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avrg: 12D miR HR13_24
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Results for Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 7.35
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Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000031386.8 | host cell factor C1 | |
| ENSMUSG00000040841.5 | sine oculis-related homeobox 5 | |
| ENSMUSG00000025369.8 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | |
| ENSMUSG00000061079.7 | zinc finger protein 143 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hcfc1 | mm10_v2_chrX_-_73966329_73966376 | 0.97 | 1.0e-06 | Click! |
| Zfp143 | mm10_v2_chr7_+_110061702_110061732 | 0.94 | 2.2e-05 | Click! |
| Smarcc2 | mm10_v2_chr10_+_128459236_128459248 | 0.91 | 9.4e-05 | Click! |
| Six5 | mm10_v2_chr7_+_19094594_19094633 | -0.69 | 1.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_90784738 Show fit | 11.15 |
ENSMUST00000179483.1
|
erythroid differentiation regulator 1 |
|
| chr6_+_124829540 Show fit | 10.25 |
ENSMUST00000150120.1
|
cell division cycle associated 3 |
|
| chr2_+_118598209 Show fit | 9.50 |
ENSMUST00000038341.7
|
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) |
|
| chr2_+_152847961 Show fit | 8.14 |
ENSMUST00000164120.1
ENSMUST00000178997.1 ENSMUST00000109816.1 |
TPX2, microtubule-associated protein homolog (Xenopus laevis) |
|
| chr5_+_33658123 Show fit | 7.69 |
ENSMUST00000074849.6
ENSMUST00000079534.4 |
transforming, acidic coiled-coil containing protein 3 |
|
| chr2_+_152847993 Show fit | 7.37 |
ENSMUST00000028969.8
|
TPX2, microtubule-associated protein homolog (Xenopus laevis) |
|
| chr7_+_29307924 Show fit | 7.31 |
ENSMUST00000108230.1
ENSMUST00000065181.5 |
D4, zinc and double PHD fingers family 1 |
|
| chr11_+_117849223 Show fit | 6.96 |
ENSMUST00000081387.4
|
baculoviral IAP repeat-containing 5 |
|
| chr8_+_71464910 Show fit | 6.91 |
ENSMUST00000048914.6
|
mitochondrial ribosomal protein L34 |
|
| chr6_+_124829582 Show fit | 6.69 |
ENSMUST00000024270.7
|
cell division cycle associated 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 30.7 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.2 | 16.1 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 1.9 | 13.1 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 2.0 | 12.1 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 1.6 | 10.9 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.9 | 10.5 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 10.2 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 0.8 | 10.0 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.3 | 10.0 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.9 | 9.9 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.8 | 19.4 | GO:0071565 | nBAF complex(GO:0071565) |
| 3.0 | 18.0 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 17.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.9 | 15.5 | GO:0005818 | aster(GO:0005818) |
| 0.3 | 13.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 12.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.8 | 10.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 10.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 1.0 | 10.0 | GO:0070545 | PeBoW complex(GO:0070545) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 44.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.5 | 24.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 24.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.6 | 14.0 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 2.0 | 12.1 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.0 | 10.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.9 | 9.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 1.4 | 9.5 | GO:0048256 | flap endonuclease activity(GO:0048256) |
| 0.6 | 8.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.3 | 8.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 47.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.6 | 23.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 16.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 13.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 8.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 6.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 6.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 6.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 5.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 4.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 36.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 19.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.9 | 16.9 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.6 | 12.3 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.5 | 12.2 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.6 | 9.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.6 | 9.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 9.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.4 | 8.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 7.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |