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Results for MAZ
Z-value: 6.68
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Transcription factors associated with MAZ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ENSDARG00000063555 | dr10_dc_chr12_-_3741925_3741966 | 0.90 | 2.0e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_44330405 Show fit | 25.35 |
ENSDART00000111246
|
cell adhesion molecule 3 |
|
| chr3_-_32202533 Show fit | 21.91 |
ENSDART00000155757
|
si:dkey-16p21.8 |
|
| chr7_-_57796486 Show fit | 16.40 |
ENSDART00000043984
|
ankyrin 2b, neuronal |
|
| chr7_-_60525749 Show fit | 14.89 |
ENSDART00000136999
|
pyruvate carboxylase b |
|
| chr25_+_31769985 Show fit | 14.36 |
|
|
|
| chr19_+_31046291 Show fit | 14.03 |
ENSDART00000052124
|
family with sequence similarity 49, member A-like |
|
| chr7_+_25758469 Show fit | 13.95 |
ENSDART00000101126
|
arachidonate 12-lipoxygenase |
|
| chr7_+_39130411 Show fit | 13.50 |
ENSDART00000144750
|
troponin I type 2b (skeletal, fast), tandem duplicate 1 |
|
| chr12_-_26760324 Show fit | 13.40 |
ENSDART00000047724
|
zinc finger E-box binding homeobox 1b |
|
| chr8_-_11191783 Show fit | 13.27 |
ENSDART00000131171
|
unc-45 myosin chaperone B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 26.6 | GO:0051492 | regulation of stress fiber assembly(GO:0051492) |
| 0.8 | 24.5 | GO:0050772 | positive regulation of axonogenesis(GO:0050772) |
| 2.3 | 22.7 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 2.0 | 22.2 | GO:0006337 | nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986) |
| 1.2 | 21.9 | GO:0006825 | copper ion transport(GO:0006825) |
| 4.3 | 21.3 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.9 | 20.4 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 1.5 | 17.8 | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) |
| 0.2 | 17.2 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
| 0.8 | 16.9 | GO:0030199 | collagen fibril organization(GO:0030199) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 77.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 70.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 64.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 31.1 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 27.8 | GO:0030054 | cell junction(GO:0030054) |
| 0.1 | 25.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.5 | 22.3 | GO:0042383 | sarcolemma(GO:0042383) |
| 1.4 | 22.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 22.0 | GO:0005576 | extracellular region(GO:0005576) |
| 0.5 | 21.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 90.7 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 65.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 54.9 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.4 | 48.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 24.9 | GO:1990837 | sequence-specific double-stranded DNA binding(GO:1990837) |
| 0.3 | 23.4 | GO:0015293 | symporter activity(GO:0015293) |
| 2.4 | 21.9 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 21.9 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 21.5 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 1.2 | 18.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 19.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 16.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 3.3 | 9.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.3 | 9.5 | PID ATM PATHWAY | ATM pathway |
| 0.8 | 9.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 9.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.5 | 8.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 8.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 7.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.3 | 13.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 1.1 | 13.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.1 | 11.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.5 | 11.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 2.0 | 9.9 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 1.4 | 9.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.8 | 9.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 1.1 | 9.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.3 | 8.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |