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Results for barhl1a+barhl1b
Z-value: 2.61
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Transcription factors associated with barhl1a+barhl1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| barhl1a | dr10_dc_chr5_-_29150278_29150288 | -0.90 | 2.4e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of barhl1a+barhl1b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_44628278 Show fit | 9.36 |
ENSDART00000133572
|
si:ch73-90k17.1 |
|
| chr6_+_23476669 Show fit | 7.69 |
|
|
|
| chr2_-_32404106 Show fit | 6.57 |
ENSDART00000148202
|
upstream binding transcription factor, like |
|
| chr14_+_32578103 Show fit | 5.40 |
ENSDART00000105721
|
ligand of numb-protein X 2b |
|
| chr2_-_2373601 Show fit | 5.38 |
ENSDART00000113774
|
si:ch211-188c16.1 |
|
| chr7_+_24855467 Show fit | 5.31 |
ENSDART00000077217
|
zgc:101765 |
|
| chr14_+_32578253 Show fit | 5.13 |
ENSDART00000105721
|
ligand of numb-protein X 2b |
|
| chr12_+_23543100 Show fit | 4.89 |
ENSDART00000111334
|
mitochondrial poly(A) polymerase |
|
| chr23_-_37553481 Show fit | 4.85 |
|
|
|
| chr16_+_47283253 Show fit | 4.84 |
ENSDART00000062507
|
islet cell autoantigen 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.3 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.5 | 9.6 | GO:0002429 | immune response-activating cell surface receptor signaling pathway(GO:0002429) |
| 0.6 | 8.3 | GO:0050796 | regulation of insulin secretion(GO:0050796) |
| 0.3 | 8.1 | GO:0048263 | determination of dorsal identity(GO:0048263) |
| 0.1 | 6.4 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 1.2 | 6.2 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.9 | 5.3 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 0.8 | 5.3 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.2 | 5.1 | GO:0043631 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.8 | 4.8 | GO:0010525 | regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 8.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.4 | 7.9 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 7.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.2 | 6.2 | GO:0008623 | CHRAC(GO:0008623) |
| 0.1 | 5.9 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 5.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.8 | 5.3 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.3 | 5.3 | GO:1902555 | endoribonuclease complex(GO:1902555) |
| 0.6 | 4.5 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.7 | 4.0 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 16.5 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.1 | 7.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.1 | 6.6 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 1.5 | 6.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 1.2 | 4.9 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.2 | 4.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 4.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 4.4 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 4.0 | GO:0016758 | transferase activity, transferring hexosyl groups(GO:0016758) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 7.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.3 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 2.0 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 1.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 1.8 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.4 | 4.2 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 3.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 3.7 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 3.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 2.9 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 2.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.8 | 2.5 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.3 | 2.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 2.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |