ISMARA results: Max

Project

avrg: 12D miR HR13_24

Navigation

Downloads

Results for Max_Mycn

Z-value: 10.74

Motif logo

Transcription factors associated with Max_Mycn

Gene Symbol	Gene ID	Gene Info
Max Ensembl NCBI MGI UniProt	ENSMUSG00000059436.6	Max protein
Mycn Ensembl NCBI MGI UniProt	ENSMUSG00000037169.8	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Max	mm10_v2_chr12_-_76962178_76962248	0.98	2.0e-07	Click!
Mycn	mm10_v2_chr12_-_12940600_12940616	0.39	2.4e-01	Click!

Activity profile of Max_Mycn motif

Sorted Z-values of Max_Mycn motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_104638658 Show fit	28.22	ENSMUST00000046212.1	Slc16a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 16 (monocarboxylic acid transporters), member 1
chr8_+_48109949 Show fit	21.18	ENSMUST00000170263.2 ENSMUST00000033966.6	Dctd Ensembl NCBI MGI UniProt Show fit	dCMP deaminase
chr5_-_135251209 Show fit	19.67	ENSMUST00000062572.2	Fzd9 Ensembl NCBI MGI UniProt Show fit	frizzled homolog 9 (Drosophila)
chr8_+_48110156 Show fit	14.14	ENSMUST00000174379.1	Dctd Ensembl NCBI MGI UniProt Show fit	dCMP deaminase
chr9_+_107587711 Show fit	13.12	ENSMUST00000010192.5	Ifrd2 Ensembl NCBI MGI UniProt Show fit	interferon-related developmental regulator 2
chrX_-_51681703 Show fit	12.44	ENSMUST00000088172.5	Hs6st2 Ensembl NCBI MGI UniProt Show fit	heparan sulfate 6-O-sulfotransferase 2
chr12_-_72917872 Show fit	12.06	ENSMUST00000044000.5	4930447C04Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4930447C04 gene
chr4_+_124657646 Show fit	11.91	ENSMUST00000053491.7	Pou3f1 Ensembl NCBI MGI UniProt Show fit	POU domain, class 3, transcription factor 1
chr12_-_72917760 Show fit	11.84	ENSMUST00000110489.2	4930447C04Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4930447C04 gene
chr5_-_33433976 Show fit	11.59	ENSMUST00000173348.1	Nkx1-1 Ensembl NCBI MGI UniProt Show fit	NK1 transcription factor related, locus 1 (Drosophila)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Max_Mycn

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
11.8	35.3	GO:0006226	dUMP biosynthetic process(GO:0006226)
1.3	31.3	GO:0000154	rRNA modification(GO:0000154)
1.5	28.8	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
2.8	28.2	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.4	25.5	GO:0048642	negative regulation of skeletal muscle tissue development(GO:0048642)
4.8	24.1	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
8.0	23.9	GO:0010705	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705)
1.1	20.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
6.6	19.7	GO:1990523	bone regeneration(GO:1990523)
0.5	18.9	GO:0030490	maturation of SSU-rRNA(GO:0030490)

Showing 1 to 10 of 659 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	67.7	GO:0005730	nucleolus(GO:0005730)
0.3	43.6	GO:0001650	fibrillar center(GO:0001650)
0.5	31.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.6	30.6	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
4.3	29.8	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.3	26.9	GO:0005759	mitochondrial matrix(GO:0005759)
0.7	26.4	GO:0035371	microtubule plus-end(GO:0035371)
0.1	26.4	GO:0005813	centrosome(GO:0005813)
0.2	21.9	GO:0005840	ribosome(GO:0005840)
0.3	21.7	GO:0005657	replication fork(GO:0005657)

Showing 1 to 10 of 280 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	53.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	31.2	GO:0003723	RNA binding(GO:0003723)
4.0	28.2	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.7	26.7	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.5	25.6	GO:0030332	cyclin binding(GO:0030332)
0.3	25.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.4	22.4	GO:1990226	histone methyltransferase binding(GO:1990226)
0.8	21.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	20.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8	20.0	GO:0003746	translation elongation factor activity(GO:0003746)

Showing 1 to 10 of 440 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	53.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.6	29.9	PID AURORA B PATHWAY	Aurora B signaling
0.1	21.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	20.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	16.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	16.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	12.7	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	11.5	PID MTOR 4PATHWAY	mTOR signaling pathway
0.3	11.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	10.6	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 71 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	50.4	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5	48.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.8	43.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.5	36.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.8	28.4	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
2.1	27.7	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.9	26.8	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.5	25.6	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.8	25.4	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.2	22.5	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)

Showing 1 to 10 of 130 entries

Results for Max_Mycn

Z-value: 10.74

Motif logo

Transcription factors associated with Max_Mycn

Activity-expression correlation:

Activity profile of Max_Mycn motif

Sorted Z-values of Max_Mycn motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Max_Mycn

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: