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avrg: 12D miR HR13_24
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Results for Nkx3-2
Z-value: 2.91
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Transcription factors associated with Nkx3-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx3-2 | mm10_v2_chr5_-_41764493_41764496 | 0.55 | 7.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx3-2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.0 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
| 0.6 | 5.5 | GO:0015727 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.9 | 4.6 | GO:0071104 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
| 0.9 | 4.5 | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) |
| 1.4 | 4.2 | GO:0031283 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.5 | 4.2 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 1.0 | 4.0 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.1 | 3.5 | GO:0032825 | positive regulation of natural killer cell differentiation(GO:0032825) |
| 1.1 | 3.4 | GO:0070844 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) |
| 0.5 | 2.6 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 5.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.6 | 4.2 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.3 | 4.2 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 4.0 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 3.4 | GO:0016235 | aggresome(GO:0016235) |
| 0.4 | 2.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 2.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 2.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 2.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.7 | 6.9 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 5.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.8 | 5.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.3 | 4.6 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.7 | 4.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.0 | 4.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.8 | 3.4 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.5 | 2.6 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
| 0.2 | 2.6 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 3.2 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.5 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 3.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 2.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 2.0 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.6 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 1.5 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 1.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |