ISMARA results: atf4b

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Results for atf4b

Z-value: 0.96

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Transcription factors associated with atf4b

Gene Symbol	Gene ID	Gene Info
atf4b NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000038141	activating transcription factor 4b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf4b	dr10_dc_chr3_+_24067430_24067435	-0.86	2.0e-05	Click!

Activity profile of atf4b motif

Sorted Z-values of atf4b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4b

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Promoter	Score	Transcript	Gene	Gene Info
chr20_+_37891739 Show fit	4.62	ENSDART00000022060	atf3 NCBI UniProt ZFIN ENSEMBL Google Show fit	activating transcription factor 3
chr20_+_37891795 Show fit	3.55	ENSDART00000022060	atf3 NCBI UniProt ZFIN ENSEMBL Google Show fit	activating transcription factor 3
chr12_+_30673985 Show fit	2.87	ENSDART00000160422	aldh18a1 NCBI UniProt ZFIN ENSEMBL Google Show fit	aldehyde dehydrogenase 18 family, member A1
chr14_-_7437682 Show fit	2.43	ENSDART00000172215	si:ch211-39i2.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-39i2.2
chr12_+_17032829 Show fit	2.33	ENSDART00000028003	ankrd22 NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin repeat domain 22
chr18_+_17611571 Show fit	2.23	ENSDART00000151850	herpud1 NCBI UniProt ZFIN ENSEMBL Google Show fit	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_+_43745687 Show fit	2.22	ENSDART00000102384	sesn2 NCBI UniProt ZFIN ENSEMBL Google Show fit	sestrin 2
chr19_+_43745546 Show fit	2.22	ENSDART00000145846	sesn2 NCBI UniProt ZFIN ENSEMBL Google Show fit	sestrin 2
chr18_+_17611931 Show fit	2.10	ENSDART00000141465	herpud1 NCBI UniProt ZFIN ENSEMBL Google Show fit	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr12_+_17032997 Show fit	2.05	ENSDART00000028003	ankrd22 NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin repeat domain 22

Showing 1 to 10 of 121 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.2	GO:0009615	response to virus(GO:0009615)
1.9	7.5	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235) negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.9	7.0	GO:0043201	response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.5	2.7	GO:0010922	positive regulation of phosphatase activity(GO:0010922) positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.4	2.6	GO:0000012	single strand break repair(GO:0000012)
0.6	2.2	GO:0045903	positive regulation of translational fidelity(GO:0045903)
0.4	2.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	2.0	GO:0045879	negative regulation of smoothened signaling pathway(GO:0045879)
0.4	1.8	GO:0055129	proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1	1.7	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)

Showing 1 to 10 of 37 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.5	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.9	7.0	GO:0061700	GATOR2 complex(GO:0061700)
0.1	2.7	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.4	2.2	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	1.5	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0	1.5	GO:0005802	trans-Golgi network(GO:0005802)
0.0	1.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	1.3	GO:0005769	early endosome(GO:0005769)
0.0	1.2	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	1.0	GO:0005680	anaphase-promoting complex(GO:0005680)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.5	GO:0044325	ion channel binding(GO:0044325)
0.9	7.0	GO:0070728	leucine binding(GO:0070728)
0.0	3.1	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.1	2.9	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0	2.7	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.7	2.2	GO:0004617	phosphoglycerate dehydrogenase activity(GO:0004617)
0.0	2.0	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	1.9	GO:0004697	protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0	1.7	GO:0000049	tRNA binding(GO:0000049)
0.1	1.6	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	2.7	PID BMP PATHWAY	BMP receptor signaling
0.0	2.0	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	1.6	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	1.2	PID CMYB PATHWAY	C-MYB transcription factor network

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	13.9	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.3	3.7	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	2.7	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	2.2	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	2.0	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	1.6	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	1.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4	0.8	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors

Showing 1 to 10 of 11 entries

Results for atf4b

Z-value: 0.96

Motif logo

Transcription factors associated with atf4b

Activity-expression correlation:

Activity profile of atf4b motif

Sorted Z-values of atf4b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4b

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: