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Results for e2f4

Z-value: 0.77

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Transcription factors associated with e2f4

Gene Symbol Gene ID Gene Info
e2f4
ENSDARG00000101578 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f4dr10_dc_chr25_+_17308788_17308907-0.243.8e-01Click!

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_17289857 1.41 ENSDART00000178686
lrmp
lymphoid-restricted membrane protein
chr12_+_47448318 1.39 ENSDART00000152857
fmn2b
formin 2b
chr10_+_6925373 1.28 ENSDART00000128866
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr25_-_34619603 1.11 ENSDART00000114767
FQ312024.1
ENSDARG00000076129
chr7_-_6209659 1.10 ENSDART00000173032
CU457819.4
Histone H3.2
chr25_-_35820568 1.09 ENSDART00000152766
CR354435.4
Histone H2B 1/2
chr7_+_5839103 1.07 ENSDART00000145370
zgc:112234
zgc:112234
chr25_+_34562216 0.99 ENSDART00000154655
CU302436.4
ENSDARG00000092743
chr7_-_73631286 0.99 ENSDART00000129254
zgc:173552
zgc:173552
chr20_-_28531087 0.93 ENSDART00000172133
CABZ01057122.1
ENSDARG00000105192
chr19_-_48731766 0.87 ENSDART00000170726
si:ch73-359m17.2
si:ch73-359m17.2
chr7_+_24610446 0.86 ENSDART00000058843
krcp
kelch repeat-containing protein
chr14_-_27040866 0.85 ENSDART00000173053
CU062454.1
ENSDARG00000105327
chr25_+_34553079 0.84 ENSDART00000156838
zgc:112234
zgc:112234
chr7_+_24543671 0.79 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr25_+_22222336 0.77 ENSDART00000154065
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr23_-_19905270 0.75 ENSDART00000054479
haus7
HAUS augmin-like complex, subunit 7
chr20_-_54160322 0.75 ENSDART00000153435
ppp2r5cb
protein phosphatase 2, regulatory subunit B', gamma b
chr11_-_27378184 0.69 ENSDART00000157337
CR931782.1
ENSDARG00000097455
chr20_-_54160297 0.66 ENSDART00000153435
ppp2r5cb
protein phosphatase 2, regulatory subunit B', gamma b
chr25_-_34604544 0.66 ENSDART00000154856
CU302436.5
Histone H3.2
chr5_+_19944746 0.61 ENSDART00000124545
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr11_+_31417477 0.60 ENSDART00000139900
diaph3
diaphanous-related formin 3
chr7_+_73594790 0.59 ENSDART00000123081
zgc:173552
zgc:173552
chr13_+_15802079 0.58 ENSDART00000131390
fignl1
fidgetin-like 1
chr5_-_22466262 0.57 ENSDART00000172549
si:dkey-237j10.2
si:dkey-237j10.2
chr20_+_34091702 0.57 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr7_+_6402162 0.56

chr3_-_8011385 0.54 ENSDART00000169757
ubn2b
ubinuclein 2b
chr3_+_21928413 0.54 ENSDART00000122782
kansl1b
KAT8 regulatory NSL complex subunit 1b
chr13_-_22776767 0.53 ENSDART00000143097
rufy2
RUN and FYVE domain containing 2
chr20_-_28531019 0.52 ENSDART00000172133
CABZ01057122.1
ENSDARG00000105192
chr13_+_15802118 0.50 ENSDART00000131390
fignl1
fidgetin-like 1
chr14_-_16469435 0.50 ENSDART00000113711
zgc:123335
zgc:123335
chr4_-_16611960 0.49

chr7_+_6402122 0.48

chr25_-_12728011 0.47 ENSDART00000169126
uba2
ubiquitin-like modifier activating enzyme 2
chr6_+_50382153 0.46 ENSDART00000055504
cyc1
cytochrome c-1
chr3_+_62051674 0.45 ENSDART00000113144
zgc:173575
zgc:173575
chr7_-_6293116 0.42 ENSDART00000173413
zgc:112234
zgc:112234
chr7_-_6323808 0.42 ENSDART00000173158
zgc:112234
zgc:112234
chr11_+_24110796 0.41 ENSDART00000089747
nfs1
NFS1 cysteine desulfurase
chr22_-_26254136 0.41 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr21_+_30684976 0.41 ENSDART00000040443
zgc:110224
zgc:110224
chr8_+_8908955 0.40 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr4_-_27109874 0.40 ENSDART00000146459
creld2
cysteine-rich with EGF-like domains 2
chr14_-_16469491 0.40 ENSDART00000113711
zgc:123335
zgc:123335
chr3_+_62101056 0.39

chr19_+_48731885 0.39

chr13_-_22776819 0.38 ENSDART00000143097
rufy2
RUN and FYVE domain containing 2
chr19_+_14490203 0.37 ENSDART00000164386
arid1ab
AT rich interactive domain 1Ab (SWI-like)
chr16_+_54906490 0.34 ENSDART00000126646
ENSDARG00000091079
ENSDARG00000091079
KN149926v1_+_2353 0.33

chr3_+_62051743 0.31 ENSDART00000168063
zgc:173575
zgc:173575
chr7_-_6323664 0.30 ENSDART00000173158
zgc:112234
zgc:112234
chr18_+_44635321 0.30

chr25_+_181958 0.28 ENSDART00000155412
RPS17
ribosomal protein S17
chr8_-_43733891 0.26 ENSDART00000166581
ep400
E1A binding protein p400
chr25_+_34553195 0.26 ENSDART00000156838
zgc:112234
zgc:112234
chr20_+_27193945 0.26 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr4_-_16611908 0.26

chr18_+_17032264 0.25 ENSDART00000100160
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr18_+_39345919 0.24 ENSDART00000012164
tmod2
tropomodulin 2
chr23_-_20592068 0.24 ENSDART00000153767
CR352228.1
ENSDARG00000097895
chr18_-_40763107 0.22 ENSDART00000130397
akt2
v-akt murine thymoma viral oncogene homolog 2
KN149926v1_+_1959 0.20

chr17_-_11214364 0.20 ENSDART00000155976
FP102895.1
ENSDARG00000097935
chr23_+_20592121 0.20 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr22_-_26254217 0.18 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr3_-_23473646 0.18 ENSDART00000078423
atp5g1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr5_+_38499102 0.18 ENSDART00000166657
bmp2k
BMP2 inducible kinase
chr2_-_57973733 0.16 ENSDART00000174670
ENSDART00000176252
CABZ01093382.1
ENSDARG00000105978
chr7_-_6280179 0.15 ENSDART00000173349
CU457819.3
Histone H3.2
chr25_+_34557335 0.14 ENSDART00000089844
zgc:113983
zgc:113983
chr14_-_27041347 0.13 ENSDART00000173053
CU062454.1
ENSDARG00000105327
chr17_+_21495087 0.10 ENSDART00000154633
chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr6_+_54798741 0.09

chr21_-_27376521 0.09 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr13_-_45805308 0.08 ENSDART00000166442
si:ch211-62a1.4
si:ch211-62a1.4
chr14_-_6096120 0.07

chr7_-_6293333 0.06 ENSDART00000173413
zgc:112234
zgc:112234
chr24_+_17201072 0.05 ENSDART00000024722
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr16_-_32174276 0.03 ENSDART00000137699
cnot3a
CCR4-NOT transcription complex, subunit 3a
chr2_+_37854303 0.01 ENSDART00000143203
parp2
poly (ADP-ribose) polymerase 2
chr2_-_37854616 0.00 ENSDART00000171409
mettl17
methyltransferase like 17
chr21_-_27376494 0.00 ENSDART00000011551
ENSDART00000148161
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.3 0.8 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.2 0.6 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.1 1.3 GO:0048608 gonad development(GO:0008406) reproductive structure development(GO:0048608) reproductive system development(GO:0061458)
0.1 1.4 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 0.2 GO:0046326 positive regulation of glucose import(GO:0046326)
0.0 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.2 GO:0000012 single strand break repair(GO:0000012)
0.0 1.4 GO:0045010 actin nucleation(GO:0045010)
0.0 1.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.1 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.6 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.8 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.8 GO:0051225 centrosome cycle(GO:0007098) spindle assembly(GO:0051225)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0061574 ASAP complex(GO:0061574)
0.1 1.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 1.3 GO:0043186 P granule(GO:0043186)
0.0 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0035060 brahma complex(GO:0035060)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.4 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.2 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.4 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0009055 electron carrier activity(GO:0009055)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling