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avrg: 12D miR HR13_24
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Results for Ybx1_Nfya_Nfyb_Nfyc_Cebpz
Z-value: 9.07
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Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000028639.8 | Y box protein 1 | |
| ENSMUSG00000023994.7 | nuclear transcription factor-Y alpha | |
| ENSMUSG00000020248.12 | nuclear transcription factor-Y beta | |
| ENSMUSG00000032897.11 | nuclear transcription factor-Y gamma | |
| ENSMUSG00000024081.8 | CCAAT/enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ybx1 | mm10_v2_chr4_-_119294520_119294604 | 0.98 | 2.1e-07 | Click! |
| Cebpz | mm10_v2_chr17_-_78937031_78937074 | 0.91 | 9.7e-05 | Click! |
| Nfyc | mm10_v2_chr4_-_120825665_120825707 | 0.90 | 1.8e-04 | Click! |
| Nfya | mm10_v2_chr17_-_48409729_48409906 | 0.87 | 5.4e-04 | Click! |
| Nfyb | mm10_v2_chr10_-_82764088_82764144 | 0.76 | 6.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 52.6 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.7 | 37.1 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.9 | 32.5 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.2 | 30.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 3.5 | 24.2 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 5.3 | 21.3 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
| 6.4 | 19.3 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 1.1 | 18.2 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.9 | 17.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 17.7 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 54.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.8 | 47.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 45.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 43.6 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 38.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 7.6 | 38.1 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.1 | 28.9 | GO:0005813 | centrosome(GO:0005813) |
| 4.4 | 26.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.9 | 22.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 3.1 | 21.7 | GO:0005818 | aster(GO:0005818) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 57.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 45.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 25.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 5.7 | 22.9 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 4.5 | 22.4 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.7 | 21.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 20.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.4 | 19.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 19.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 2.2 | 17.6 | GO:0035174 | histone serine kinase activity(GO:0035174) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 128.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.3 | 52.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.7 | 23.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.8 | 22.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.6 | 21.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 18.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 17.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.9 | 14.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.5 | 13.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.4 | 13.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 87.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 36.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 2.2 | 34.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.3 | 34.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 3.0 | 30.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 1.2 | 29.8 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 1.7 | 21.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.1 | 17.8 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 16.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 15.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |