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avrg: 12D miR HR13_24
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Results for Tfdp1_Wt1_Egr2
Z-value: 7.01
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Transcription factors associated with Tfdp1_Wt1_Egr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfdp1 | mm10_v2_chr8_+_13339656_13339674 | 0.89 | 2.6e-04 | Click! |
| Egr2 | mm10_v2_chr10_+_67535465_67535492 | 0.70 | 1.7e-02 | Click! |
| Wt1 | mm10_v2_chr2_+_105130883_105130981 | -0.56 | 7.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_108275409 Show fit | 18.04 |
ENSMUST00000136175.1
|
coiled-coil domain containing 85C |
|
| chr4_+_124657646 Show fit | 16.23 |
ENSMUST00000053491.7
|
POU domain, class 3, transcription factor 1 |
|
| chr11_+_77930800 Show fit | 15.40 |
ENSMUST00000093995.3
ENSMUST00000000646.7 |
seizure related gene 6 |
|
| chr7_+_46396439 Show fit | 12.94 |
ENSMUST00000025202.6
|
potassium voltage gated channel, Shaw-related subfamily, member 1 |
|
| chr6_+_120666388 Show fit | 11.65 |
ENSMUST00000112686.1
|
cat eye syndrome chromosome region, candidate 2 |
|
| chr9_-_22052021 Show fit | 11.51 |
ENSMUST00000003501.7
|
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) |
|
| chr12_+_109453455 Show fit | 11.20 |
ENSMUST00000109844.4
ENSMUST00000109842.2 ENSMUST00000109843.1 ENSMUST00000109846.4 ENSMUST00000173539.1 ENSMUST00000109841.2 |
delta-like 1 homolog (Drosophila) |
|
| chr4_+_122995944 Show fit | 10.82 |
ENSMUST00000106252.2
|
v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived (avian) |
|
| chr12_-_112929415 Show fit | 10.77 |
ENSMUST00000075827.3
|
jagged 2 |
|
| chr9_+_106453838 Show fit | 10.30 |
ENSMUST00000024260.6
|
poly(rC) binding protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfdp1_Wt1_Egr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 38.8 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 1.3 | 35.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.7 | 25.5 | GO:0006284 | base-excision repair(GO:0006284) |
| 2.0 | 21.7 | GO:2000980 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.4 | 21.2 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.2 | 20.1 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 5.6 | 16.8 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 1.8 | 16.4 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 2.3 | 16.1 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.4 | 15.7 | GO:1902808 | positive regulation of cell cycle G1/S phase transition(GO:1902808) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 94.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 34.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 32.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.6 | 27.5 | GO:0044298 | cell body membrane(GO:0044298) |
| 0.3 | 25.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 25.0 | GO:0005901 | caveola(GO:0005901) |
| 0.6 | 23.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 1.2 | 21.0 | GO:0070938 | contractile ring(GO:0070938) |
| 2.6 | 20.5 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.3 | 20.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 36.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 34.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 30.7 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.7 | 30.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.3 | 28.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 27.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 21.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 19.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 18.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 56.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 44.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.8 | 39.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.8 | 37.2 | PID ATR PATHWAY | ATR signaling pathway |
| 1.9 | 29.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 29.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 28.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 23.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 20.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 16.7 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 44.4 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.8 | 36.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.6 | 32.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.5 | 30.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.6 | 26.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.3 | 24.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.9 | 23.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 22.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 2.6 | 20.9 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.3 | 18.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |