ISMARA results: Mnx1_Lhx6

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avrg: 12D miR HR13_24

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Results for Mnx1_Lhx6_Lmx1a

Z-value: 2.41

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Transcription factors associated with Mnx1_Lhx6_Lmx1a

Gene Symbol	Gene ID	Gene Info
Mnx1 Ensembl NCBI MGI UniProt	ENSMUSG00000001566.8	motor neuron and pancreas homeobox 1
Lhx6 Ensembl NCBI MGI UniProt	ENSMUSG00000026890.13	LIM homeobox protein 6
Lmx1a Ensembl NCBI MGI UniProt	ENSMUSG00000026686.8	LIM homeobox transcription factor 1 alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mnx1	mm10_v2_chr5_-_29478470_29478597	0.87	5.4e-04	Click!
Lmx1a	mm10_v2_chr1_+_167689552_167689563	0.68	2.1e-02	Click!
Lhx6	mm10_v2_chr2_-_36104060_36104073	0.66	2.7e-02	Click!

Activity profile of Mnx1_Lhx6_Lmx1a motif

Sorted Z-values of Mnx1_Lhx6_Lmx1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_25372315 Show fit	4.48	ENSMUST00000028329.6 ENSMUST00000114293.2 ENSMUST00000100323.2	Sapcd2 Ensembl NCBI MGI UniProt Show fit	suppressor APC domain containing 2
chr10_+_4611971 Show fit	4.19	ENSMUST00000105590.1 ENSMUST00000067086.7	Esr1 Ensembl NCBI MGI UniProt Show fit	estrogen receptor 1 (alpha)
chr3_-_49757257 Show fit	4.19	ENSMUST00000035931.7	Pcdh18 Ensembl NCBI MGI UniProt Show fit	protocadherin 18
chr9_+_65890237 Show fit	4.02	ENSMUST00000045802.6	2810417H13Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2810417H13 gene
chr18_+_23415400 Show fit	3.99	ENSMUST00000115832.2 ENSMUST00000047954.7	Dtna Ensembl NCBI MGI UniProt Show fit	dystrobrevin alpha
chr16_-_45724600 Show fit	3.86	ENSMUST00000096057.4	Tagln3 Ensembl NCBI MGI UniProt Show fit	transgelin 3
chr9_+_32116040 Show fit	3.42	ENSMUST00000174641.1	Arhgap32 Ensembl NCBI MGI UniProt Show fit	Rho GTPase activating protein 32
chr15_-_79285502 Show fit	3.13	ENSMUST00000165408.1	Baiap2l2 Ensembl NCBI MGI UniProt Show fit	BAI1-associated protein 2-like 2
chr9_+_72806874 Show fit	2.90	ENSMUST00000055535.8	Prtg Ensembl NCBI MGI UniProt Show fit	protogenin homolog (Gallus gallus)
chr15_-_79285470 Show fit	2.66	ENSMUST00000170955.1	Baiap2l2 Ensembl NCBI MGI UniProt Show fit	BAI1-associated protein 2-like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mnx1_Lhx6_Lmx1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.8	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.8	4.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.2	4.2	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3	3.9	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1	3.4	GO:1905000	regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0	3.3	GO:0032411	positive regulation of transporter activity(GO:0032411)
0.0	3.1	GO:0007266	Rho protein signal transduction(GO:0007266)
0.1	2.8	GO:0006182	cGMP biosynthetic process(GO:0006182)
0.9	2.6	GO:0070173	regulation of enamel mineralization(GO:0070173)
0.8	2.4	GO:0010133	proline catabolic process to glutamate(GO:0010133)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	5.8	GO:0071439	clathrin complex(GO:0071439)
0.3	5.8	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.6	4.2	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.0	3.7	GO:0001650	fibrillar center(GO:0001650)
0.0	3.6	GO:0043209	myelin sheath(GO:0043209)
0.7	3.4	GO:0031523	Myb complex(GO:0031523)
0.1	3.2	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	3.1	GO:0031594	neuromuscular junction(GO:0031594)
0.0	2.9	GO:0008021	synaptic vesicle(GO:0008021)
0.1	2.8	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.0	GO:0005543	phospholipid binding(GO:0005543)
0.0	4.3	GO:0051015	actin filament binding(GO:0051015)
1.4	4.2	GO:0031798	type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1	3.8	GO:0001540	beta-amyloid binding(GO:0001540)
0.1	3.7	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7	3.4	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.1	3.4	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	3.2	GO:0030165	PDZ domain binding(GO:0030165)
0.1	2.9	GO:0071949	FAD binding(GO:0071949)
0.1	2.8	GO:0004383	guanylate cyclase activity(GO:0004383)

Showing 1 to 10 of 85 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.7	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	3.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	3.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	3.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	2.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.5	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	1.4	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	1.4	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	1.3	PID RAC1 PATHWAY	RAC1 signaling pathway

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	5.4	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.1	2.1	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	2.0	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	1.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	1.2	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	1.1	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	1.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 34 entries

Results for Mnx1_Lhx6_Lmx1a

Z-value: 2.41

Motif logo

Transcription factors associated with Mnx1_Lhx6_Lmx1a

Activity-expression correlation:

Activity profile of Mnx1_Lhx6_Lmx1a motif

Sorted Z-values of Mnx1_Lhx6_Lmx1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mnx1_Lhx6_Lmx1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: