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Results for e2f3

Z-value: 0.79

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Transcription factors associated with e2f3

Gene Symbol Gene ID Gene Info
e2f3
ENSDARG00000070463 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f3dr10_dc_chr19_-_29707065_297072940.924.2e-07Click!

Activity profile of e2f3 motif

Sorted Z-values of e2f3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr25_+_29219700 2.54 ENSDART00000108692
ENSDART00000077445
pim3
Pim-3 proto-oncogene, serine/threonine kinase
chr14_-_30578373 1.91 ENSDART00000176631
si:ch211-126c2.4
si:ch211-126c2.4
chr8_-_3354396 1.76 ENSDART00000169430
ENSDART00000167187
ENSDART00000170478
FUT9 (1 of many)
fut9b
fucosyltransferase 9
fucosyltransferase 9b
chr11_-_11809024 1.65 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr16_-_37518912 1.64

chr14_+_14536088 1.52 ENSDART00000158291
slbp
stem-loop binding protein
chr20_+_27006101 1.44 ENSDART00000153213
rwdd2b
RWD domain containing 2B
chr19_-_44161905 1.35 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr9_-_7235236 1.33 ENSDART00000092435
mgat4a
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr10_+_16543480 1.31 ENSDART00000121864
slc27a6
solute carrier family 27 (fatty acid transporter), member 6
chr7_-_33965017 1.28

chr20_+_26495546 1.22 ENSDART00000036942
zbtb2b
zinc finger and BTB domain containing 2b
chr23_+_37476457 1.19 ENSDART00000178064
AL954146.3
ENSDARG00000108629
chr7_+_33965084 1.15 ENSDART00000052474
tipin
timeless interacting protein
chr3_-_54352535 1.13 ENSDART00000021977
ENSDART00000078973
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr9_+_22866612 1.04 ENSDART00000131429
ENSDART00000080005
itgb5
integrin, beta 5
chr25_+_35790000 1.02 ENSDART00000152195
si:ch211-113a14.18
si:ch211-113a14.18
chr19_-_44161951 0.99 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr14_-_21779536 0.97

chr6_-_32001100 0.93 ENSDART00000132280
ror1
receptor tyrosine kinase-like orphan receptor 1
chr17_+_6378694 0.93 ENSDART00000062952
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr6_+_60117223 0.82 ENSDART00000008243
prelid3b
PRELI domain containing 3
chr17_-_31061338 0.79

chr9_-_7235272 0.78 ENSDART00000174720
mgat4a
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr5_+_12894381 0.75 ENSDART00000051669
tctn2
tectonic family member 2
chr9_-_2886135 0.67 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr19_-_10295398 0.63 ENSDART00000148225
znf865
zinc finger protein 865
chr21_-_21477462 0.61 ENSDART00000031205
pvrl3b
poliovirus receptor-related 3b
chr11_-_11808973 0.57 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr11_+_44738699 0.56 ENSDART00000172301
ENSDART00000170118
tk1
thymidine kinase 1, soluble
chr16_-_12362566 0.55 ENSDART00000116542
U7
U7 small nuclear RNA
chr20_+_26495186 0.54 ENSDART00000078093
zbtb2b
zinc finger and BTB domain containing 2b
chr17_+_6378932 0.50 ENSDART00000062952
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr6_-_37534996 0.40 ENSDART00000147826
jade3
jade family PHD finger 3
chr14_+_21779325 0.40 ENSDART00000106147
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr6_-_49323847 0.40 ENSDART00000155232
BX569793.1
ENSDARG00000096832
chr20_+_27006042 0.40 ENSDART00000153149
ENSDART00000138249
rwdd2b
RWD domain containing 2B
chr7_+_1372988 0.27

KN150648v1_+_877 0.22

chr19_-_10295122 0.15 ENSDART00000148225
znf865
zinc finger protein 865
chr2_+_21431575 0.14 ENSDART00000109568
pip4k2ab
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b
chr17_-_32826829 0.14 ENSDART00000077459
smyd2a
SET and MYND domain containing 2a
chr8_-_11950254 0.08 ENSDART00000005140
med27
mediator complex subunit 27
chr20_+_26495276 0.08 ENSDART00000078093
zbtb2b
zinc finger and BTB domain containing 2b
chr1_+_9202797 0.05 ENSDART00000135702
rgs11
regulator of G protein signaling 11
chr1_+_35990022 0.04 ENSDART00000111566
tmem184c
transmembrane protein 184C
chr5_-_6384926 0.02 ENSDART00000099977
mex3c
mex-3 RNA binding family member C
chr2_-_44491143 0.01 ENSDART00000084174
lig1
ligase I, DNA, ATP-dependent
chr10_+_16543525 0.01 ENSDART00000121864
slc27a6
solute carrier family 27 (fatty acid transporter), member 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.3 2.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.3 1.1 GO:0043111 replication fork arrest(GO:0043111)
0.2 1.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 2.3 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.7 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.1 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.4 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 0.9 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.1 1.0 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 1.3 GO:0015908 fatty acid transport(GO:0015908)
0.0 2.5 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.7 GO:0048538 thymus development(GO:0048538)
0.0 0.8 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 2.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.6 GO:0006213 pyrimidine nucleoside metabolic process(GO:0006213)
0.0 0.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0046549 retinal cone cell development(GO:0046549)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 2.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.0 GO:0008305 integrin complex(GO:0008305)
0.0 0.8 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 2.3 GO:0005764 lysosome(GO:0005764)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 0.8 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.2 1.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 2.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 2.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 2.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 1.0 GO:0005178 integrin binding(GO:0005178)
0.0 1.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.4 PID ATR PATHWAY ATR signaling pathway
0.0 1.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 1.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 2.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism