ISMARA results: Etv1_Etv5

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avrg: 12D miR HR13_24

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Results for Etv1_Etv5_Gabpa

Z-value: 5.34

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Transcription factors associated with Etv1_Etv5_Gabpa

Gene Symbol	Gene ID	Gene Info
Etv1 Ensembl NCBI MGI UniProt	ENSMUSG00000004151.10	ets variant 1
Etv5 Ensembl NCBI MGI UniProt	ENSMUSG00000013089.9	ets variant 5
Gabpa Ensembl NCBI MGI UniProt	ENSMUSG00000008976.10	GA repeat binding protein, alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Gabpa	mm10_v2_chr16_+_84835070_84835124	0.96	2.7e-06	Click!
Etv1	mm10_v2_chr12_+_38783503_38783527	0.96	4.5e-06	Click!
Etv5	mm10_v2_chr16_-_22439719_22439733	-0.90	1.4e-04	Click!

Activity profile of Etv1_Etv5_Gabpa motif

Sorted Z-values of Etv1_Etv5_Gabpa motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_127042420 Show fit	9.91	ENSMUST00000032915.6	Kif22 Ensembl NCBI MGI UniProt Show fit	kinesin family member 22
chr19_+_6084983 Show fit	9.69	ENSMUST00000025704.2	Cdca5 Ensembl NCBI MGI UniProt Show fit	cell division cycle associated 5
chr7_-_122132844 Show fit	9.24	ENSMUST00000106469.1 ENSMUST00000063587.6 ENSMUST00000106468.1 ENSMUST00000130149.1 ENSMUST00000098068.3	Palb2 Ensembl NCBI MGI UniProt Show fit	partner and localizer of BRCA2
chr18_+_36760214 Show fit	8.93	ENSMUST00000049323.7	Wdr55 Ensembl NCBI MGI UniProt Show fit	WD repeat domain 55
chr2_+_118814195 Show fit	8.61	ENSMUST00000110842.1	Knstrn Ensembl NCBI MGI UniProt Show fit	kinetochore-localized astrin/SPAG5 binding
chr17_-_33890584 Show fit	8.48	ENSMUST00000114361.2 ENSMUST00000173492.1	Kifc1 Ensembl NCBI MGI UniProt Show fit	kinesin family member C1
chr2_+_152847961 Show fit	8.27	ENSMUST00000164120.1 ENSMUST00000178997.1 ENSMUST00000109816.1	Tpx2 Ensembl NCBI MGI UniProt Show fit	TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr16_-_18811972 Show fit	8.02	ENSMUST00000000028.7 ENSMUST00000115585.1	Cdc45 Ensembl NCBI MGI UniProt Show fit	cell division cycle 45
chr11_-_94653964 Show fit	7.72	ENSMUST00000039949.4	Eme1 Ensembl NCBI MGI UniProt Show fit	essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr16_+_48994185 Show fit	7.59	ENSMUST00000117994.1 ENSMUST00000048374.5	C330027C09Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA C330027C09 gene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Etv1_Etv5_Gabpa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	70.7	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.3	38.4	GO:0042254	ribosome biogenesis(GO:0042254)
0.1	31.5	GO:0000398	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
1.6	28.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.7	25.9	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.1	22.3	GO:0006412	translation(GO:0006412)
0.2	21.1	GO:0006413	translational initiation(GO:0006413)
0.5	18.8	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
1.0	18.4	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.2	17.3	GO:0008033	tRNA processing(GO:0008033)

Showing 1 to 10 of 616 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	110.6	GO:0005730	nucleolus(GO:0005730)
0.8	61.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.8	41.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.0	32.5	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.7	24.9	GO:0035371	microtubule plus-end(GO:0035371)
0.5	22.2	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.8	20.3	GO:0030686	90S preribosome(GO:0030686)
1.1	20.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.3	19.3	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
1.5	18.6	GO:0005687	U4 snRNP(GO:0005687)

Showing 1 to 10 of 301 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	101.8	GO:0003723	RNA binding(GO:0003723)
0.5	67.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.6	33.1	GO:0019843	rRNA binding(GO:0019843)
0.5	31.5	GO:0003743	translation initiation factor activity(GO:0003743)
1.3	18.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.6	17.7	GO:0070182	DNA polymerase binding(GO:0070182)
1.9	17.3	GO:1990446	U1 snRNP binding(GO:1990446)
0.2	16.4	GO:0003777	microtubule motor activity(GO:0003777)
0.1	16.0	GO:0005096	GTPase activator activity(GO:0005096)
0.6	15.6	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)

Showing 1 to 10 of 394 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	30.3	PID AURORA A PATHWAY	Aurora A signaling
0.6	27.7	PID ATR PATHWAY	ATR signaling pathway
0.5	21.1	PID AURORA B PATHWAY	Aurora B signaling
0.2	19.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.5	15.4	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	11.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	11.4	PID CDC42 PATHWAY	CDC42 signaling events
0.1	8.5	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	5.6	NABA COLLAGENS	Genes encoding collagen proteins
0.1	4.7	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.

Showing 1 to 10 of 70 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	47.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7	46.2	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	29.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.8	26.9	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.8	21.7	REACTOME KINESINS	Genes involved in Kinesins
0.1	21.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.3	20.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.4	20.4	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
1.4	17.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2	15.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport

Showing 1 to 10 of 143 entries

Results for Etv1_Etv5_Gabpa

Z-value: 5.34

Motif logo

Transcription factors associated with Etv1_Etv5_Gabpa

Activity-expression correlation:

Activity profile of Etv1_Etv5_Gabpa motif

Sorted Z-values of Etv1_Etv5_Gabpa motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Etv1_Etv5_Gabpa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: