Project
avrg: 12D miR HR13_24
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Results for Trp53
Z-value: 2.21
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Transcription factors associated with Trp53
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Trp53 | mm10_v2_chr11_+_69580359_69580382 | 0.82 | 1.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_40755201 Show fit | 3.96 |
ENSMUST00000020576.7
|
cyclin G1 |
|
| chr17_+_29090969 Show fit | 3.69 |
ENSMUST00000119901.1
|
cyclin-dependent kinase inhibitor 1A (P21) |
|
| chr5_-_38480131 Show fit | 1.76 |
ENSMUST00000143758.1
ENSMUST00000067886.5 |
solute carrier family 2 (facilitated glucose transporter), member 9 |
|
| chr1_-_79858627 Show fit | 1.60 |
ENSMUST00000027467.4
|
serine (or cysteine) peptidase inhibitor, clade E, member 2 |
|
| chr15_+_62039216 Show fit | 1.58 |
ENSMUST00000183297.1
|
plasmacytoma variant translocation 1 |
|
| chr15_+_85859689 Show fit | 1.40 |
ENSMUST00000170629.1
|
G two S phase expressed protein 1 |
|
| chr8_-_22185758 Show fit | 1.35 |
ENSMUST00000046916.7
|
cytoskeleton associated protein 2 |
|
| chr2_+_152962485 Show fit | 1.33 |
ENSMUST00000099197.2
ENSMUST00000103155.3 |
tubulin tyrosine ligase-like family, member 9 |
|
| chr15_-_102350692 Show fit | 1.32 |
ENSMUST00000041208.7
|
achalasia, adrenocortical insufficiency, alacrimia |
|
| chr7_+_16309577 Show fit | 1.30 |
ENSMUST00000002152.6
|
BCL2 binding component 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Trp53
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.3 | 3.3 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 0.2 | 3.0 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.7 | 2.1 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
| 0.3 | 1.6 | GO:0061110 | dense core granule biogenesis(GO:0061110) |
| 0.0 | 1.6 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 1.3 | GO:0051220 | cytoplasmic sequestering of protein(GO:0051220) |
| 0.1 | 1.1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.3 | 1.0 | GO:0002540 | leukotriene production involved in inflammatory response(GO:0002540) |
| 0.3 | 1.0 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.7 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 2.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 1.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 1.6 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 1.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 1.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 1.0 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.9 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.7 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.3 | 3.0 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 2.1 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 1.1 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.1 | 1.1 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 1.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 1.0 | GO:0004051 | arachidonate 5-lipoxygenase activity(GO:0004051) |
| 0.2 | 0.9 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.1 | 0.7 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.7 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.4 | 3.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.2 | 3.0 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.3 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 1.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.6 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |