Project
avrg: 12D miR HR13_24
Navigation
Downloads
Results for Tbx15
Z-value: 2.98
Motif logo
Transcription factors associated with Tbx15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx15 | mm10_v2_chr3_+_99253754_99253807 | 0.83 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbx15
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.4 | GO:0031283 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.3 | 9.2 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.7 | 6.7 | GO:0033227 | dsRNA transport(GO:0033227) |
| 1.1 | 5.5 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
| 0.4 | 5.0 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.5 | 4.7 | GO:0036006 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
| 0.1 | 4.6 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.1 | 4.3 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 3.5 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.3 | 3.4 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 14.4 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 6.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 5.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 5.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.8 | 5.5 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.2 | 4.1 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.2 | 3.6 | GO:0043196 | varicosity(GO:0043196) |
| 0.6 | 3.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 3.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 2.7 | GO:0030017 | sarcomere(GO:0030017) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.0 | GO:0003779 | actin binding(GO:0003779) |
| 1.1 | 6.7 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.1 | 5.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 1.8 | 5.5 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.7 | 4.7 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 4.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 3.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.8 | 3.3 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 3.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 3.3 | GO:0001047 | core promoter binding(GO:0001047) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 5.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 2.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 7.7 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 4.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 3.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 3.1 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 3.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |