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Results for LHX3+lhx4

Z-value: 0.95

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Transcription factors associated with LHX3+lhx4

Gene Symbol Gene ID Gene Info
ENSDARG00000003803 LIM homeobox 3
ENSDARG00000039458 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx4dr10_dc_chr8_-_14446883_144468940.949.4e-08Click!
LHX3dr10_dc_chr5_+_71028018_710280450.931.3e-07Click!

Activity profile of LHX3+lhx4 motif

Sorted Z-values of LHX3+lhx4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3+lhx4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_+_34832049 3.31 ENSDART00000100735
ENSDART00000133996
short stature homeobox
chr13_+_24148599 3.19 ENSDART00000058629
actin, alpha 1b, skeletal muscle
chr20_-_22576513 2.81 ENSDART00000103510
platelet-derived growth factor receptor, alpha polypeptide
chr8_-_34077387 2.70 ENSDART00000159208
ENSDART00000040126
ENSDART00000048994
ENSDART00000098822
pre-B-cell leukemia homeobox 3b
chr16_+_23516127 2.62 ENSDART00000004679
ictacalcin
chr4_+_9668755 2.48 ENSDART00000004604
si:dkey-153k10.9
chr20_+_19613133 2.34 ENSDART00000152548
ENSDART00000063696
all-trans retinoic acid-induced differentiation factor
chr17_+_15425559 2.15 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr20_-_3970778 2.15 ENSDART00000178724
ENSDART00000178565
tripartite motif containing 67
chr21_+_25199691 2.13 ENSDART00000168140
ENSDART00000112783
transmembrane protein 45B
chr9_+_36092350 2.11 ENSDART00000005086
ATPase, Na+/K+ transporting, alpha 1b polypeptide
chr16_+_46145286 2.05 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr19_-_5781358 2.03 ENSDART00000082050
zgc:174904
chr5_-_40894631 1.96 ENSDART00000121840
eukaryotic translation elongation factor 2, like 2
chr6_-_16590883 1.95 ENSDART00000153552
nodal modulator
chr14_-_26238386 1.88 ENSDART00000105933
transforming growth factor, beta-induced
chr17_+_38528709 1.87 ENSDART00000123298
StAR-related lipid transfer (START) domain containing 9
chr24_-_1155215 1.80 ENSDART00000177356
integrin, beta 1a
chr14_-_20760787 1.79

chr20_-_48677794 1.79 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr4_-_73485204 1.74 ENSDART00000122898
PHD finger protein 21B
chr1_-_4757890 1.72 ENSDART00000114035
motor neuron and pancreas homeobox 2b
chr17_-_29102320 1.65 ENSDART00000104204
forkhead box G1a
chr1_-_44476084 1.63 ENSDART00000034549
zgc:111983
chr14_+_47326080 1.61 ENSDART00000047525
crystallin, beta A1, like 1
chr19_-_39048324 1.59 ENSDART00000086717
collagen, type XVI, alpha 1
chr23_+_36023748 1.57

chr3_-_23444371 1.53 ENSDART00000087726
insulin-like growth factor 2 mRNA binding protein 1
chr20_-_9107294 1.53 ENSDART00000140792
OMA1 zinc metallopeptidase
chr18_-_43890514 1.50 ENSDART00000087382
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr19_-_23037220 1.50 ENSDART00000090669
plectin a
chr6_-_18891908 1.50 ENSDART00000074327
insulin-like growth factor binding protein 2a
chr6_+_23787804 1.48 ENSDART00000163188
zinc finger protein 648
chr10_-_43924675 1.47 ENSDART00000052307
arrestin domain containing 3b
chr7_+_26357875 1.47 ENSDART00000101044
heat shock factor binding protein 1a
chr9_+_308260 1.46 ENSDART00000163474
SH3 and cysteine rich domain 3
chr15_-_23441268 1.45 ENSDART00000078570
C1q and TNF related 5
chr4_-_15442828 1.43 ENSDART00000157414
plexin A4
chr13_+_29640492 1.42 ENSDART00000160944
paired box 2a
chr7_-_25623974 1.40 ENSDART00000173602
CD99 molecule-like 2
chr11_+_30416115 1.38 ENSDART00000161662
tau tubulin kinase 1a
chr24_-_6048914 1.37 ENSDART00000146830
ENSDART00000021981
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr14_-_17257773 1.36 ENSDART00000082667
fibroblast growth factor receptor-like 1a
chr1_+_21037251 1.36

chr9_-_37940101 1.35 ENSDART00000087663
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr19_+_12995955 1.34 ENSDART00000132892
collagen triple helix repeat containing 1a
chr18_+_21419735 1.34 ENSDART00000144523
N-terminal EF-hand calcium binding protein 2
chr15_+_9351511 1.33 ENSDART00000144381
sarcoglycan, gamma
chr2_+_29729161 1.33 ENSDART00000141666
ENSDARG00000093205
chr22_+_16509286 1.33 ENSDART00000083063
T-cell acute lymphocytic leukemia 1
chr24_-_14447773 1.33

chr1_-_40208544 1.33 ENSDART00000027463
H6 family homeobox 4
chr1_-_40208469 1.32 ENSDART00000027463
H6 family homeobox 4
chr8_+_2428689 1.31 ENSDART00000081325
dynein, light chain, LC8-type 1
chr6_-_14821305 1.31

chr18_+_43041488 1.30

chr5_+_62987426 1.30 ENSDART00000178937
dynamin 1b
chr6_-_8075384 1.30 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr5_-_67233396 1.29 ENSDART00000051833
ENSDART00000124890
GS homeobox 1
chr11_+_7518953 1.29 ENSDART00000171813
adhesion G protein-coupled receptor L2a
chr7_-_39170016 1.27 ENSDART00000161191
ENSDARG00000101872
chr1_-_29919280 1.25 ENSDART00000152175
mitotic spindle organizing protein 1
chr24_+_35899507 1.25 ENSDART00000122408
si:dkeyp-7a3.1
chr19_+_5562107 1.22 ENSDART00000082080
junction plakoglobin b
chr22_+_38220826 1.22 ENSDART00000010537
ceruloplasmin
chr7_+_25052687 1.21 ENSDART00000110347
cytochrome P450, family 26, subfamily b, polypeptide 1
chr21_+_28441951 1.21 ENSDART00000077887
solute carrier family 22 (organic anion transporter), member 6, like
chr2_+_36718808 1.21 ENSDART00000002510
golgi integral membrane protein 4b
chr17_+_25500291 1.20 ENSDART00000041721
crystallin beta-gamma domain containing 1a
chr14_+_2969679 1.19 ENSDART00000044678
ENSDARG00000034011
chr20_-_28739099 1.19 ENSDART00000135513
regulator of G protein signaling 6
chr25_+_5695630 1.18 ENSDART00000161035
chromosome 12 open reading frame 75
chr19_+_44185325 1.16 ENSDART00000063870
ribosomal protein L11
chr20_-_9474672 1.14 ENSDART00000152674
ENSDARG00000033201
chr7_-_24428781 1.12 ENSDART00000052802
calbindin 2b
chr8_+_43334181 1.11 ENSDART00000038566
family with sequence similarity 101, member A
chr13_-_29290894 1.11 ENSDART00000150228
choline O-acetyltransferase a
chr1_-_53403731 1.09 ENSDART00000171722
single-pass membrane protein with aspartate-rich tail 1b
chr1_+_39844690 1.09 ENSDART00000122059
short coiled-coil protein a
chr19_+_20183210 1.09 ENSDART00000164968
homeobox A4a
chr17_+_25463178 1.08 ENSDART00000139451
crystallin beta-gamma domain containing 1a
chr1_-_674449 1.07 ENSDART00000160564
cysteine/tyrosine-rich 1
chr16_+_46435014 1.07 ENSDART00000144000
rapunzel 2
chr15_-_15513719 1.07 ENSDART00000101918
protein interacting with cyclin A1
chr24_-_26165778 1.06 ENSDART00000080113
apolipoprotein Db
chr7_-_47900199 1.06 ENSDART00000174262
metastasis suppressor 1-like b
chr14_-_16791447 1.05 ENSDART00000158002
ENSDARG00000103278
chr16_-_13733759 1.05 ENSDART00000164344
si:dkeyp-69b9.6
chr7_+_24762755 1.04 ENSDART00000170873
sb:cb1058
chr14_-_7774262 1.04 ENSDART00000045109
zgc:92242
chr13_-_29875809 1.03 ENSDART00000049624
wingless-type MMTV integration site family, member 8b
chr16_-_28943421 1.02 ENSDART00000149501
si:dkey-239n17.4
chr11_-_6051096 1.02 ENSDART00000147761
vessel-specific 1
chr23_+_5632124 1.01 ENSDART00000059307
sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase)
chr8_+_23464087 1.01 ENSDART00000026316
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr10_+_13042496 1.00 ENSDART00000158919
lysophosphatidic acid receptor 1
chr12_-_4497094 0.99 ENSDART00000163651
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr15_-_14616083 0.99 ENSDART00000171169
numb homolog (Drosophila)-like
chr21_+_10775209 0.99

chr2_+_21267793 0.98 ENSDART00000099913
phospholipase A2, group IVAa (cytosolic, calcium-dependent)
chr1_-_18809429 0.97 ENSDART00000124260
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr9_-_14137664 0.96 ENSDART00000132747
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr1_-_30801520 0.95 ENSDART00000007770
ladybird homeobox 1b
chr6_+_52350428 0.95 ENSDART00000151612
si:ch211-239j9.1
chr14_+_27936303 0.95 ENSDART00000003293
midline 2
chr5_-_13738619 0.95 ENSDART00000090788
neuropeptide FF receptor 1 like 2
chr25_-_21718782 0.94 ENSDART00000175132
ENSDARG00000051873
chr13_-_9554501 0.94 ENSDART00000139541
ENSDARG00000069828
chr1_-_22160662 0.94 ENSDART00000054386
quinoid dihydropteridine reductase b1
chr9_+_947223 0.93 ENSDART00000159892
dedicator of cytokinesis 9a
chr9_-_51975919 0.93 ENSDART00000006612
T-box, brain, 1b
chr5_-_40894693 0.92 ENSDART00000051081
eukaryotic translation elongation factor 2, like 2
chr20_-_21031504 0.92 ENSDART00000152726
BTB (POZ) domain containing 6b
chr3_-_19218660 0.92 ENSDART00000132987
sphingosine-1-phosphate receptor 5a
chr25_-_5883620 0.92 ENSDART00000136054
sorting nexin 22
chr19_-_27284726 0.91 ENSDART00000089699
proline-rich transmembrane protein 1
chr14_-_4038642 0.91 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr13_+_33151628 0.91 ENSDART00000135200
coiled-coil domain containing 28B
chr10_-_27087472 0.90 ENSDART00000143451
cornichon family AMPA receptor auxiliary protein 2
chr8_-_11512545 0.90 ENSDART00000133932
si:ch211-248e11.2
chr12_-_7902815 0.89 ENSDART00000088100
ankyrin 3b
chr7_+_19243998 0.89 ENSDART00000173766
si:ch211-212k18.8
chr21_+_45802046 0.89 ENSDART00000038657
fatty acid hydroxylase domain containing 2
chr8_-_19166630 0.88

chr19_-_28546417 0.87 ENSDART00000130922
ENSDART00000079114
iroquois homeobox 1b
chr5_+_71028018 0.87 ENSDART00000164893
ENSDART00000159658
ENSDART00000097164
ENSDART00000124939
ENSDART00000171230
LIM homeobox 3
chr14_-_45883839 0.86

chr8_-_17130805 0.86

chr21_-_5692160 0.86 ENSDART00000075137
ENSDART00000151202
cyclin I
chr15_-_18226612 0.86 ENSDART00000012064
PIH1 domain containing 2
chr16_-_28921444 0.86 ENSDART00000078543
synaptotagmin XIb
chr16_-_45211650 0.86 ENSDART00000165186
si:dkey-33i11.9
chr4_+_22759177 0.85 ENSDART00000146272
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
chr20_-_27193158 0.84 ENSDART00000062096
si:dkeyp-55f12.3
chr23_+_36016450 0.84 ENSDART00000103035
homeobox C6a
chr15_-_37949371 0.83 ENSDART00000031418
heat shock cognate 70
chr3_-_60930025 0.82 ENSDART00000055064
parvalbumin 8
chr25_+_13309645 0.81 ENSDART00000010495
zinc and ring finger 1
chr14_-_47083485 0.80 ENSDART00000172512
E74-like factor 2a (ets domain transcription factor)
chr15_-_8333117 0.80 ENSDART00000061351
tumor necrosis factor receptor superfamily, member 19
chr12_-_34621359 0.79

chr21_-_25567978 0.79 ENSDART00000133134
EGF containing fibulin-like extracellular matrix protein 2b
chr4_-_935448 0.79 ENSDART00000171855
single-minded family bHLH transcription factor 1b
chr20_-_54192057 0.77 ENSDART00000023550
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr24_+_24686591 0.77 ENSDART00000080969
tripartite motif containing 55b
chr8_-_12365342 0.76 ENSDART00000113286
PHD finger protein 19
chr7_-_27877036 0.75 ENSDART00000044208
LIM domain only 1
chr7_-_26331734 0.75

chr11_+_15935769 0.74 ENSDART00000158824
chitobiase, di-N-acetyl-
chr5_-_9162684 0.74

chr3_-_43730993 0.72

chr24_-_24306469 0.72 ENSDART00000154149
ENSDARG00000097984
chr13_+_24148474 0.71 ENSDART00000058629
actin, alpha 1b, skeletal muscle
chr10_-_11303185 0.70 ENSDART00000146727
polypyrimidine tract binding protein 3
chr24_+_37692365 0.70

chr16_+_29060022 0.70 ENSDART00000088023
gon-4-like (C. elegans)
chr6_-_43679553 0.70 ENSDART00000150128
forkhead box P1b
chr2_-_49114158 0.69

chr7_+_21006803 0.68 ENSDART00000052942
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr20_-_2936289 0.68 ENSDART00000104667
cyclin-dependent kinase 19
chr24_-_24001766 0.68 ENSDART00000173052
ENSDART00000173220
MAP7 domain containing 2b
chr2_+_1825714 0.67 ENSDART00000148624
HIG1 hypoxia inducible domain family, member 1A
chr1_+_18842158 0.67 ENSDART00000103089
ENSDARG00000070320
chr4_+_5246465 0.67 ENSDART00000137966
coiled-coil domain containing 167
chr2_+_29507819 0.66

chr14_-_47129958 0.65 ENSDART00000172166
NADH:ubiquinone oxidoreductase subunit C1
chr3_+_50511676 0.65 ENSDART00000102202
phosphatidic acid phosphatase type 2D
chr8_-_12365285 0.64 ENSDART00000142150
PHD finger protein 19
chr8_+_31812204 0.64 ENSDART00000077053
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr12_-_28248133 0.64 ENSDART00000016283
proteasome 26S subunit, non-ATPase 11b
chr19_-_4079427 0.64 ENSDART00000170325
MAP7 domain containing 1b
chr3_+_32234028 0.64 ENSDART00000155967
adaptor-related protein complex 2, alpha 1 subunit
chr14_-_1342450 0.64 ENSDART00000060417
centrin 4
chr1_+_40795366 0.63 ENSDART00000146310
deltex 4, E3 ubiquitin ligase
chr16_-_13734068 0.63 ENSDART00000164344
si:dkeyp-69b9.6
chr5_-_37494209 0.63 ENSDART00000084890
si:ch211-284e13.4
chr19_-_39048402 0.63 ENSDART00000086717
collagen, type XVI, alpha 1
KN150123v1_-_37214 0.62

chr20_-_52526843 0.62 ENSDART00000132941
si:ch1073-287p18.1
chr24_+_24316486 0.62 ENSDART00000147658
basic helix-loop-helix family, member e22
chr4_+_70768190 0.61

KN150474v1_-_163952 0.60

chr6_+_28215039 0.60 ENSDART00000104394
smx5
chr13_+_32609784 0.60 ENSDART00000160138
sine oculis binding protein homolog (Drosophila) a
chr20_+_36098607 0.59 ENSDART00000021456
opsin 5
chr7_+_19300351 0.59 ENSDART00000169060
si:ch211-212k18.5
chr16_-_26083913 0.59 ENSDART00000166681
ferric-chelate reductase 1-like
chr17_-_12812747 0.58 ENSDART00000022874
ENSDART00000046025
proteasome subunit alpha 6a
chr15_-_21003820 0.58 ENSDART00000152371
ubiquitin specific peptidase 2a
chr16_-_21334269 0.58 ENSDART00000145837
si:dkey-271j15.3
chr2_+_7054686 0.57 ENSDART00000057385
nitric oxide synthase 1 (neuronal) adaptor protein b
chr25_+_23326630 0.57

chr21_+_27241416 0.57

chr20_+_7596461 0.56 ENSDART00000127975
ENSDART00000132481
ENSDART00000144551
biogenesis of lysosomal organelles complex-1, subunit 2
chr15_+_23615727 0.56 ENSDART00000152720
microtubule affinity regulating kinase 4
chr16_-_48189682 0.55

chr14_-_31514534 0.54 ENSDART00000003345
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_-_52792076 0.52 ENSDART00000097716
zgc:136336
chr3_-_32205873 0.52 ENSDART00000156918
si:dkey-16p21.8
chr25_+_23326562 0.52

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.6 2.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.5 1.5 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.5 2.3 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.4 1.2 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.4 1.5 GO:0040014 regulation of multicellular organism growth(GO:0040014)
0.4 1.1 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.4 1.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 1.5 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.3 1.0 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.3 1.0 GO:0002706 regulation of lymphocyte mediated immunity(GO:0002706)
0.3 2.8 GO:0003315 heart rudiment formation(GO:0003315)
0.3 1.8 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.3 1.4 GO:0021588 cerebellum formation(GO:0021588)
0.3 0.8 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.3 1.3 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 1.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 0.7 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 1.0 GO:0042698 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698) inflammatory response to wounding(GO:0090594)
0.2 1.2 GO:0046677 response to antibiotic(GO:0046677)
0.2 1.3 GO:0050975 sensory perception of touch(GO:0050975)
0.2 0.7 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.2 1.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274) acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.2 1.4 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.2 2.6 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.2 1.3 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 1.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 2.0 GO:0043584 nose development(GO:0043584)
0.2 0.5 GO:0008347 glial cell migration(GO:0008347)
0.2 0.5 GO:0009713 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.2 0.3 GO:0030279 negative regulation of ossification(GO:0030279)
0.2 0.6 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.2 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 1.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 1.1 GO:0050482 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2 0.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.6 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.1 0.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 1.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 1.0 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.1 1.4 GO:0021592 fourth ventricle development(GO:0021592)
0.1 0.4 GO:0042590 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.9 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 2.1 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.2 GO:0098900 regulation of action potential(GO:0098900)
0.1 3.3 GO:0030282 bone mineralization(GO:0030282)
0.1 1.8 GO:1903672 positive regulation of sprouting angiogenesis(GO:1903672)
0.1 1.2 GO:0006826 iron ion transport(GO:0006826)
0.1 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.4 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 1.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.3 GO:0032475 otolith formation(GO:0032475)
0.1 2.2 GO:0015696 ammonium transport(GO:0015696)
0.1 0.6 GO:0002159 desmosome assembly(GO:0002159)
0.1 1.1 GO:0097178 ruffle assembly(GO:0097178)
0.1 0.8 GO:0042026 protein refolding(GO:0042026)
0.1 1.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.6 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.1 0.2 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 5.0 GO:0048747 muscle fiber development(GO:0048747)
0.1 0.3 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.3 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 3.0 GO:0006414 translational elongation(GO:0006414)
0.1 0.4 GO:0060088 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.6 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 1.3 GO:0000302 response to reactive oxygen species(GO:0000302)
0.0 2.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 1.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.7 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.3 GO:0001973 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 2.3 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 1.4 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 1.6 GO:0007601 visual perception(GO:0007601)
0.0 0.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 1.4 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.0 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.5 GO:0048634 regulation of muscle organ development(GO:0048634)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.1 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.0 0.2 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 1.8 GO:0048738 cardiac muscle tissue development(GO:0048738)
0.0 2.2 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.4 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.6 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.6 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 1.3 GO:0003407 neural retina development(GO:0003407)
0.0 1.5 GO:0060026 convergent extension(GO:0060026)
0.0 0.2 GO:0009409 response to cold(GO:0009409)
0.0 0.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 3.9 GO:0005869 dynactin complex(GO:0005869)
0.3 1.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 1.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 1.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 1.1 GO:1990246 uniplex complex(GO:1990246)
0.2 0.9 GO:0097255 R2TP complex(GO:0097255)
0.1 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.5 GO:0030315 T-tubule(GO:0030315)
0.1 2.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.2 GO:0043209 myelin sheath(GO:0043209)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.1 GO:0043195 terminal bouton(GO:0043195)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 2.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 4.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 2.1 GO:0030424 axon(GO:0030424)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 3.4 GO:0043235 receptor complex(GO:0043235)
0.0 0.8 GO:0005814 centriole(GO:0005814)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 5.9 GO:0005615 extracellular space(GO:0005615)
0.0 1.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.7 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.3 1.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 1.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 0.7 GO:0004568 chitinase activity(GO:0004568)
0.2 1.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.9 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.2 2.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 2.1 GO:0005504 fatty acid binding(GO:0005504)
0.2 1.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.5 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 1.5 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.1 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.5 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 1.9 GO:0005518 collagen binding(GO:0005518)
0.1 1.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.6 GO:0016918 retinal binding(GO:0016918)
0.1 1.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.6 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.1 3.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0008665 tRNA 2'-phosphotransferase activity(GO:0000215) 2'-phosphotransferase activity(GO:0008665)
0.1 0.4 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 0.9 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 2.8 GO:0019838 growth factor binding(GO:0019838)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.0 GO:0016208 AMP binding(GO:0016208)
0.0 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0008009 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.0 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0070042 rRNA (uridine-N3-)-methyltransferase activity(GO:0070042)
0.0 3.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.8 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.9 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 17.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.2 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.8 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 3.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 1.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 1.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.6 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.8 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 2.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.4 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways