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avrg: 12D miR HR13_24
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Results for Nrf1
Z-value: 4.53
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | mm10_v2_chr6_+_30047979_30048049 | 0.87 | 4.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 11.5 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.0 | 8.3 | GO:0000398 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.5 | 6.5 | GO:0019985 | translesion synthesis(GO:0019985) |
| 1.6 | 6.4 | GO:0051316 | attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316) |
| 0.1 | 6.2 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 5.4 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 1.3 | 5.3 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.1 | 5.2 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.1 | 5.2 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.4 | 4.6 | GO:1904869 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 17.1 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 8.6 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 7.9 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.5 | 7.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 7.1 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 6.6 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.5 | 6.1 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939) |
| 0.1 | 5.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.9 | 5.6 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.6 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 10.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 10.2 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.4 | 9.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 8.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.9 | 7.1 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 6.9 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 5.5 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 5.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 5.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 9.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 8.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 4.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 4.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 3.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 3.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 8.4 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 8.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 7.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.7 | 7.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 6.5 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.4 | 6.4 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.3 | 6.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.1 | 6.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 5.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |