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Results for bhlhe40

Z-value: 0.56

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Transcription factors associated with bhlhe40

Gene Symbol Gene ID Gene Info
bhlhe40
ENSDARG00000004060 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe40dr10_dc_chr11_-_35501227_35501356-0.862.0e-05Click!

Activity profile of bhlhe40 motif

Sorted Z-values of bhlhe40 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlhe40

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_15536640 2.10 ENSDART00000098970
lin28a
lin-28 homolog A (C. elegans)
chr17_+_32670368 1.25 ENSDART00000142449
ctsba
cathepsin Ba
chr7_+_22027528 1.07 ENSDART00000056790
tmem256
transmembrane protein 256
chr23_+_26153043 1.03 ENSDART00000054013
atp6ap1b
ATPase, H+ transporting, lysosomal accessory protein 1b
chr5_-_56539892 0.94

chr12_+_18407380 0.94 ENSDART00000146260
msrb1b
methionine sulfoxide reductase B1b
chr9_-_34459799 0.94 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr3_+_16772351 0.92 ENSDART00000164895
atp6v0a1a
ATPase, H+ transporting, lysosomal V0 subunit a1a
chr9_-_10833577 0.87 ENSDART00000078348
ENSDART00000134911
si:ch1073-416j23.1
si:ch1073-416j23.1
chr3_+_13780104 0.86 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr24_+_12845339 0.85 ENSDART00000126842
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr10_+_32107014 0.82 ENSDART00000137373
si:ch211-266i6.3
si:ch211-266i6.3
chr12_+_18407435 0.78 ENSDART00000146260
msrb1b
methionine sulfoxide reductase B1b
chr23_+_35748728 0.74 ENSDART00000143935
rarga
retinoic acid receptor gamma a
chr25_-_19510499 0.72 ENSDART00000166824
gtse1
G-2 and S-phase expressed 1
chr6_+_40924559 0.71 ENSDART00000133599
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr5_+_56539999 0.71 ENSDART00000167660
pja2
praja ring finger 2
chr7_+_22027602 0.69 ENSDART00000056790
tmem256
transmembrane protein 256
chr20_-_51287350 0.69 ENSDART00000023488
atp6v1d
ATPase, H+ transporting, lysosomal V1 subunit D
chr19_+_791656 0.68 ENSDART00000138406
tmem79a
transmembrane protein 79a
chr10_-_44441390 0.68 ENSDART00000160231
sbno1
strawberry notch homolog 1 (Drosophila)
chr1_-_46423056 0.65 ENSDART00000053157
setd4
SET domain containing 4
chr14_-_36004908 0.65 ENSDART00000077823
lrit3a
info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a
chr9_-_34459768 0.64 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr8_-_47339228 0.64 ENSDART00000060853
pex10
peroxisomal biogenesis factor 10
chr15_+_1569674 0.63 ENSDART00000130413
smc4
structural maintenance of chromosomes 4
chr5_+_25604404 0.63 ENSDART00000137178
marveld2b
MARVEL domain containing 2b
chr16_+_25381315 0.62 ENSDART00000114528
tbc1d31
TBC1 domain family, member 31
chr10_-_44441197 0.62 ENSDART00000160231
sbno1
strawberry notch homolog 1 (Drosophila)
chr6_-_49548896 0.61 ENSDART00000169678
ppp4r1l
protein phosphatase 4, regulatory subunit 1-like
chr12_+_47097965 0.60 ENSDART00000084714
zranb1a
zinc finger, RAN-binding domain containing 1a
chr4_+_17666992 0.60 ENSDART00000066999
ccdc53
coiled-coil domain containing 53
chr12_-_7246994 0.58 ENSDART00000061633
zgc:171971
zgc:171971
chr8_-_47339136 0.56 ENSDART00000060853
pex10
peroxisomal biogenesis factor 10
chr11_+_5553243 0.55 ENSDART00000027850
slc35e1
solute carrier family 35, member E1
chr9_-_10833656 0.55 ENSDART00000078348
ENSDART00000134911
si:ch1073-416j23.1
si:ch1073-416j23.1
chr16_+_8067699 0.54 ENSDART00000126041
ano10a
anoctamin 10a
chr6_+_131451 0.53 ENSDART00000166361
fdx1l
ferredoxin 1-like
chr18_+_14715573 0.52 ENSDART00000108469
spata2l
spermatogenesis associated 2-like
chr3_+_13780013 0.51 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr6_-_49548929 0.48 ENSDART00000169678
ppp4r1l
protein phosphatase 4, regulatory subunit 1-like
chr17_+_30826890 0.46 ENSDART00000149600
tpp1
tripeptidyl peptidase I
chr3_+_34051311 0.45 ENSDART00000055252
TIMM29
translocase of inner mitochondrial membrane 29
chr21_+_43183835 0.44 ENSDART00000175107
aff4
AF4/FMR2 family, member 4
chr25_-_19510386 0.41 ENSDART00000147223
gtse1
G-2 and S-phase expressed 1
chr25_-_35094522 0.40 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr13_+_9852854 0.40 ENSDART00000022051
gins1
GINS complex subunit 1 (Psf1 homolog)
chr16_+_19223683 0.38 ENSDART00000115263
ENSDART00000114954
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr18_-_35152017 0.37

chr3_-_25290808 0.37 ENSDART00000154200
bptf
bromodomain PHD finger transcription factor
chr17_-_15221715 0.36 ENSDART00000039165
styx
serine/threonine/tyrosine interacting protein
chr19_+_40792676 0.36 ENSDART00000110699
vps50
VPS50 EARP/GARPII complex subunit
chr1_-_46423011 0.34 ENSDART00000144899
setd4
SET domain containing 4
chr7_-_41601001 0.34 ENSDART00000174258
zgc:92818
zgc:92818
chr20_-_13244237 0.34 ENSDART00000124470
ints7
integrator complex subunit 7
chr9_-_34459378 0.32 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr8_-_47339092 0.32 ENSDART00000060853
pex10
peroxisomal biogenesis factor 10
chr17_-_1949701 0.32 ENSDART00000013093
ENSDART00000168231
ENSDART00000166833
zfyve19
zinc finger, FYVE domain containing 19
chr4_-_9195261 0.31 ENSDART00000080943
hcfc2
host cell factor C2
chr23_-_31986679 0.31 ENSDART00000085054
mtfr2
mitochondrial fission regulator 2
chr15_-_41849769 0.30 ENSDART00000156819
slc25a36b
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36b
chr6_-_40924459 0.29 ENSDART00000076097
sfi1
SFI1 centrin binding protein
chr18_+_41521876 0.28 ENSDART00000136692
ccnl1a
cyclin L1a
chr13_+_40566900 0.28 ENSDART00000057047
hps1
Hermansky-Pudlak syndrome 1
chr5_+_59394192 0.27

chr5_-_21627098 0.27 ENSDART00000138606
las1l
LAS1-like, ribosome biogenesis factor
chr7_+_28782951 0.26

chr23_-_10851353 0.26 ENSDART00000055038
rybpa
RING1 and YY1 binding protein a
chr13_+_29161591 0.26 ENSDART00000115023
PARG
poly(ADP-ribose) glycohydrolase
chr3_+_12633142 0.25 ENSDART00000168382
cyp2k8
cytochrome P450, family 2, subfamily K, polypeptide 8
chr20_+_40869277 0.24 ENSDART00000144401
tbc1d32
TBC1 domain family, member 32
chr3_+_35310412 0.23 ENSDART00000176700
BX511029.1
ENSDARG00000107881
chr25_+_3662390 0.23 ENSDART00000154008
chid1
chitinase domain containing 1
chr20_+_14073428 0.22 ENSDART00000049864
rd3
retinal degeneration 3
chr17_+_30827047 0.22 ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr15_+_1569864 0.18 ENSDART00000056765
smc4
structural maintenance of chromosomes 4
chr5_+_59394222 0.16

chr16_+_6789780 0.16 ENSDART00000149742
znf407
zinc finger protein 407
chr16_+_8067533 0.15 ENSDART00000126041
ano10a
anoctamin 10a
chr21_+_43183570 0.15 ENSDART00000151512
aff4
AF4/FMR2 family, member 4
chr19_+_9192592 0.13 ENSDART00000060442
setdb1a
SET domain, bifurcated 1a
chr19_+_7255491 0.13 ENSDART00000151220
hsd17b8
hydroxysteroid (17-beta) dehydrogenase 8
chr20_-_51287382 0.13 ENSDART00000023488
atp6v1d
ATPase, H+ transporting, lysosomal V1 subunit D
chr24_+_33548367 0.12 ENSDART00000166666
zgc:101800
zgc:101800
chr20_+_14073464 0.12 ENSDART00000049864
rd3
retinal degeneration 3
chr20_-_29780783 0.11 ENSDART00000131219
ENSDART00000015928
si:ch211-195d17.2
si:ch211-195d17.2
chr20_-_40869235 0.10 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr5_+_19506512 0.10 ENSDART00000047841
sgsm1a
small G protein signaling modulator 1a
chr3_+_16772396 0.09 ENSDART00000164895
atp6v0a1a
ATPase, H+ transporting, lysosomal V0 subunit a1a
chr8_-_25797849 0.08 ENSDART00000099364
taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr11_+_5553275 0.08 ENSDART00000027850
slc35e1
solute carrier family 35, member E1
chr15_-_44054313 0.07 ENSDART00000110112
lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr15_-_26638024 0.07 ENSDART00000156621
wdr81
WD repeat domain 81
chr21_+_11824091 0.06 ENSDART00000136103
ubap2a
ubiquitin associated protein 2a
chr17_-_37351769 0.06 ENSDART00000153522
ptgr2
prostaglandin reductase 2
chr5_-_62762761 0.05 ENSDART00000163246
cntrl
centriolin
chr19_+_40792612 0.05 ENSDART00000017917
vps50
VPS50 EARP/GARPII complex subunit
chr23_+_26152909 0.03 ENSDART00000129617
atp6ap1b
ATPase, H+ transporting, lysosomal accessory protein 1b
chr13_+_11741597 0.02

chr9_+_16846294 0.01 ENSDART00000110866
cln5
ceroid-lipofuscinosis, neuronal 5
chr23_+_35748258 0.00 ENSDART00000129222
rarga
retinoic acid receptor gamma a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0008057 eye pigment granule organization(GO:0008057)
0.2 0.6 GO:0071947 protein K29-linked deubiquitination(GO:0035523) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
0.2 1.4 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1 1.0 GO:0001845 phagolysosome assembly(GO:0001845)
0.1 0.4 GO:0043393 regulation of protein binding(GO:0043393)
0.1 1.5 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 1.9 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.1 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.3 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.2 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.1 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.4 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.4 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0070828 heterochromatin organization(GO:0070828)
0.0 1.2 GO:0031101 fin regeneration(GO:0031101)
0.0 0.5 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.4 GO:0032456 endocytic recycling(GO:0032456)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0000801 central element(GO:0000801)
0.2 1.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.4 GO:1990745 EARP complex(GO:1990745)
0.1 1.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.3 GO:0031085 BLOC-3 complex(GO:0031085)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.1 0.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.8 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.0 1.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.1 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.2 GO:0005764 lysosome(GO:0005764)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.2 0.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.0 GO:0051117 ATPase binding(GO:0051117)
0.1 0.3 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.2 GO:0008061 chitin binding(GO:0008061)
0.1 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0047522 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.9 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.6 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)