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Results for dmbx1a+dmbx1b

Z-value: 0.56

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Transcription factors associated with dmbx1a+dmbx1b

Gene Symbol Gene ID Gene Info
dmbx1b
ENSDARG00000002510 diencephalon/mesencephalon homeobox 1b
dmbx1a
ENSDARG00000009922 diencephalon/mesencephalon homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dmbx1bdr10_dc_chr6_-_3413472_3413503-0.185.0e-01Click!
dmbx1adr10_dc_chr2_-_10394639_10394685-0.146.0e-01Click!

Activity profile of dmbx1a+dmbx1b motif

Sorted Z-values of dmbx1a+dmbx1b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of dmbx1a+dmbx1b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_37732100 2.10

chr11_-_34367105 0.87 ENSDART00000157625
mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr10_+_8670564 0.83 ENSDART00000129643
aplnrb
apelin receptor b
chr1_-_11439671 0.78 ENSDART00000164817
mtp
microsomal triglyceride transfer protein
chr4_-_16639774 0.76 ENSDART00000125323
caprin2
caprin family member 2
chr15_-_41777233 0.68 ENSDART00000154230
ftr90
finTRIM family, member 90
chr25_-_34616997 0.58 ENSDART00000137502
si:ch73-36p18.1
si:ch73-36p18.1
chr23_-_3816492 0.54 ENSDART00000136394
hmga1a
high mobility group AT-hook 1a
chr8_+_46319434 0.48 ENSDART00000145618
si:dkey-75a21.2
si:dkey-75a21.2
chr5_+_3597060 0.46

chr3_+_22962233 0.46 ENSDART00000142884
gngt2a
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a
chr23_-_3816422 0.45 ENSDART00000132205
hmga1a
high mobility group AT-hook 1a
chr18_+_5616001 0.42 ENSDART00000163629
dut
deoxyuridine triphosphatase
chr1_+_35217331 0.41

chr12_+_33793468 0.40 ENSDART00000130853
mfsd13a
major facilitator superfamily domain containing 13A
chr15_-_6979997 0.37 ENSDART00000169944
si:ch73-311h14.2
si:ch73-311h14.2
chr22_+_13862110 0.36 ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr20_-_21773202 0.36 ENSDART00000133286
si:ch211-207i1.2
si:ch211-207i1.2
chr5_-_22099244 0.36 ENSDART00000161298
nono
non-POU domain containing, octamer-binding
chr12_+_33793663 0.36 ENSDART00000004769
mfsd13a
major facilitator superfamily domain containing 13A
chr15_-_36072087 0.33 ENSDART00000076229
irs1
insulin receptor substrate 1
chr20_-_21773327 0.32 ENSDART00000133286
si:ch211-207i1.2
si:ch211-207i1.2
chr5_-_22098977 0.31 ENSDART00000011699
nono
non-POU domain containing, octamer-binding
chr10_-_8029671 0.30 ENSDART00000141445
ewsr1a
EWS RNA-binding protein 1a
chr13_-_31807963 0.28 ENSDART00000026726
diexf
digestive organ expansion factor homolog
chr18_-_10744619 0.26 ENSDART00000034817
rbm28
RNA binding motif protein 28
chr15_-_7340623 0.26 ENSDART00000161613
SLC7A1 (1 of many)
solute carrier family 7 member 1
chr16_+_25096883 0.25 ENSDART00000157312
znf1035
zinc finger protein 1035
chr11_-_2437361 0.24

chr5_-_68408107 0.23 ENSDART00000109761
ENSDART00000156681
ENSDART00000167680
ENSDARG00000076888
ENSDARG00000076888
chr22_-_36717838 0.22

chr18_+_50528517 0.22 ENSDART00000151647
ubl7b
ubiquitin-like 7b (bone marrow stromal cell-derived)
KN149926v1_+_2353 0.21

chr5_-_4750799 0.21 ENSDART00000130576
mvb12ba
multivesicular body subunit 12Ba
chr19_+_24741199 0.20 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr25_-_34617182 0.20 ENSDART00000137502
si:ch73-36p18.1
si:ch73-36p18.1
chr16_+_25096821 0.19 ENSDART00000157312
znf1035
zinc finger protein 1035
chr12_+_33793495 0.18 ENSDART00000152988
mfsd13a
major facilitator superfamily domain containing 13A
chr6_-_39655998 0.17 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr2_-_38380883 0.17 ENSDART00000088026
prmt5
protein arginine methyltransferase 5
chr15_-_25825347 0.17 ENSDART00000155332
ENSDART00000154029
CT027805.1
ENSDARG00000097316
chr5_-_23525132 0.17 ENSDART00000051546
rps6ka3a
ribosomal protein S6 kinase a, polypeptide 3a
chr15_-_5575675 0.17 ENSDART00000099520
atg16l2
ATG16 autophagy related 16-like 2 (S. cerevisiae)
chr14_+_30390987 0.17

chr6_-_39656043 0.17 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr2_+_45119713 0.16 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr13_-_38666198 0.16 ENSDART00000162858
lmbrd1
LMBR1 domain containing 1
chr23_-_29627060 0.16 ENSDART00000166554
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr5_-_8313115 0.16 ENSDART00000170921
fgf10b
fibroblast growth factor 10b
chr5_-_68408171 0.15 ENSDART00000109761
ENSDART00000156681
ENSDART00000167680
ENSDARG00000076888
ENSDARG00000076888
chr25_-_34617243 0.15 ENSDART00000137502
si:ch73-36p18.1
si:ch73-36p18.1
chr23_-_27123338 0.14 ENSDART00000142324
ENSDART00000133249
ENSDARG00000025766
ENSDARG00000025766
chr5_-_25133229 0.13 ENSDART00000051566
zgc:101016
zgc:101016
chr9_+_31265296 0.13 ENSDART00000132478
BX470183.1
ENSDARG00000095476
chr5_-_4750869 0.13 ENSDART00000164377
mvb12ba
multivesicular body subunit 12Ba
chr2_-_38380637 0.13 ENSDART00000088026
prmt5
protein arginine methyltransferase 5
chr23_-_533016 0.13 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr21_-_13599764 0.12

chr18_+_5066229 0.12 ENSDART00000157671
CABZ01080599.1
ENSDARG00000100626
chr19_+_24741351 0.12 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr25_-_31970637 0.11 ENSDART00000006124
cops2
COP9 signalosome subunit 2
chr23_-_532974 0.11 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr13_+_40689102 0.11 ENSDART00000016960
prkg1a
protein kinase, cGMP-dependent, type Ia
chr25_-_34617301 0.11 ENSDART00000137502
si:ch73-36p18.1
si:ch73-36p18.1
chr15_-_8215797 0.10 ENSDART00000156663
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr4_-_4247251 0.09 ENSDART00000150279
cd9b
CD9 molecule b
chr25_-_34616837 0.09 ENSDART00000137502
si:ch73-36p18.1
si:ch73-36p18.1
chr13_-_36456275 0.09 ENSDART00000143682
lgals3a
lectin, galactoside binding soluble 3a
chr5_-_25133456 0.08 ENSDART00000051566
zgc:101016
zgc:101016
chr2_+_30800532 0.08

chr15_-_5575746 0.08 ENSDART00000130297
atg16l2
ATG16 autophagy related 16-like 2 (S. cerevisiae)
chr4_-_74907755 0.07 ENSDART00000132323
ftr51
finTRIM family, member 51
chr12_+_31614163 0.07 ENSDART00000152973
RNF157
ring finger protein 157
chr13_-_36456350 0.07 ENSDART00000143682
lgals3a
lectin, galactoside binding soluble 3a
chr17_+_24668907 0.06 ENSDART00000034263
ENSDART00000135794
sepn1
selenoprotein N, 1
chr17_+_10437343 0.06 ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr14_-_49951804 0.04 ENSDART00000021736
scocb
short coiled-coil protein b
chr19_-_1571878 0.04

chr18_-_11216036 0.04 ENSDART00000040500
tspan9a
tetraspanin 9a
chr18_+_5616306 0.03 ENSDART00000163629
dut
deoxyuridine triphosphatase
chr2_-_9946238 0.03 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr8_-_40412363 0.03 ENSDART00000161142
tbc1d10aa
TBC1 domain family, member 10Aa
KN149926v1_+_1959 0.03

chr3_+_47412661 0.03 ENSDART00000155648
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr21_-_3619164 0.02 ENSDART00000133980
scamp1
secretory carrier membrane protein 1
chr2_-_9946148 0.02 ENSDART00000175460
dvl3a
dishevelled segment polarity protein 3a
chr25_+_35861851 0.01

chr17_-_8498935 0.01 ENSDART00000148990
ctbp2a
C-terminal binding protein 2a
chr18_+_5616238 0.00 ENSDART00000163629
dut
deoxyuridine triphosphatase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000055)
0.2 0.8 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of calcium ion transport into cytosol(GO:0010524) positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904323) positive regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904325)
0.2 0.5 GO:0046081 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
0.1 0.3 GO:0044803 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.1 0.2 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) purine deoxyribonucleotide catabolic process(GO:0009155) purine deoxyribonucleoside triphosphate metabolic process(GO:0009215) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.2 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.9 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.2 GO:0039694 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.0 0.7 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:0051256 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.0 0.5 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.2 GO:0030324 respiratory tube development(GO:0030323) lung development(GO:0030324)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0004170 dUTP diphosphatase activity(GO:0004170)
0.1 0.8 GO:0060182 apelin receptor activity(GO:0060182)
0.1 0.3 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.2 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0046527 glucosyltransferase activity(GO:0046527)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism