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avrg: 12D miR HR13_24

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Results for Nr0b1

Z-value: 0.49

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Transcription factors associated with Nr0b1

Gene Symbol Gene ID Gene Info
Nr0b1
ENSMUSG00000025056.4 nuclear receptor subfamily 0, group B, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_86191782-0.595.5e-02Click!

Activity profile of Nr0b1 motif

Sorted Z-values of Nr0b1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_144332146 0.76 ENSMUST00000037423.3
Ovol2
ovo-like 2 (Drosophila)
chr2_-_144331695 0.70 ENSMUST00000103171.3
Ovol2
ovo-like 2 (Drosophila)
chr4_-_11386679 0.68 ENSMUST00000043781.7
ENSMUST00000108310.1
Esrp1
epithelial splicing regulatory protein 1
chr5_+_30913398 0.41 ENSMUST00000031055.5
Emilin1
elastin microfibril interfacer 1
chr4_-_11386394 0.39 ENSMUST00000155519.1
Esrp1
epithelial splicing regulatory protein 1
chr7_+_19359740 0.37 ENSMUST00000140836.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr2_-_65238573 0.30 ENSMUST00000090896.3
ENSMUST00000155082.1
Cobll1
Cobl-like 1
chr2_-_65238625 0.30 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
Cobll1
Cobl-like 1
chr4_+_116221590 0.27 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr15_+_98634743 0.26 ENSMUST00000003442.7
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr4_+_116221689 0.25 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr7_+_19094594 0.24 ENSMUST00000049454.5
Six5
sine oculis-related homeobox 5
chr4_+_116221633 0.24 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr5_-_107726017 0.21 ENSMUST00000159263.2
Gfi1
growth factor independent 1
chr16_-_20621255 0.21 ENSMUST00000052939.2
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr2_+_71786923 0.20 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6
integrin alpha 6
chr9_+_80165079 0.19 ENSMUST00000184480.1
Myo6
myosin VI
chr2_+_157279065 0.18 ENSMUST00000029171.5
Rpn2
ribophorin II
chr16_-_45844303 0.18 ENSMUST00000036355.6
Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844228 0.18 ENSMUST00000076333.5
Phldb2
pleckstrin homology-like domain, family B, member 2
chr6_+_134830145 0.17 ENSMUST00000046303.5
Crebl2
cAMP responsive element binding protein-like 2
chr3_-_152166230 0.16 ENSMUST00000046614.9
Gipc2
GIPC PDZ domain containing family, member 2
chr17_+_29490812 0.16 ENSMUST00000024811.6
Pim1
proviral integration site 1
chrX_-_145505175 0.15 ENSMUST00000143610.1
Amot
angiomotin
chr1_+_88087802 0.15 ENSMUST00000113139.1
Ugt1a8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr6_+_28981490 0.14 ENSMUST00000164104.1
Gm3294
predicted gene 3294
chr6_+_134830216 0.14 ENSMUST00000111937.1
Crebl2
cAMP responsive element binding protein-like 2
chr2_+_157279026 0.13 ENSMUST00000116380.2
Rpn2
ribophorin II
chr9_+_80165013 0.13 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6
myosin VI
chr5_+_64803513 0.11 ENSMUST00000165536.1
Klf3
Kruppel-like factor 3 (basic)
chr2_+_129198757 0.11 ENSMUST00000028880.3
Slc20a1
solute carrier family 20, member 1
chr17_-_80728026 0.10 ENSMUST00000112389.2
ENSMUST00000025089.7
Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
chr11_+_94328242 0.09 ENSMUST00000021227.5
Ankrd40
ankyrin repeat domain 40
chr15_+_35371498 0.09 ENSMUST00000048646.7
Vps13b
vacuolar protein sorting 13B (yeast)
chr16_+_44173239 0.09 ENSMUST00000119746.1
Gm608
predicted gene 608
chr13_-_64274879 0.08 ENSMUST00000109770.1
Cdc14b
CDC14 cell division cycle 14B
chr13_-_31559333 0.08 ENSMUST00000170573.1
A530084C06Rik
RIKEN cDNA A530084C06 gene
chr3_+_86224665 0.07 ENSMUST00000107635.1
Lrba
LPS-responsive beige-like anchor
chr13_-_94358818 0.07 ENSMUST00000059598.2
Gm9776
predicted gene 9776
chr8_-_95434869 0.07 ENSMUST00000034249.6
Gtl3
gene trap locus 3
chr6_+_47454320 0.07 ENSMUST00000031697.8
Cul1
cullin 1
chr3_+_89715016 0.07 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr2_+_153842981 0.06 ENSMUST00000175856.1
Efcab8
EF-hand calcium binding domain 8
chr5_+_31193227 0.06 ENSMUST00000031029.8
ENSMUST00000133711.1
ENSMUST00000132471.1
Snx17
sorting nexin 17
chr11_+_107547925 0.06 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
Helz
helicase with zinc finger domain
chr10_+_39732099 0.05 ENSMUST00000019986.6
Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr7_-_65371210 0.05 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr4_-_129696817 0.05 ENSMUST00000102588.3
Tmem39b
transmembrane protein 39b
chr15_-_81697256 0.05 ENSMUST00000072910.5
Chadl
chondroadherin-like
chr3_-_107458895 0.05 ENSMUST00000009617.8
Kcnc4
potassium voltage gated channel, Shaw-related subfamily, member 4
chr17_-_26508463 0.05 ENSMUST00000025025.6
Dusp1
dual specificity phosphatase 1
chr17_+_88530113 0.05 ENSMUST00000038551.6
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chr2_-_80581234 0.05 ENSMUST00000028386.5
Nckap1
NCK-associated protein 1
chr11_+_94327984 0.05 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40
ankyrin repeat domain 40
chr3_+_54156039 0.04 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr10_-_81350389 0.04 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b
high mobility group 20B
chr18_+_35829798 0.04 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr10_-_128589650 0.04 ENSMUST00000082059.6
Erbb3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr6_-_52191695 0.04 ENSMUST00000101395.2
Hoxa4
homeobox A4
chr9_+_110333402 0.04 ENSMUST00000133114.1
ENSMUST00000125759.1
Scap
SREBF chaperone
chr5_+_121711609 0.04 ENSMUST00000051950.7
Atxn2
ataxin 2
chr13_-_14063395 0.03 ENSMUST00000170957.1
Ggps1
geranylgeranyl diphosphate synthase 1
chr4_-_132422484 0.03 ENSMUST00000102568.3
Phactr4
phosphatase and actin regulator 4
chr3_-_123690806 0.03 ENSMUST00000154668.1
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr2_-_157279519 0.03 ENSMUST00000143663.1
Mroh8
maestro heat-like repeat family member 8
chr4_-_118134869 0.03 ENSMUST00000097912.1
ENSMUST00000030263.2
ENSMUST00000106410.1
St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
chr2_-_80581380 0.03 ENSMUST00000111760.2
Nckap1
NCK-associated protein 1
chr7_+_79500081 0.03 ENSMUST00000181511.2
ENSMUST00000182937.1
AI854517
expressed sequence AI854517
chr17_+_34898463 0.03 ENSMUST00000114033.2
ENSMUST00000078061.6
Ehmt2
euchromatic histone lysine N-methyltransferase 2
chr4_-_132422394 0.02 ENSMUST00000152271.1
ENSMUST00000084170.5
Phactr4
phosphatase and actin regulator 4
chr15_+_80711292 0.02 ENSMUST00000067689.7
Tnrc6b
trinucleotide repeat containing 6b
chr13_+_94358943 0.02 ENSMUST00000022196.3
Ap3b1
adaptor-related protein complex 3, beta 1 subunit
chr15_-_38078842 0.02 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr8_+_71371283 0.02 ENSMUST00000110051.1
ENSMUST00000002469.8
ENSMUST00000110052.1
Ocel1
occludin/ELL domain containing 1
chr1_+_162570687 0.01 ENSMUST00000050010.4
ENSMUST00000150040.1
Vamp4
vesicle-associated membrane protein 4
chr4_-_123750236 0.01 ENSMUST00000102636.3
Akirin1
akirin 1
chr11_+_105181527 0.01 ENSMUST00000106941.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr10_+_90829538 0.01 ENSMUST00000179694.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr1_+_140246216 0.01 ENSMUST00000119786.1
ENSMUST00000120796.1
ENSMUST00000060201.8
ENSMUST00000120709.1
Kcnt2
potassium channel, subfamily T, member 2
chr5_-_137531952 0.01 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr9_-_44881274 0.01 ENSMUST00000002095.3
ENSMUST00000114689.1
ENSMUST00000128768.1
Kmt2a
lysine (K)-specific methyltransferase 2A
chr2_+_59160884 0.01 ENSMUST00000037903.8
Pkp4
plakophilin 4
chr19_+_45015198 0.00 ENSMUST00000179108.1
Lzts2
leucine zipper, putative tumor suppressor 2
chr14_+_70457447 0.00 ENSMUST00000003561.3
Phyhip
phytanoyl-CoA hydroxylase interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr0b1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0060214 endocardium formation(GO:0060214)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.2 GO:0070103 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 1.1 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.2 GO:2000138 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.3 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577)
0.0 0.2 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0 0.0 GO:1904057 negative regulation of sensory perception of pain(GO:1904057)
0.0 0.8 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.4 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0008078 mesodermal cell migration(GO:0008078)
0.0 0.1 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation