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avrg: 12D miR HR13_24
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Results for Foxa2_Foxa1
Z-value: 3.57
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Transcription factors associated with Foxa2_Foxa1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxa2 | mm10_v2_chr2_-_148045891_148045948 | -0.82 | 1.9e-03 | Click! |
| Foxa1 | mm10_v2_chr12_-_57546121_57546141 | -0.47 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_104766308 Show fit | 19.00 |
ENSMUST00000031663.3
|
complement component 8, beta polypeptide |
|
| chr4_+_104766334 Show fit | 18.22 |
ENSMUST00000065072.6
|
complement component 8, beta polypeptide |
|
| chr2_-_62483637 Show fit | 11.56 |
ENSMUST00000136686.1
ENSMUST00000102733.3 |
glucagon |
|
| chr10_+_115817247 Show fit | 8.66 |
ENSMUST00000035563.7
ENSMUST00000080630.3 ENSMUST00000179196.1 |
tetraspanin 8 |
|
| chr4_-_57916283 Show fit | 8.23 |
ENSMUST00000063816.5
|
RIKEN cDNA D630039A03 gene |
|
| chr5_-_86906937 Show fit | 7.63 |
ENSMUST00000031181.9
ENSMUST00000113333.1 |
UDP glucuronosyltransferase 2 family, polypeptide B34 |
|
| chrX_-_108664891 Show fit | 6.34 |
ENSMUST00000178160.1
|
predicted gene 379 |
|
| chr3_-_113532288 Show fit | 6.26 |
ENSMUST00000132353.1
|
amylase 2a1 |
|
| chr6_+_90619241 Show fit | 5.35 |
ENSMUST00000032177.8
|
solute carrier family 41, member 3 |
|
| chr14_+_41131777 Show fit | 5.32 |
ENSMUST00000022314.3
ENSMUST00000170719.1 |
surfactant associated protein A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxa2_Foxa1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 37.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.7 | 11.6 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 1.0 | 8.9 | GO:0008228 | opsonization(GO:0008228) |
| 0.2 | 8.7 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.4 | 5.8 | GO:0070842 | aggresome assembly(GO:0070842) |
| 1.1 | 5.3 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 1.3 | 5.0 | GO:0015801 | aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827) |
| 0.6 | 5.0 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.3 | 4.4 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 4.3 | GO:0009166 | nucleotide catabolic process(GO:0009166) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 37.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 18.8 | GO:0009986 | cell surface(GO:0009986) |
| 0.2 | 8.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.3 | 5.8 | GO:0005922 | connexon complex(GO:0005922) |
| 0.2 | 4.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.5 | 4.1 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.0 | 3.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.5 | 3.5 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.3 | 3.1 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.5 | GO:0032403 | protein complex binding(GO:0032403) |
| 0.1 | 11.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 10.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 7.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.0 | 6.7 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.2 | 5.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 1.8 | 5.3 | GO:0045352 | interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 receptor antagonist activity(GO:0005152) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353) |
| 1.3 | 5.0 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.7 | 5.0 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.1 | 4.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 5.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 3.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 3.3 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 2.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 2.2 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 2.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.9 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 35.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.7 | 11.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 5.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 4.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 4.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 4.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 3.7 | REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | Genes involved in Class I MHC mediated antigen processing & presentation |
| 0.2 | 3.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 3.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |