 | 4.2 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.4 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 12.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 12.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.2 | 9.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 8.3 | GO:0005768 | endosome(GO:0005768) |
| 0.3 | 8.2 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 7.4 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 7.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 5.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 4.9 | GO:0042101 | T cell receptor complex(GO:0042101) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 9.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 1.6 | 6.2 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.7 | 5.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 4.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 4.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.4 | 4.6 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.1 | 4.4 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.1 | 4.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 1.1 | 4.2 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.9 | PID EPO PATHWAY | EPO signaling pathway |
| 0.2 | 9.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.2 | 7.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 5.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 4.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 4.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 4.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.5 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 10.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 8.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 6.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 6.3 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 4.6 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.3 | 4.5 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.2 | 4.5 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 4.4 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 4.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |