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avrg: 12D miR HR13_24
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Results for Snai1_Zeb1_Snai2
Z-value: 12.49
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Transcription factors associated with Snai1_Zeb1_Snai2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zeb1 | mm10_v2_chr18_+_5591860_5591902 | -0.94 | 1.2e-05 | Click! |
| Snai2 | mm10_v2_chr16_+_14705832_14705858 | -0.79 | 3.5e-03 | Click! |
| Snai1 | mm10_v2_chr2_+_167538192_167538210 | -0.73 | 1.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Snai1_Zeb1_Snai2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 79.4 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 3.7 | 70.3 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.5 | 62.7 | GO:0002793 | positive regulation of peptide secretion(GO:0002793) positive regulation of peptide hormone secretion(GO:0090277) |
| 7.8 | 46.7 | GO:0018992 | germ-line sex determination(GO:0018992) |
| 3.6 | 39.1 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 2.8 | 34.1 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.6 | 33.1 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 10.5 | 31.5 | GO:0042323 | negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 5.0 | 29.9 | GO:0032439 | endosome localization(GO:0032439) |
| 6.4 | 25.8 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 455.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 3.4 | 88.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 9.3 | 74.5 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.4 | 61.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 1.3 | 47.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.8 | 44.3 | GO:0031901 | early endosome membrane(GO:0031901) |
| 2.5 | 34.5 | GO:0045179 | apical cortex(GO:0045179) |
| 2.3 | 33.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.3 | 30.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 27.9 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 61.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.3 | 58.7 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.1 | 48.7 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 12.1 | 48.3 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.8 | 43.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 4.9 | 39.4 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.5 | 37.3 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.8 | 33.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.5 | 32.2 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 2.0 | 31.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 69.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 24.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 24.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.5 | 17.5 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.3 | 15.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.4 | 15.1 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.3 | 13.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 12.6 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.2 | 12.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.5 | 10.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 144.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 3.0 | 48.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 45.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 2.2 | 44.6 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 1.4 | 28.5 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 1.9 | 26.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 25.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.2 | 23.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 1.2 | 22.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 22.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |