ISMARA results: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41

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avrg: 12D miR HR13_24

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Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 3.27

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Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Gene Symbol	Gene ID	Gene Info
Tfeb Ensembl NCBI MGI UniProt	ENSMUSG00000023990.12	transcription factor EB
Usf1 Ensembl NCBI MGI UniProt	ENSMUSG00000026641.7	upstream transcription factor 1
Srebf1 Ensembl NCBI MGI UniProt	ENSMUSG00000020538.9	sterol regulatory element binding transcription factor 1
Usf2 Ensembl NCBI MGI UniProt	ENSMUSG00000058239.7	upstream transcription factor 2
Bhlhe41 Ensembl NCBI MGI UniProt	ENSMUSG00000030256.5	basic helix-loop-helix family, member e41
Srebf2 Ensembl NCBI MGI UniProt	ENSMUSG00000022463.7	sterol regulatory element binding factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Bhlhe41	mm10_v2_chr6_-_145865483_145865558	-0.80	3.0e-03	Click!
Srebf2	mm10_v2_chr15_+_82147238_82147275	-0.78	4.8e-03	Click!
Tfeb	mm10_v2_chr17_+_47737030_47737107	-0.77	5.3e-03	Click!
Usf1	mm10_v2_chr1_+_171411343_171411384	-0.77	5.6e-03	Click!
Usf2	mm10_v2_chr7_-_30956742_30956803	-0.74	9.2e-03	Click!
Srebf1	mm10_v2_chr11_-_60220550_60220632	0.51	1.1e-01	Click!

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_13159135 Show fit	14.45	ENSMUST00000033824.6	Lamp1 Ensembl NCBI MGI UniProt Show fit	lysosomal-associated membrane protein 1
chr10_+_41519493 Show fit	6.75	ENSMUST00000019962.8	Cd164 Ensembl NCBI MGI UniProt Show fit	CD164 antigen
chr17_-_26939464 Show fit	6.50	ENSMUST00000025027.8 ENSMUST00000114935.1	Cuta Ensembl NCBI MGI UniProt Show fit	cutA divalent cation tolerance homolog (E. coli)
chr13_-_92131494 Show fit	6.42	ENSMUST00000099326.3 ENSMUST00000146492.1	Rasgrf2 Ensembl NCBI MGI UniProt Show fit	RAS protein-specific guanine nucleotide-releasing factor 2
chr17_+_57062231 Show fit	5.50	ENSMUST00000097299.3 ENSMUST00000169543.1 ENSMUST00000163763.1	Crb3 Ensembl NCBI MGI UniProt Show fit	crumbs homolog 3 (Drosophila)
chr4_+_104766334 Show fit	5.45	ENSMUST00000065072.6	C8b Ensembl NCBI MGI UniProt Show fit	complement component 8, beta polypeptide
chr4_+_104766308 Show fit	5.40	ENSMUST00000031663.3	C8b Ensembl NCBI MGI UniProt Show fit	complement component 8, beta polypeptide
chr11_+_69991061 Show fit	5.23	ENSMUST00000018711.8	Gabarap Ensembl NCBI MGI UniProt Show fit	gamma-aminobutyric acid receptor associated protein
chr11_+_61684419 Show fit	5.01	ENSMUST00000093019.5	Fam83g Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 83, member G
chr14_-_72602945 Show fit	4.74	ENSMUST00000162825.1	Fndc3a Ensembl NCBI MGI UniProt Show fit	fibronectin type III domain containing 3A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.8	14.5	GO:0043323	positive regulation of natural killer cell degranulation(GO:0043323)
0.3	11.2	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
0.7	10.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.4	8.5	GO:0007035	vacuolar acidification(GO:0007035)
0.3	8.3	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.7	7.5	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1	6.9	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1	6.8	GO:0030203	glycosaminoglycan metabolic process(GO:0030203)
1.7	6.7	GO:0070829	heterochromatin maintenance(GO:0070829)
0.6	6.7	GO:0006824	cobalt ion transport(GO:0006824)

Showing 1 to 10 of 429 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	14.5	GO:0044194	cytolytic granule(GO:0044194)
0.1	12.0	GO:0005770	late endosome(GO:0005770)
0.1	11.8	GO:0070160	occluding junction(GO:0070160)
1.1	10.8	GO:0005579	membrane attack complex(GO:0005579)
1.4	7.0	GO:1990037	Lewy body core(GO:1990037)
0.1	7.0	GO:0031901	early endosome membrane(GO:0031901)
0.0	7.0	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.6	6.1	GO:0071141	SMAD protein complex(GO:0071141)
0.2	5.6	GO:0000421	autophagosome membrane(GO:0000421)
0.3	5.3	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Showing 1 to 10 of 166 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	8.5	GO:0019905	syntaxin binding(GO:0019905)
0.4	7.3	GO:0050811	GABA receptor binding(GO:0050811)
0.1	7.3	GO:0019003	GDP binding(GO:0019003)
0.8	6.9	GO:0031419	cobalamin binding(GO:0031419)
2.2	6.7	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1	6.5	GO:0005507	copper ion binding(GO:0005507)
0.1	6.4	GO:0030332	cyclin binding(GO:0030332)
0.3	5.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.9	4.4	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Showing 1 to 10 of 282 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	6.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	5.6	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.2	3.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	3.9	PID LKB1 PATHWAY	LKB1 signaling events
0.1	3.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	2.9	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	2.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	2.6	PID FOXO PATHWAY	FoxO family signaling
0.0	2.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.4	10.0	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	10.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3	8.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2	7.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.6	5.9	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.6	5.5	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3	5.0	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	5.0	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	4.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 93 entries

Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 3.27

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Activity-expression correlation:

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: