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avrg: 12D miR HR13_24
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Results for Smad1
Z-value: 2.31
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Transcription factors associated with Smad1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad1 | mm10_v2_chr8_-_79399513_79399532 | -0.93 | 2.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_24777172 Show fit | 3.61 |
ENSMUST00000038069.7
|
carcinoembryonic antigen-related cell adhesion molecule 10 |
|
| chr16_+_32756336 Show fit | 3.41 |
ENSMUST00000135753.1
|
mucin 4 |
|
| chr19_+_4081565 Show fit | 3.20 |
ENSMUST00000159593.1
|
calcium binding protein 2 |
|
| chr13_-_3945349 Show fit | 3.04 |
ENSMUST00000058610.7
|
urocortin 3 |
|
| chr19_+_4082473 Show fit | 2.73 |
ENSMUST00000159148.1
|
calcium binding protein 2 |
|
| chr12_-_24680890 Show fit | 2.69 |
ENSMUST00000156453.2
|
cystin 1 |
|
| chr6_-_55175019 Show fit | 2.59 |
ENSMUST00000003569.5
|
indolethylamine N-methyltransferase |
|
| chr10_-_75797728 Show fit | 2.22 |
ENSMUST00000139724.1
|
glutathione S-transferase, theta 1 |
|
| chr2_-_93452679 Show fit | 2.19 |
ENSMUST00000111257.1
ENSMUST00000145553.1 |
CD82 antigen |
|
| chr11_+_49794157 Show fit | 1.98 |
ENSMUST00000020629.4
|
glutamine fructose-6-phosphate transaminase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Smad1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.7 | GO:0002835 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
| 0.2 | 4.4 | GO:0046466 | membrane lipid catabolic process(GO:0046466) |
| 0.2 | 4.0 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.4 | 3.5 | GO:0071231 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231) |
| 0.3 | 3.4 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.2 | 3.4 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.0 | 3.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.3 | 3.1 | GO:0015691 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.0 | 3.1 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.4 | 2.9 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.4 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 4.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 4.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 3.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.2 | 3.2 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 3.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.2 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 3.1 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.1 | 2.9 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 2.9 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 5.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 4.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 1.1 | 4.3 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.2 | 4.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.5 | 3.2 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.1 | 3.1 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.4 | 3.0 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) |
| 0.3 | 2.9 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.7 | 2.7 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 3.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.0 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 2.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 4.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 4.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 4.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 3.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 3.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 3.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 2.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |