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Results for atoh1a+atoh1b+atoh1c

Z-value: 0.81

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Transcription factors associated with atoh1a+atoh1b+atoh1c

Gene Symbol Gene ID Gene Info
atoh1c
ENSDARG00000039602 atonal bHLH transcription factor 1c
atoh1a
ENSDARG00000055294 atonal bHLH transcription factor 1a
atoh1b
ENSDARG00000099564 atonal bHLH transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atoh1adr10_dc_chr8_+_29584750_295847570.458.2e-02Click!
atoh1bdr10_dc_chrUn_KN150642v1_+_9419_94540.292.8e-01Click!

Activity profile of atoh1a+atoh1b+atoh1c motif

Sorted Z-values of atoh1a+atoh1b+atoh1c motif

Network of associatons between targets according to the STRING database.

First level regulatory network of atoh1a+atoh1b+atoh1c

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_27346176 1.15 ENSDART00000005682
actn3a
actinin alpha 3a
chr15_-_23711689 1.03 ENSDART00000128644
ckmb
creatine kinase, muscle b
chr9_-_7695437 0.83 ENSDART00000102715
tuba8l3
tubulin, alpha 8 like 3
chr6_-_9964616 0.71

chr17_+_27383737 0.69 ENSDART00000156756
FP017274.1
ENSDARG00000097369
chr18_-_6494014 0.66 ENSDART00000062423
tnni1c
troponin I, skeletal, slow c
chr9_-_23081250 0.66

chr9_-_49834232 0.60

chr25_+_7391458 0.59 ENSDART00000042928
fuk
fucokinase
chr10_-_43826919 0.59 ENSDART00000039551
ENSDART00000160786
ENSDART00000099134
mef2ca
myocyte enhancer factor 2ca
chr23_-_18131105 0.59 ENSDART00000173102
zgc:92287
zgc:92287
chr24_+_7607915 0.58 ENSDART00000124409
cavin1b
caveolae associated protein 1b
chr8_-_6899611 0.58 ENSDART00000139545
wdr13
WD repeat domain 13
chr8_-_22265875 0.57 ENSDART00000134033
si:ch211-147a11.3
si:ch211-147a11.3
chr20_+_34248780 0.56 ENSDART00000152870
arpc5b
actin related protein 2/3 complex, subunit 5B
chr23_-_18131209 0.55 ENSDART00000173102
zgc:92287
zgc:92287
chr22_+_34738389 0.55 ENSDART00000154372
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr10_-_38206238 0.55 ENSDART00000174882
FP016248.1
ENSDARG00000107804
chr2_+_2895642 0.54 ENSDART00000032459
aqp1a.1
aquaporin 1a (Colton blood group), tandem duplicate 1
chr18_+_30391910 0.53 ENSDART00000158871
gse1
Gse1 coiled-coil protein
chr8_+_7340538 0.53 ENSDART00000121708
pcsk1nl
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr1_+_51189343 0.52 ENSDART00000150757
BX548032.3
ENSDARG00000096092
chr5_-_47656197 0.50

chr5_+_29327479 0.50

chr9_+_14052160 0.49 ENSDART00000124267
si:ch211-67e16.4
si:ch211-67e16.4
chr21_-_23710216 0.49 ENSDART00000132570
ncam1a
neural cell adhesion molecule 1a
chr8_+_48106836 0.49 ENSDART00000138717
si:ch211-263k4.2
si:ch211-263k4.2
chr18_+_36825511 0.49 ENSDART00000098958
ttc9b
tetratricopeptide repeat domain 9B
chr10_-_23939618 0.49

chr8_-_14113377 0.49 ENSDART00000090427
si:dkey-6n6.1
si:dkey-6n6.1
chr18_+_23198330 0.48 ENSDART00000143977
mef2aa
myocyte enhancer factor 2aa
chr24_-_23639458 0.48 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr6_+_46307828 0.48 ENSDART00000154817
si:dkeyp-67f1.1
si:dkeyp-67f1.1
chr11_+_6893104 0.47 ENSDART00000144006
crtc1b
CREB regulated transcription coactivator 1b
chr5_-_41672394 0.47 ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr13_-_36265504 0.47 ENSDART00000140243
actn1
actinin, alpha 1
chr3_+_32657833 0.46 ENSDART00000171895
tbc1d10b
TBC1 domain family, member 10b
chr24_+_24924379 0.46 ENSDART00000115165
amer2
APC membrane recruitment protein 2
chr19_-_34328673 0.45 ENSDART00000164563
elmo1
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
KN149932v1_+_27584 0.45

chr12_+_16845837 0.45 ENSDART00000138174
slc16a12b
solute carrier family 16, member 12b
chr3_+_40667131 0.45 ENSDART00000033713
arpc1b
actin related protein 2/3 complex, subunit 1B
chr1_-_28241500 0.45 ENSDART00000019770
gpm6ba
glycoprotein M6Ba
chr19_+_1743359 0.45 ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr1_-_15814788 0.45 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr23_+_29981525 0.44 ENSDART00000035755
dvl1a
dishevelled segment polarity protein 1a
chr9_-_44493074 0.44 ENSDART00000167685
neurod1
neuronal differentiation 1
chr3_-_23466232 0.43 ENSDART00000156897
ube2z
ubiquitin-conjugating enzyme E2Z
chr5_-_51172369 0.43 ENSDART00000164267
ENSDART00000157866
homer1b
homer scaffolding protein 1b
chr25_-_20160885 0.43 ENSDART00000160700
dnm1l
dynamin 1-like
chr2_-_44402486 0.42 ENSDART00000011188
ENSDART00000093298
atp1a2a
ATPase, Na+/K+ transporting, alpha 2a polypeptide
chr11_-_25803101 0.42 ENSDART00000088888
kaznb
kazrin, periplakin interacting protein b
chr23_+_35964754 0.42 ENSDART00000103147
hoxc12a
homeobox C12a
chr15_+_9351511 0.42 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr21_+_9483423 0.41 ENSDART00000162834
mapk10
mitogen-activated protein kinase 10
chr11_-_32461160 0.41 ENSDART00000155592
pcdh17
protocadherin 17
chr2_-_42279180 0.41 ENSDART00000047055
trim55a
tripartite motif containing 55a
chr10_+_34377959 0.41

chr2_-_21512403 0.40 ENSDART00000135417
bmi1b
bmi1 polycomb ring finger oncogene 1b
chr10_-_9123386 0.40 ENSDART00000149493
mocs2
molybdenum cofactor synthesis 2
chr5_+_29327363 0.40

chr20_+_6783810 0.40 ENSDART00000169966
igfbp3
insulin-like growth factor binding protein 3
chr5_+_37254520 0.40 ENSDART00000051222
ins
preproinsulin
chr10_+_15450466 0.40 ENSDART00000003839
nln
neurolysin (metallopeptidase M3 family)
chr16_+_3090170 0.39 ENSDART00000110395
limd1a
LIM domains containing 1a
chr10_+_15819127 0.39 ENSDART00000140511
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr21_-_19789339 0.38

chr2_+_32033176 0.38 ENSDART00000135040
mycb
MYC proto-oncogene, bHLH transcription factor b
chr21_+_5868923 0.38 ENSDART00000098499
dck
deoxycytidine kinase
chr24_-_32750010 0.38 ENSDART00000038364
ca2
carbonic anhydrase II
chr10_-_38206060 0.38 ENSDART00000174882
FP016248.1
ENSDARG00000107804
chr9_+_25285612 0.38 ENSDART00000135074
lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr7_+_24617687 0.38 ENSDART00000173994
mark2b
MAP/microtubule affinity-regulating kinase 2b
chr15_-_8541318 0.38 ENSDART00000140213
npas1
neuronal PAS domain protein 1
chr14_-_36523075 0.38 ENSDART00000109293
rnf130
ring finger protein 130
chr9_+_23854967 0.37 ENSDART00000060905
gypc
glycophorin C (Gerbich blood group)
chr3_-_27944852 0.37 ENSDART00000122037
rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_+_7014241 0.37 ENSDART00000016607
rgs5b
regulator of G protein signaling 5b
chr24_-_18540597 0.37 ENSDART00000176165
zgc:66014
zgc:66014
chr6_-_9329917 0.37 ENSDART00000151470
map3k2
mitogen-activated protein kinase kinase kinase 2
chr1_-_24297477 0.36

chr6_-_35049344 0.36 ENSDART00000168256
ddr2a
discoidin domain receptor tyrosine kinase 2a
chr16_+_5625301 0.36

chr1_+_21244242 0.36 ENSDART00000087729
kdm4c
lysine (K)-specific demethylase 4C
chr8_-_17130805 0.35

chr10_-_17383380 0.35

chr10_-_37098396 0.35 ENSDART00000155277
BX323076.2
ENSDARG00000097288
chr8_-_18547147 0.35 ENSDART00000123917
ENSDART00000063518
tmem47
transmembrane protein 47
chr11_+_41802482 0.35 ENSDART00000173022
camta1
calmodulin binding transcription activator 1
chr10_+_15819085 0.35 ENSDART00000114483
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr7_-_71929355 0.35

chr10_-_38206132 0.35 ENSDART00000174882
FP016248.1
ENSDARG00000107804
chr25_+_29873412 0.35 ENSDART00000067056
ticrr
TopBP1-interacting, checkpoint, and replication regulator
chr16_-_10404109 0.35

chr22_+_16282153 0.35 ENSDART00000162685
ENSDART00000105678
lrrc39
leucine rich repeat containing 39
chr5_+_29327447 0.34

chr13_+_28723589 0.34

chr18_+_8943793 0.34 ENSDART00000144247
si:dkey-5i3.5
si:dkey-5i3.5
chr2_-_44402452 0.34 ENSDART00000011188
ENSDART00000093298
atp1a2a
ATPase, Na+/K+ transporting, alpha 2a polypeptide
chr12_+_5154886 0.34 ENSDART00000163897
lgi1b
leucine-rich, glioma inactivated 1b
chr2_+_32033028 0.33 ENSDART00000005143
mycb
MYC proto-oncogene, bHLH transcription factor b
chr18_-_3244618 0.33 ENSDART00000161520
gdpd4a
glycerophosphodiester phosphodiesterase domain containing 4a
chr8_+_29733109 0.33 ENSDART00000020621
mapk4
mitogen-activated protein kinase 4
chr10_-_17383466 0.33

chr3_-_15889742 0.33 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr23_+_43284714 0.33

chr6_-_6835861 0.33 ENSDART00000053304
si:ch211-114n24.6
si:ch211-114n24.6
chr7_-_55406347 0.32 ENSDART00000021009
cbfa2t3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr5_-_21520111 0.32

chr3_-_32471212 0.32 ENSDART00000150997
si:ch73-248e21.7
si:ch73-248e21.7
chr22_+_26543146 0.32

chr14_-_23440160 0.31 ENSDART00000005842
fgf1a
fibroblast growth factor 1a
chr17_+_8874210 0.31

chr16_+_5625552 0.31

chr17_-_15659244 0.31 ENSDART00000142972
manea
mannosidase, endo-alpha
chr5_+_37144384 0.31 ENSDART00000148766
dpf2
D4, zinc and double PHD fingers family 2
chr22_-_10367866 0.31 ENSDART00000142886
nisch
nischarin
chr7_+_40972616 0.30 ENSDART00000173814
scrib
scribbled planar cell polarity protein
chr4_+_17550101 0.30 ENSDART00000013313
itfg2
integrin alpha FG-GAP repeat containing 2
chr20_-_39371023 0.30 ENSDART00000127173
clu
clusterin
chr17_-_7990960 0.30

chr18_-_47026460 0.30 ENSDART00000108574
gramd1bb
GRAM domain containing 1Bb
chr18_+_29166912 0.30 ENSDART00000089031
ppfibp2a
PTPRF interacting protein, binding protein 2a (liprin beta 2)
chr18_-_12889296 0.30 ENSDART00000130343
parp12a
poly (ADP-ribose) polymerase family, member 12a
chr10_-_13220838 0.30 ENSDART00000160265
musk
muscle, skeletal, receptor tyrosine kinase
chr9_+_33177527 0.30 ENSDART00000174533
vangl1
VANGL planar cell polarity protein 1
chr14_+_2969679 0.30 ENSDART00000044678
ENSDARG00000034011
ENSDARG00000034011
chr7_-_19116999 0.29 ENSDART00000165680
ntn4
netrin 4
chr5_+_43365449 0.29 ENSDART00000113502
TMEM8B
si:dkey-84j12.1
chr2_-_17443642 0.29 ENSDART00000136207
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr25_-_18850809 0.29 ENSDART00000091549
nt5dc3
5'-nucleotidase domain containing 3
chr7_-_68629353 0.29

chr3_-_31713951 0.29 ENSDART00000157028
map3k3
mitogen-activated protein kinase kinase kinase 3
chr20_+_2443682 0.29 ENSDART00000131642
akap7
A kinase (PRKA) anchor protein 7
chr10_-_28474085 0.29

chr1_+_58029993 0.28

chr13_-_36265476 0.28 ENSDART00000133740
ENSDART00000100217
actn1
actinin, alpha 1
chr15_-_7622212 0.28 ENSDART00000165898
gbe1b
glucan (1,4-alpha-), branching enzyme 1b
chr5_-_33169062 0.28 ENSDART00000133504
dab2ipb
DAB2 interacting protein b
chr4_-_4825948 0.27 ENSDART00000141539
coa6
cytochrome c oxidase assembly factor 6
chr24_+_7608106 0.27 ENSDART00000082467
cavin1b
caveolae associated protein 1b
chr7_+_72128846 0.27 ENSDART00000123887
MAPK8IP1 (1 of many)
mitogen-activated protein kinase 8 interacting protein 1
chr25_-_28932291 0.27 ENSDART00000073488
CU469568.1
ENSDARG00000051805
chr1_-_44942047 0.27 ENSDART00000044057
sept3
septin 3
chr14_-_24304373 0.27

chr8_+_52633069 0.26 ENSDART00000162953
cyr61l2
cysteine-rich, angiogenic inducer, 61 like 2
chr19_-_41482388 0.26 ENSDART00000111982
sgce
sarcoglycan, epsilon
chr20_-_26102193 0.26 ENSDART00000136518
capn3b
calpain 3b
chr6_+_23835205 0.26 ENSDART00000162993
gadd45ab
growth arrest and DNA-damage-inducible, alpha, b
chr21_-_21336603 0.25 ENSDART00000079629
ppm1nb
protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative)
chr24_+_7607852 0.25 ENSDART00000124409
cavin1b
caveolae associated protein 1b
chr13_+_25298383 0.25

chr17_-_37040694 0.25 ENSDART00000126823
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr5_+_3965645 0.25 ENSDART00000100061
prdx4
peroxiredoxin 4
chr13_+_51154848 0.25 ENSDART00000163847
nkx6.2
NK6 homeobox 2
chr17_+_26593564 0.25 ENSDART00000159811
ttc7b
tetratricopeptide repeat domain 7B
chr23_+_34103987 0.25 ENSDART00000175235
sars
seryl-tRNA synthetase
chr7_+_28862183 0.25 ENSDART00000052346
gnao1b
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr20_-_26102273 0.24 ENSDART00000063177
capn3b
calpain 3b
chr1_+_9999665 0.24 ENSDART00000054879
ENSDARG00000037679
ENSDARG00000037679
chr23_-_1008307 0.24 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr16_+_21122024 0.24

chr7_+_6517248 0.24 ENSDART00000102681
pnp5a
purine nucleoside phosphorylase 5a
chr12_-_14964315 0.24 ENSDART00000141909
pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
chr14_-_136402 0.24

chr10_-_8764361 0.24

chr6_-_12060971 0.24 ENSDART00000155685
pkp4
plakophilin 4
chr20_+_51918693 0.24 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr23_+_39803084 0.24 ENSDART00000113893
tmco4
transmembrane and coiled-coil domains 4
chr1_-_40208469 0.24 ENSDART00000027463
hmx4
H6 family homeobox 4
chr2_-_21512154 0.24 ENSDART00000135417
bmi1b
bmi1 polycomb ring finger oncogene 1b
chr22_+_16279764 0.23

chr2_+_13779498 0.23 ENSDART00000149309
cfap57
cilia and flagella associated protein 57
chr5_+_27560610 0.23 ENSDART00000051516
tacr1a
tachykinin receptor 1a
chr10_-_34927807 0.23 ENSDART00000138755
dclk1a
doublecortin-like kinase 1a
chr8_-_27667972 0.23 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr16_-_33976031 0.23 ENSDART00000110743
dnali1
dynein, axonemal, light intermediate chain 1
chr16_-_22397159 0.23

chr10_+_21796176 0.22 ENSDART00000128215
CR774179.1
ENSDARG00000086969
chr23_-_8797997 0.22 ENSDART00000014222
tcea2
transcription elongation factor A (SII), 2
chr2_+_30266427 0.22 ENSDART00000135171
tmem70
transmembrane protein 70
chr13_+_24148390 0.22 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr18_-_12889369 0.22 ENSDART00000130343
parp12a
poly (ADP-ribose) polymerase family, member 12a
chr2_+_39142628 0.22 ENSDART00000179419
clstn2
calsyntenin 2
chr16_+_46327528 0.22 ENSDART00000040769
nr2f5
nuclear receptor subfamily 2, group F, member 5
chr24_+_38267919 0.22 ENSDART00000152019
si:ch211-234p6.5
si:ch211-234p6.5
chr17_+_44896438 0.22 ENSDART00000133103
coq6
coenzyme Q6 monooxygenase
chr19_+_24334831 0.22 ENSDART00000090200
snapin
SNAP-associated protein
chr8_+_26210913 0.22 ENSDART00000155529
wdr6
WD repeat domain 6
chr5_+_56649893 0.21 ENSDART00000036331
atp6v1g1
ATPase, H+ transporting, lysosomal, V1 subunit G1
chr18_+_25016753 0.21 ENSDART00000099476
fam174b
family with sequence similarity 174, member B
chr1_+_2074153 0.21 ENSDART00000058877
rap2ab
RAP2A, member of RAS oncogene family b
chr21_-_32449627 0.21

chr10_+_29425917 0.21

chr5_+_3172101 0.21 ENSDART00000080486
ywhag1
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr5_-_40133824 0.21 ENSDART00000010896
isl1
ISL LIM homeobox 1
chr7_-_26653672 0.21 ENSDART00000124363
alx4a
ALX homeobox 4a
chr5_-_52357382 0.21 ENSDART00000157978
mrps30
mitochondrial ribosomal protein S30
chr3_+_48362748 0.21 ENSDART00000157199
mkl2b
MKL/myocardin-like 2b
chr9_+_14052296 0.20 ENSDART00000124267
si:ch211-67e16.4
si:ch211-67e16.4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0015670 carbon dioxide transport(GO:0015670)
0.3 0.8 GO:0010084 specification of organ axis polarity(GO:0010084)
0.2 0.6 GO:1990092 calcium-dependent self proteolysis(GO:1990092)
0.2 1.1 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.4 GO:0001504 neurotransmitter uptake(GO:0001504) regulation of neurotransmitter uptake(GO:0051580) neurotransmitter reuptake(GO:0098810)
0.1 0.4 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 0.4 GO:0030858 positive regulation of epithelial cell differentiation(GO:0030858)
0.1 1.0 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.4 GO:0002686 negative regulation of leukocyte migration(GO:0002686)
0.1 2.1 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.3 GO:0072171 ureteric bud development(GO:0001657) branching involved in ureteric bud morphogenesis(GO:0001658) mesonephros development(GO:0001823) positive regulation of steroid metabolic process(GO:0045940) regulation of steroid biosynthetic process(GO:0050810) ureteric bud morphogenesis(GO:0060675) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) mesonephric tubule morphogenesis(GO:0072171)
0.1 0.5 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.3 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.1 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.4 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 0.4 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.2 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.3 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.1 0.4 GO:0043279 response to alkaloid(GO:0043279)
0.1 0.4 GO:0060148 negative regulation of hippo signaling(GO:0035331) positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1 0.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.6 GO:0045667 skeletal muscle myosin thick filament assembly(GO:0030241) regulation of osteoblast differentiation(GO:0045667)
0.1 0.3 GO:1902946 protein localization to early endosome(GO:1902946)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.7 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.1 GO:0048659 smooth muscle cell proliferation(GO:0048659)
0.0 0.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.4 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0070861 regulation of protein exit from endoplasmic reticulum(GO:0070861) positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.4 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.1 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 1.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.0 0.4 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.5 GO:0007398 ectoderm development(GO:0007398)
0.0 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.1 GO:1903895 regulation of endoplasmic reticulum unfolded protein response(GO:1900101) negative regulation of endoplasmic reticulum unfolded protein response(GO:1900102) regulation of IRE1-mediated unfolded protein response(GO:1903894) negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.0 0.6 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.2 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0010482 keratinocyte development(GO:0003334) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.2 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.4 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:1901906 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.3 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.2 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.4 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0048016 calcineurin-NFAT signaling cascade(GO:0033173) inositol phosphate-mediated signaling(GO:0048016)
0.0 0.4 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.2 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.4 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.0 0.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.7 GO:0042552 myelination(GO:0042552)
0.0 0.7 GO:0060216 definitive hemopoiesis(GO:0060216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.3 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.0 0.2 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.0 1.1 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.7 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.8 GO:0001726 ruffle(GO:0001726)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.4 GO:0030863 cortical cytoskeleton(GO:0030863)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 0.5 GO:0015168 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.1 1.0 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.7 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.4 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.5 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.4 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.8 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.4 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.2 GO:0070042 rRNA (uridine-N3-)-methyltransferase activity(GO:0070042)
0.1 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.5 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0004775 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.0 0.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 1.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.2 GO:0051429 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0099528 G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.0 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis