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Results for creb1a+creb1b
Z-value: 5.52
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Transcription factors associated with creb1a+creb1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| creb1a | dr10_dc_chr1_-_32825385_32825433 | 0.46 | 7.1e-02 | Click! |
| creb1b | dr10_dc_chr9_-_28464146_28464209 | -0.21 | 4.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of creb1a+creb1b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_28429523 Show fit | 7.54 |
ENSDART00000111603
|
zinc finger protein 1041 |
|
| chr4_+_51798289 Show fit | 6.72 |
|
|
|
| chr4_+_46096104 Show fit | 6.21 |
|
|
|
| chr4_-_71302151 Show fit | 5.92 |
|
|
|
| chr4_-_44665935 Show fit | 5.92 |
ENSDART00000150524
|
si:ch211-162i8.4 |
|
| chr4_+_30499948 Show fit | 5.89 |
ENSDART00000164555
|
si:dkey-199m13.4 |
|
| KN149695v1_-_61011 Show fit | 5.86 |
ENSDART00000160846
|
ENSDARG00000098877 |
|
| chr4_+_50303963 Show fit | 5.84 |
ENSDART00000170022
|
zgc:173705 |
|
| chr4_-_32820181 Show fit | 5.66 |
|
|
|
| chr4_+_40119702 Show fit | 5.53 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 212.7 | GO:0006355 | regulation of transcription, DNA-templated(GO:0006355) |
| 0.0 | 16.5 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.4 | 13.1 | GO:0009408 | response to heat(GO:0009408) |
| 0.1 | 10.6 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.3 | 10.1 | GO:1902038 | positive regulation of hematopoietic stem cell differentiation(GO:1902038) |
| 0.5 | 9.7 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.2 | 5.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 4.6 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 4.3 | GO:0006396 | RNA processing(GO:0006396) |
| 0.1 | 4.1 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 133.7 | GO:0005634 | nucleus(GO:0005634) |
| 0.7 | 11.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 10.4 | GO:0005730 | nucleolus(GO:0005730) |
| 1.1 | 10.1 | GO:0032021 | NELF complex(GO:0032021) |
| 0.1 | 5.2 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 4.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 3.9 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 3.7 | GO:0005694 | chromosome(GO:0005694) |
| 0.1 | 3.7 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.1 | 3.6 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 222.1 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.0 | 42.3 | GO:0003723 | RNA binding(GO:0003723) |
| 1.6 | 6.2 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 0.0 | 5.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 5.0 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.2 | 4.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.6 | 4.6 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.5 | 3.7 | GO:0043035 | chromatin insulator sequence binding(GO:0043035) |
| 0.2 | 3.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 1.2 | 3.5 | GO:0030623 | U5 snRNA binding(GO:0030623) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.1 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 1.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 4.9 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 4.8 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.2 | 4.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 3.9 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 3.5 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 1.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.7 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 1.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 1.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |