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avrg: 12D miR HR13_24
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Results for Smad3
Z-value: 2.36
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Transcription factors associated with Smad3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad3 | mm10_v2_chr9_-_63757933_63757994 | -0.25 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_100779074 Show fit | 4.22 |
ENSMUST00000110073.1
ENSMUST00000110070.1 |
RIKEN cDNA 9030617O03 gene |
|
| chr12_+_100779088 Show fit | 3.87 |
ENSMUST00000110069.1
|
RIKEN cDNA 9030617O03 gene |
|
| chr12_+_100779055 Show fit | 3.73 |
ENSMUST00000069782.4
|
RIKEN cDNA 9030617O03 gene |
|
| chr2_-_152831665 Show fit | 2.47 |
ENSMUST00000156688.1
ENSMUST00000007803.5 |
BCL2-like 1 |
|
| chr2_-_152831112 Show fit | 2.32 |
ENSMUST00000128172.1
|
BCL2-like 1 |
|
| chr13_+_21735055 Show fit | 2.24 |
ENSMUST00000087714.4
|
histone cluster 1, H4j |
|
| chr12_-_76795489 Show fit | 2.08 |
ENSMUST00000082431.3
|
glutathione peroxidase 2 |
|
| chr13_+_23531044 Show fit | 1.91 |
ENSMUST00000102972.3
|
histone cluster 1, H4h |
|
| chr13_-_21750505 Show fit | 1.75 |
ENSMUST00000102983.1
|
histone cluster 1, H4k |
|
| chr13_-_21832194 Show fit | 1.72 |
ENSMUST00000102979.1
|
histone cluster 1, H4n |
Network of associatons between targets according to the STRING database.
First level regulatory network of Smad3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.0 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 5.7 | GO:0006342 | chromatin silencing(GO:0006342) |
| 1.2 | 4.8 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.0 | 2.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 2.1 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.1 | 2.0 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 1.9 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.0 | 1.7 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.1 | 0.9 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.1 | 0.9 | GO:0097369 | sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 6.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.4 | 4.8 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.6 | GO:0005930 | axoneme(GO:0005930) |
| 0.0 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.5 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.5 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 0.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 4.8 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 2.1 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 1.9 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.9 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.2 | 0.7 | GO:0015065 | uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553) |
| 0.0 | 0.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.5 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.1 | 0.4 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 0.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.9 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 4.8 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 1.1 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 0.5 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.0 | 0.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |