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Results for cers4a+hoxb13a

Z-value: 0.39

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Transcription factors associated with cers4a+hoxb13a

Gene Symbol Gene ID Gene Info
cers4a
ENSDARG00000031387 ceramide synthase 4a
hoxb13a
ENSDARG00000056015 homeobox B13a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cers4adr10_dc_chr22_+_4323147_43232290.194.8e-01Click!
hoxb13adr10_dc_chr3_+_23523703_23523716-0.097.5e-01Click!

Activity profile of cers4a+hoxb13a motif

Sorted Z-values of cers4a+hoxb13a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of cers4a+hoxb13a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_6274169 1.05 ENSDART00000140347
ENSDART00000092656
erf
Ets2 repressor factor
chr8_+_45326435 1.02 ENSDART00000134161
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr5_-_23211957 0.88 ENSDART00000019992
gbgt1l1
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1
chr24_+_8702288 0.79 ENSDART00000114810
sycp2l
synaptonemal complex protein 2-like
chr10_-_14971273 0.74 ENSDART00000137430
smad2
SMAD family member 2
chr10_-_14971565 0.57 ENSDART00000147653
smad2
SMAD family member 2
chr12_-_34657387 0.57 ENSDART00000153418
bahcc1b
BAH domain and coiled-coil containing 1b
chr6_-_6101185 0.55 ENSDART00000125918
ENSDART00000126142
ENSDART00000081966
rtn4a
reticulon 4a
chr7_-_26226924 0.53 ENSDART00000058910
sox19b
SRY (sex determining region Y)-box 19b
chr19_-_6274237 0.53 ENSDART00000151405
erf
Ets2 repressor factor
chr19_-_6274458 0.52 ENSDART00000151405
erf
Ets2 repressor factor
chr6_-_6101145 0.50 ENSDART00000125918
ENSDART00000126142
ENSDART00000081966
rtn4a
reticulon 4a
chr23_-_14118530 0.48 ENSDART00000139406
g6pd
glucose-6-phosphate dehydrogenase
chr13_-_26668719 0.45 ENSDART00000139264
vrk2
vaccinia related kinase 2
chr20_+_23707625 0.44

chr10_+_32122404 0.39 ENSDART00000062311
ENSDART00000124166
si:dkey-250d21.1
si:dkey-250d21.1
chr13_-_35766296 0.38 ENSDART00000162399
tacc3
transforming, acidic coiled-coil containing protein 3
chr6_-_6101371 0.37 ENSDART00000125918
ENSDART00000126142
ENSDART00000081966
rtn4a
reticulon 4a
chr7_-_26226628 0.37 ENSDART00000058910
sox19b
SRY (sex determining region Y)-box 19b
chr3_-_42949526 0.36 ENSDART00000161127
axin1
axin 1
chr10_+_32122225 0.35 ENSDART00000062311
ENSDART00000124166
si:dkey-250d21.1
si:dkey-250d21.1
chr5_+_22006830 0.35 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr9_+_32838316 0.35 ENSDART00000172033
rabl3
RAB, member of RAS oncogene family-like 3
chr3_-_42949616 0.34 ENSDART00000161127
axin1
axin 1
chr11_+_24076576 0.34 ENSDART00000171491
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr15_-_5810906 0.34 ENSDART00000142334
hnrnpl2
heterogeneous nuclear ribonucleoprotein L2
chr1_-_8565788 0.34 ENSDART00000055011
zgc:136472
zgc:136472
chr10_+_32122560 0.34 ENSDART00000062311
ENSDART00000124166
si:dkey-250d21.1
si:dkey-250d21.1
KN149795v1_-_10712 0.34

chr25_-_35094522 0.33 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr10_-_6587281 0.33 ENSDART00000163788
ENSDART00000171833
chd1
chromodomain helicase DNA binding protein 1
chr20_+_23707789 0.33

chr18_+_20479090 0.32 ENSDART00000100665
ENSDART00000147867
ddb2
damage-specific DNA binding protein 2
chr13_+_12651744 0.31 ENSDART00000090000
si:ch211-233a24.2
si:ch211-233a24.2
chr7_+_23799153 0.31

chr10_-_6587375 0.29 ENSDART00000163788
ENSDART00000171833
chd1
chromodomain helicase DNA binding protein 1
chr24_+_17044956 0.29

KN150703v1_-_14537 0.28 ENSDART00000170148
CABZ01081748.1
ENSDARG00000098362
chr10_+_20435169 0.26 ENSDART00000160803
r3hcc1
R3H domain and coiled-coil containing 1
chr23_-_24299965 0.26 ENSDART00000109134
plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr19_-_2651862 0.26 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr3_+_48319803 0.24 ENSDART00000113531
mkl2b
MKL/myocardin-like 2b
chr23_+_31669909 0.24 ENSDART00000053534
tbpl1
TBP-like 1
chr2_+_35613093 0.24 ENSDART00000098734
cacybp
calcyclin binding protein
chr9_+_2336680 0.23 ENSDART00000016417
atp5g3a
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9), genome duplicate a
chr24_+_37805069 0.23

chr8_+_45326523 0.23 ENSDART00000145011
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr12_-_36415669 0.22

chr12_+_22137718 0.20 ENSDART00000131175
wnt3
wingless-type MMTV integration site family, member 3
chr7_-_20593964 0.19 ENSDART00000135509
fis1
fission, mitochondrial 1
chr3_+_59767380 0.18

chr8_+_24721104 0.17 ENSDART00000126897
lamtor5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr9_-_32837850 0.17 ENSDART00000123374
dnajb11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr9_-_2886135 0.17 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr10_-_6587323 0.17 ENSDART00000163788
ENSDART00000171833
chd1
chromodomain helicase DNA binding protein 1
chr8_+_50964745 0.17 ENSDART00000013870
ENSDARG00000007359
ENSDARG00000007359
chr11_+_44696399 0.15 ENSDART00000158188
mgea5l
meningioma expressed antigen 5 (hyaluronidase) like
chr2_+_16928379 0.15 ENSDART00000160641
ENSDART00000125413
xrn1
5'-3' exoribonuclease 1
chr9_+_28420902 0.15

chr20_-_19611952 0.15 ENSDART00000040191
snx17
sorting nexin 17
chr6_-_54049582 0.14

chr20_-_27834646 0.13 ENSDART00000138139
zgc:153157
zgc:153157
chr3_-_49082769 0.12 ENSDART00000131913
hgs
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_-_34521855 0.11 ENSDART00000039847
ENSDART00000135725
chchd4a
coiled-coil-helix-coiled-coil-helix domain containing 4a
chr10_-_14971401 0.10 ENSDART00000044756
ENSDART00000128579
smad2
SMAD family member 2
chr13_+_17564330 0.09 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr11_-_30364626 0.09 ENSDART00000089803
ENSDART00000046800
ENSDART00000172244
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr2_+_35612974 0.08 ENSDART00000098734
cacybp
calcyclin binding protein
KN149711v1_-_7827 0.08 ENSDART00000171410
ENSDARG00000104905
ENSDARG00000104905
chr24_-_36349914 0.06 ENSDART00000155725
tmem241
transmembrane protein 241
chr17_+_31803551 0.05 ENSDART00000159254
mettl10
methyltransferase like 10
chr8_+_24720852 0.03 ENSDART00000126897
lamtor5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr23_-_14118662 0.03 ENSDART00000104834
g6pd
glucose-6-phosphate dehydrogenase
chr11_-_30364563 0.03 ENSDART00000165501
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr1_-_33700550 0.02

chr10_+_39142185 0.02

chr11_+_44696462 0.01 ENSDART00000158188
mgea5l
meningioma expressed antigen 5 (hyaluronidase) like
chr16_+_36465436 0.01 ENSDART00000158358
stk40
serine/threonine kinase 40
chr16_+_36465373 0.00 ENSDART00000158358
stk40
serine/threonine kinase 40

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.2 1.4 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.7 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.1 0.9 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.3 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746) regulation of protein lipidation(GO:1903059)
0.1 0.3 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.5 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.3 GO:1903729 membrane tubulation(GO:0097320) regulation of plasma membrane organization(GO:1903729)
0.0 0.9 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.2 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.3 GO:0009411 response to UV(GO:0009411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.2 0.5 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 1.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.7 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER