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avrg: 12D miR HR13_24
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Results for Xbp1_Creb3l1
Z-value: 5.61
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Transcription factors associated with Xbp1_Creb3l1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb3l1 | mm10_v2_chr2_-_92024502_92024529 | 0.94 | 1.8e-05 | Click! |
| Xbp1 | mm10_v2_chr11_+_5520652_5520659 | 0.93 | 2.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Xbp1_Creb3l1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.9 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 1.0 | 13.8 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.3 | 12.1 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.8 | 10.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.5 | 8.9 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 8.3 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.7 | 7.4 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.2 | 6.6 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 2.2 | 6.5 | GO:2000845 | negative regulation of glucagon secretion(GO:0070093) positive regulation of testosterone secretion(GO:2000845) |
| 0.3 | 6.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 50.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 15.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.7 | 14.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 12.9 | GO:0016604 | nuclear body(GO:0016604) |
| 0.4 | 9.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.6 | 8.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 1.1 | 5.5 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 4.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.4 | 4.5 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.5 | 4.1 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.7 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.1 | 18.5 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 9.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 9.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 7.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 7.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 6.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.2 | 5.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.2 | 5.0 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 1.2 | 4.8 | GO:0046923 | ER retention sequence binding(GO:0046923) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 5.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 3.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 3.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 2.6 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 2.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 2.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 1.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 14.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.4 | 8.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.4 | 7.9 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.6 | 7.4 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.2 | 4.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 4.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 4.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 3.9 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 2.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |