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Results for bcl11aa

Z-value: 0.82

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Transcription factors associated with bcl11aa

Gene Symbol Gene ID Gene Info
bcl11aa
ENSDARG00000061352 BAF chromatin remodeling complex subunit BCL11A a

Activity profile of bcl11aa motif

Sorted Z-values of bcl11aa motif

Network of associatons between targets according to the STRING database.

First level regulatory network of bcl11aa

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_40364675 1.85 ENSDART00000098791
ENSDART00000049171
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr2_+_4366169 1.61 ENSDART00000157903
gata6
GATA binding protein 6
chr20_+_34640226 1.36 ENSDART00000076946
ENSDARG00000054723
ENSDARG00000054723
chr19_+_14197118 1.34 ENSDART00000166230
tpbga
trophoblast glycoprotein a
chr7_-_33994315 1.33 ENSDART00000173596
si:ch211-98n17.5
si:ch211-98n17.5
chr2_+_36916494 1.31 ENSDART00000084859
rabgap1l2
RAB GTPase activating protein 1-like 2
chr24_+_19374200 1.26 ENSDART00000056081
ENSDART00000027022
sulf1
sulfatase 1
chr8_+_47197648 1.23 ENSDART00000137319
si:dkeyp-100a1.6
si:dkeyp-100a1.6
chr15_-_26703761 1.22 ENSDART00000087632
ENSDARG00000079340
ENSDARG00000079340
KN149817v1_+_2207 1.14

chr19_+_30210743 1.07 ENSDART00000167803
marcksl1b
MARCKS-like 1b
chr6_+_30681170 1.05 ENSDART00000112294
ttc22
tetratricopeptide repeat domain 22
chr11_+_5467173 1.05

chr14_+_24548729 1.03

chr2_+_4366348 0.98 ENSDART00000166476
gata6
GATA binding protein 6
chr24_+_19374099 0.94 ENSDART00000056081
ENSDART00000027022
sulf1
sulfatase 1
chr21_-_11539798 0.83 ENSDART00000144770
cast
calpastatin
chr11_+_7570027 0.79 ENSDART00000091550
adgrl2a
adhesion G protein-coupled receptor L2a
chr9_-_14533551 0.75 ENSDART00000056103
nrp2b
neuropilin 2b
chr11_+_7570097 0.74 ENSDART00000091550
adgrl2a
adhesion G protein-coupled receptor L2a
chr6_-_27963880 0.72 ENSDART00000163747
BX914220.1
ENSDARG00000098603
chr25_-_22791839 0.71 ENSDART00000128250
mob2a
MOB kinase activator 2a
chr14_+_38445969 0.68 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr8_+_47197712 0.66 ENSDART00000137319
si:dkeyp-100a1.6
si:dkeyp-100a1.6
chr17_-_26849495 0.64 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr2_+_4366022 0.62 ENSDART00000157903
gata6
GATA binding protein 6
chr15_-_34709255 0.60 ENSDART00000099792
sostdc1a
sclerostin domain containing 1a
chr8_-_31359923 0.60 ENSDART00000019937
gadd45ga
growth arrest and DNA-damage-inducible, gamma a
chr13_-_5953330 0.59 ENSDART00000099224
dld
deltaD
chr6_+_45917081 0.57 ENSDART00000149450
ENSDART00000149642
h6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr25_-_22791921 0.54 ENSDART00000128250
mob2a
MOB kinase activator 2a
chr5_-_34940744 0.53 ENSDART00000145779
si:dkey-204l11.1
si:dkey-204l11.1
chr14_+_21725253 0.51 ENSDART00000149121
clcf1
cardiotrophin-like cytokine factor 1
chr5_+_34022151 0.50 ENSDART00000141338
enc1
ectodermal-neural cortex 1
chr18_+_22285328 0.49

chr5_-_31301280 0.44 ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr22_-_20284307 0.44 ENSDART00000159604
mbd3b
methyl-CpG binding domain protein 3b
chr6_-_7281412 0.44 ENSDART00000053776
fkbp11
FK506 binding protein 11
chr3_-_25239180 0.37 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr23_+_39227734 0.36 ENSDART00000065331
sall4
spalt-like transcription factor 4
chr19_+_30210491 0.36 ENSDART00000167803
marcksl1b
MARCKS-like 1b
chr4_+_32779187 0.34 ENSDART00000172413
znf1042
zinc finger protein 1042
chr12_+_18622682 0.34 ENSDART00000153456
mkl1b
megakaryoblastic leukemia (translocation) 1b
chr11_+_7570326 0.34 ENSDART00000091550
adgrl2a
adhesion G protein-coupled receptor L2a
chr9_-_12726136 0.34

chr2_+_4366568 0.34 ENSDART00000166476
gata6
GATA binding protein 6
chr10_+_38582701 0.33 ENSDART00000144329
acer3
alkaline ceramidase 3
chr23_+_36208765 0.32 ENSDART00000127174
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr2_-_24661477 0.31 ENSDART00000078975
ENSDART00000155677
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr15_+_29729531 0.30 ENSDART00000135540
nrip1a
nuclear receptor interacting protein 1a
chr19_-_10996809 0.28 ENSDART00000163179
pip5k1aa
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a
chr24_-_21324086 0.27

chr2_+_4366515 0.27 ENSDART00000166476
gata6
GATA binding protein 6
chr1_-_10217300 0.26

chr7_-_25991743 0.26 ENSDART00000137769
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr11_-_18068313 0.26

chr13_+_24703728 0.25 ENSDART00000101274
zgc:153981
zgc:153981
chr19_+_14197020 0.25 ENSDART00000166230
tpbga
trophoblast glycoprotein a
chr6_-_52714750 0.25

chr20_+_34640189 0.25 ENSDART00000076946
ENSDARG00000054723
ENSDARG00000054723
chr22_+_9841541 0.25 ENSDART00000141085
si:dkey-253d23.4
si:dkey-253d23.4
chr19_+_30211052 0.24 ENSDART00000051804
marcksl1b
MARCKS-like 1b
chr23_+_41015697 0.23 ENSDART00000115161
reps2
RALBP1 associated Eps domain containing 2
chr11_+_24582928 0.22 ENSDART00000135443
kdm5ba
lysine (K)-specific demethylase 5Ba
chr25_-_19951695 0.21 ENSDART00000104315
zgc:136858
zgc:136858
chr18_+_6692267 0.20

chr11_+_8119829 0.20 ENSDART00000011183
prkacba
protein kinase, cAMP-dependent, catalytic, beta a
chr19_+_31046291 0.20 ENSDART00000052124
fam49al
family with sequence similarity 49, member A-like
chr23_-_39227643 0.18

chr24_+_37834148 0.18

chr13_+_24703802 0.18 ENSDART00000101274
zgc:153981
zgc:153981
chr3_-_6002591 0.17

chr3_-_25238896 0.16 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr6_-_40654280 0.16

chr19_+_10640023 0.16 ENSDART00000148353
usf2
upstream transcription factor 2, c-fos interacting
chr25_+_15901561 0.15 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr16_+_26566014 0.15 ENSDART00000041787
trim35-28
tripartite motif containing 35-28
chr6_-_7281346 0.13 ENSDART00000133096
fkbp11
FK506 binding protein 11
chr25_+_5232865 0.13

chr19_-_22904687 0.12 ENSDART00000141503
pleca
plectin a
chr23_+_36208816 0.12 ENSDART00000127174
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr21_-_10698972 0.11

chr4_+_18975027 0.11 ENSDART00000066973
impdh1b
IMP (inosine 5'-monophosphate) dehydrogenase 1b
chr16_+_25425398 0.10

chr2_+_12472224 0.10 ENSDART00000013454
prtfdc1
phosphoribosyl transferase domain containing 1
chr19_+_30211126 0.09 ENSDART00000051804
marcksl1b
MARCKS-like 1b
chr23_-_17174825 0.09 ENSDART00000053418
dnmt3bb.1
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
chr2_+_22196971 0.08 ENSDART00000140012
ca8
carbonic anhydrase VIII
chr8_+_26336302 0.08

chr15_+_40130393 0.08 ENSDART00000063786
cab39
calcium binding protein 39
chr25_+_5232982 0.08

chr3_+_26603352 0.08 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr9_+_30301667 0.08 ENSDART00000013591
tfg
trk-fused gene
chr23_-_3813451 0.08

chr10_-_22180856 0.08 ENSDART00000006173
cldn7b
claudin 7b
chr4_+_16721264 0.08 ENSDART00000035899
pkp2
plakophilin 2
chr13_+_18130206 0.08

chr5_-_21578927 0.07 ENSDART00000020908
zc4h2
zinc finger, C4H2 domain containing
chr3_+_54506912 0.07 ENSDART00000135913
si:ch211-74m13.1
si:ch211-74m13.1
chr20_+_15119519 0.07 ENSDART00000039345
myoc
myocilin
chr7_-_25991876 0.06 ENSDART00000101109
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr2_+_43693486 0.06

chr19_-_11480368 0.06 ENSDART00000080762
sept7a
septin 7a
chr8_+_21321765 0.06 ENSDART00000131691
alas2
aminolevulinate, delta-, synthase 2
chr22_-_36705684 0.06

chr24_-_13118075 0.05

chr21_+_10699071 0.05

chr25_+_15901662 0.05 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr16_-_50139709 0.05

chr20_-_36905932 0.04 ENSDART00000166966
slc25a27
solute carrier family 25, member 27
chr23_-_17174766 0.04 ENSDART00000053418
dnmt3bb.1
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
chr16_-_22947908 0.04 ENSDART00000133910
shc1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_+_28464109 0.04 ENSDART00000085648
lig4
ligase IV, DNA, ATP-dependent
chr21_-_25765319 0.04 ENSDART00000101219
mettl27
methyltransferase like 27
chr5_-_37521979 0.03 ENSDART00000141791
ENSDART00000170528
si:ch211-284e13.6
si:ch211-284e13.6
chr5_+_60871396 0.03 ENSDART00000131937
orai2
ORAI calcium release-activated calcium modulator 2
chr4_+_16721069 0.03 ENSDART00000035899
pkp2
plakophilin 2
chr7_-_25991514 0.03 ENSDART00000137769
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr23_+_36208651 0.02 ENSDART00000127174
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr4_+_23396557 0.02 ENSDART00000066909
slc35e3
solute carrier family 35, member E3
chr23_+_22052045 0.02 ENSDART00000145172
eif4g3b
eukaryotic translation initiation factor 4 gamma, 3b
chr10_-_35377693 0.02 ENSDART00000131268
rhbdd2
rhomboid domain containing 2
chr2_-_22173254 0.01 ENSDART00000137538
rab2a
RAB2A, member RAS oncogene family
chr17_+_15425559 0.01 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr7_-_29300402 0.01 ENSDART00000099477
rorab
RAR-related orphan receptor A, paralog b
chr25_-_19951796 0.01 ENSDART00000104315
zgc:136858
zgc:136858
chr2_+_22196842 0.01 ENSDART00000140012
ca8
carbonic anhydrase VIII
chr19_-_7606443 0.00 ENSDART00000092256
mrpl9
mitochondrial ribosomal protein L9
chr13_+_18130077 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.5 3.8 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028)
0.3 1.6 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 0.6 GO:0045168 cell-cell signaling involved in cell fate commitment(GO:0045168)
0.1 0.8 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 0.7 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.1 0.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:0070572 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.6 GO:0031641 regulation of myelination(GO:0031641)
0.1 0.6 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.3 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 1.9 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 1.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.4 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 1.8 GO:0003407 neural retina development(GO:0003407)
0.0 0.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0010737 protein kinase A signaling(GO:0010737)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 2.2 GO:0005795 Golgi stack(GO:0005795)
0.0 0.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.6 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.6 GO:0036122 BMP binding(GO:0036122)
0.1 0.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0001727 lipid kinase activity(GO:0001727)
0.0 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0005112 Notch binding(GO:0005112) PDZ domain binding(GO:0030165)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 1.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 2.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 ST JNK MAPK PATHWAY JNK MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 3.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis