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Results for e2f5_si:ch211-160f23.5

Z-value: 2.15

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Transcription factors associated with e2f5_si:ch211-160f23.5

Gene Symbol Gene ID Gene Info
ENSDARG00000038812 E2F transcription factor 5
ENSDARG00000079233 si_ch211-160f23.5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f5dr10_dc_chr2_-_31703111_317032370.712.2e-03Click!
E2F2dr10_dc_chr17_-_27247516_27247601-0.371.6e-01Click!

Activity profile of e2f5_si:ch211-160f23.5 motif

Sorted Z-values of e2f5_si:ch211-160f23.5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f5_si:ch211-160f23.5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr25_+_22222388 8.58 ENSDART00000154376
cytochrome P450, family 11, subfamily A, polypeptide 1
chr15_-_17163526 8.47 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr2_-_29939721 8.18 ENSDART00000031130
PAX interacting (with transcription-activation domain) protein 1
chr11_-_11809024 7.67 ENSDART00000011657
cell division cycle 6 homolog (S. cerevisiae)
chr3_-_54352535 6.84 ENSDART00000021977
ENSDART00000078973
DNA (cytosine-5-)-methyltransferase 1
chr19_-_6925090 6.31 ENSDART00000081568
transcription factor 19 (SC1), like
chr1_-_7869105 5.60 ENSDART00000147763
zgc:112980
chr6_+_50452131 4.96 ENSDART00000155051
myelocytomatosis oncogene homolog
chr25_+_29219700 4.79 ENSDART00000108692
ENSDART00000077445
Pim-3 proto-oncogene, serine/threonine kinase
chr7_+_55217087 4.71 ENSDART00000149915
chromatin licensing and DNA replication factor 1
chr20_+_35535503 4.50 ENSDART00000153249
tudor domain containing 6
chr19_+_39689450 4.27

chr23_-_36207066 4.03 ENSDART00000147598
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr8_-_25741895 3.92 ENSDART00000140451
suppressor of variegation 3-9 homolog 1b
chr2_+_44659334 3.83 ENSDART00000155017
PAS domain containing serine/threonine kinase
chr5_-_12242927 3.65 ENSDART00000137705
leucine-zipper-like transcription regulator 1
chr20_+_39441958 3.62 ENSDART00000009164
establishment of sister chromatid cohesion N-acetyltransferase 2
chr16_+_41065840 3.58 ENSDART00000124543
DEK proto-oncogene
chr9_-_2886135 3.53 ENSDART00000140695
cell division cycle associated 7a
chr7_-_64745132 3.50 ENSDART00000112166
family with sequence similarity 60, member A, like
chr14_+_21831841 3.41 ENSDART00000132514
cyclin G1
chr3_+_25868700 3.19 ENSDART00000024316
minichromosome maintenance complex component 5
chr25_+_22222336 3.19 ENSDART00000154065
cytochrome P450, family 11, subfamily A, polypeptide 1
chr7_-_33965017 3.14

chr5_+_37019043 3.11

chr6_-_1685041 3.10

chr2_+_37855019 3.09 ENSDART00000113337
poly (ADP-ribose) polymerase 2
chr7_+_33965084 3.09 ENSDART00000052474
timeless interacting protein
chr13_+_7923056 3.04 ENSDART00000080465
helicase, lymphoid-specific
chr19_-_43359719 3.02 ENSDART00000086659
cysteine/histidine-rich 1
chr19_-_29707065 3.00 ENSDART00000130815
ENSDART00000172590
ENSDART00000103437
E2F transcription factor 3
chr16_-_37518912 2.96

chr15_+_17163165 2.94

chr10_+_21477579 2.94 ENSDART00000142447
eukaryotic translation termination factor 1b
chr11_-_11808973 2.89 ENSDART00000011657
cell division cycle 6 homolog (S. cerevisiae)
chr5_+_37018446 2.88

chr23_+_45486958 2.88 ENSDART00000111126
PC4 and SFRS1 interacting protein 1b
chr19_-_20819477 2.85 ENSDART00000151356
deleted in azoospermia-like
chr3_+_26113651 2.82 ENSDART00000103734
ATPase family, AAA domain containing 5a
chr7_+_41532360 2.71 ENSDART00000174333
origin recognition complex, subunit 6
chr19_-_20819101 2.70 ENSDART00000137590
deleted in azoospermia-like
chr8_-_22639164 2.65

chr22_-_38321005 2.62 ENSDART00000015117
ELAV like neuron-specific RNA binding protein 2
chr3_+_26113393 2.50 ENSDART00000103733
ATPase family, AAA domain containing 5a
chr6_+_33947023 2.36 ENSDART00000157397
origin recognition complex, subunit 1
chr2_-_40857927 2.31 ENSDART00000157099
ENSDARG00000096869
chr18_+_15303434 2.30 ENSDART00000099777
ENSDART00000170246
si:dkey-103i16.6
chr3_-_26113336 2.29 ENSDART00000103741
protein phosphatase 4, catalytic subunit a
chr6_+_50452229 2.27 ENSDART00000155051
myelocytomatosis oncogene homolog
chr8_-_4704361 2.26 ENSDART00000064201
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr23_-_36349563 2.26

chr17_-_33754959 2.25 ENSDART00000124788
si:dkey-84k17.2
chr3_-_26112995 2.20 ENSDART00000103741
protein phosphatase 4, catalytic subunit a
chr14_-_31375046 2.15 ENSDART00000173274
MAP7 domain containing 3
chr7_-_41532268 2.14 ENSDART00000016105
ENSDART00000138800
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr8_-_1154220 2.12 ENSDART00000149969
ENSDART00000016800
zinc finger protein 367
chr7_-_68962286 2.12

chr19_-_2928582 2.09 ENSDART00000109130
RecQ helicase-like 4
chr7_-_37624329 2.09 ENSDART00000084282
PAP associated domain containing 5
chr3_-_15960491 2.07 ENSDART00000064838
LIM and SH3 protein 1
chr20_-_44678938 2.06 ENSDART00000148639
UBX domain protein 2A
chr18_-_12889296 2.05 ENSDART00000130343
poly (ADP-ribose) polymerase family, member 12a
chr3_+_22204475 2.03 ENSDART00000055676
ENSDARG00000038186
chr13_-_12898069 2.01 ENSDART00000009499
Wolf-Hirschhorn syndrome candidate 1
chr7_+_71293928 2.01 ENSDART00000047069
thymidylate synthetase
chr7_+_1443102 2.01 ENSDART00000172830
SPT16 homolog, facilitates chromatin remodeling subunit
chr5_+_69178270 2.00 ENSDART00000097359
DnaJ (Hsp40) homolog, subfamily C , member 25
chr20_-_33584483 1.96 ENSDART00000177645
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr2_+_38073166 1.94 ENSDART00000145642
si:rp71-1g18.1
chr18_+_50920737 1.93 ENSDART00000174305
cortactin
chr21_-_19879125 1.92 ENSDART00000164317
exoribonuclease 1
chr5_+_37018996 1.92

chr13_-_35782121 1.90 ENSDART00000013961
MYCL proto-oncogene, bHLH transcription factor a
chr19_+_9536231 1.89 ENSDART00000139385
si:ch211-288g17.3
chr12_+_47448318 1.89 ENSDART00000152857
formin 2b
chr25_+_29752983 1.86 ENSDART00000141167
hydroxysteroid (17-beta) dehydrogenase 12a
chr19_-_10295398 1.86 ENSDART00000148225
zinc finger protein 865
chr7_-_37624410 1.86 ENSDART00000084282
PAP associated domain containing 5
chr17_-_22552999 1.85 ENSDART00000141523
exonuclease 1
chr6_-_25081182 1.85 ENSDART00000161585
leucine rich repeat containing 8 family, member Db
chr24_-_35673629 1.83 ENSDART00000058564
minichromosome maintenance complex component 4
chr18_-_12889369 1.81 ENSDART00000130343
poly (ADP-ribose) polymerase family, member 12a
chr5_+_19944746 1.79 ENSDART00000124545
squamous cell carcinoma antigen recognized by T cells 3
chr3_+_26212025 1.78 ENSDART00000163832
si:ch211-156b7.4
chr22_+_2524697 1.78

chr19_-_29706969 1.78 ENSDART00000130815
ENSDART00000172590
ENSDART00000103437
E2F transcription factor 3
chr21_+_22521573 1.77 ENSDART00000157593
ENSDART00000167599
checkpoint kinase 1
chr5_-_53748764 1.75 ENSDART00000160781
ENSDART00000160965
ENSDART00000161692
zinc finger, MYND-type containing 19
chr22_-_10562118 1.74 ENSDART00000105846
si:dkey-42i9.8
chr5_+_33949157 1.74 ENSDART00000136787
allograft inflammatory factor 1-like
chr11_+_41777220 1.71 ENSDART00000172846
calmodulin binding transcription activator 1
chr10_-_21404605 1.69 ENSDART00000125167
avidin
chr19_-_9044008 1.64 ENSDART00000104657
mitochondrial ribosomal protein S21
chr7_-_40386766 1.63 ENSDART00000084153
nucleolar protein with MIF4G domain 1
chr8_-_3354396 1.63 ENSDART00000169430
ENSDART00000167187
ENSDART00000170478
fucosyltransferase 9
fucosyltransferase 9b
chr8_-_40287530 1.62 ENSDART00000074125
apelin receptor a
chr13_+_20393886 1.60 ENSDART00000081385
coiled-coil domain containing 172
chr13_-_12898263 1.59 ENSDART00000009499
Wolf-Hirschhorn syndrome candidate 1
chr5_+_33949689 1.58 ENSDART00000139317
allograft inflammatory factor 1-like
chr14_-_5103890 1.56

chr5_+_58009274 1.54 ENSDART00000019561
zgc:171734
chr22_+_1633211 1.54 ENSDART00000160854
ENSDARG00000104479
chr3_+_36970806 1.54 ENSDART00000055228
PSMC3 interacting protein
chr20_+_21369047 1.54 ENSDART00000090016
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr3_+_22204569 1.54 ENSDART00000055676
ENSDARG00000038186
chr8_-_40287837 1.52 ENSDART00000074125
apelin receptor a
chr23_-_36207526 1.52 ENSDART00000142760
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr25_+_26458700 1.50

chr1_+_13696375 1.48 ENSDART00000103346
FIP1 like 1b (S. cerevisiae)
chr23_-_43396787 1.46

chr7_+_23752492 1.46 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr9_+_22970052 1.45 ENSDART00000143972
replication timing regulatory factor 1
chr16_+_41065107 1.44 ENSDART00000058586
DEK proto-oncogene
chr7_+_71345049 1.43 ENSDART00000165582
structural maintenance of chromosomes flexible hinge domain containing 1
chr24_+_7295201 1.43 ENSDART00000005804
X-ray repair cross complementing 2
chr10_+_21477307 1.42 ENSDART00000064558
eukaryotic translation termination factor 1b
chr22_-_1965842 1.41 ENSDART00000164037
ENSDARG00000103579
chr7_+_13275370 1.39 ENSDART00000020542
pleckstrin homology domain containing, family O member 2
chr6_-_34854950 1.39 ENSDART00000169605
mesoderm induction early response 1a, transcriptional regulator
chr17_-_26519582 1.38 ENSDART00000155692
coiled-coil serine-rich protein 2a
chr2_-_11335644 1.38 ENSDART00000135450
crystallin, zeta (quinone reductase)
chr25_+_26457948 1.37 ENSDART00000153839
zinc finger protein 800a
chr7_-_6328372 1.37 ENSDART00000130760
histone cluster 2 H2A family member b
chr2_-_57826189 1.37 ENSDART00000131420
si:dkeyp-68b7.5
chr7_+_31103149 1.35 ENSDART00000085505
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2b
chr2_-_44924505 1.35 ENSDART00000113351
non-SMC condensin I complex, subunit D2
chr5_+_33949469 1.35 ENSDART00000136787
allograft inflammatory factor 1-like
chr23_-_36207591 1.35 ENSDART00000143340
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr15_+_44160948 1.34 ENSDART00000110060
zgc:165514
chr6_-_37534996 1.34 ENSDART00000147826
jade family PHD finger 3
chr20_-_33584973 1.31 ENSDART00000061843
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr23_+_40517744 1.30 ENSDART00000056328
ELOVL fatty acid elongase 4b
chr20_-_9212139 1.30 ENSDART00000064140
YLP motif containing 1
chr9_-_7235236 1.28 ENSDART00000092435
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_+_37854303 1.26 ENSDART00000143203
poly (ADP-ribose) polymerase 2
chr15_-_17163104 1.25 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr22_-_3986398 1.25 ENSDART00000169317
ENSDART00000171262
ubiquitin-like with PHD and ring finger domains 1
chr5_+_26537518 1.25

chr20_-_33584657 1.25 ENSDART00000061843
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr17_-_26519469 1.22 ENSDART00000155692
coiled-coil serine-rich protein 2a
chr23_+_37476457 1.21 ENSDART00000178064
ENSDARG00000108629
chr19_-_2651862 1.18 ENSDART00000113829
cell division cycle associated 7b
chr23_-_36206989 1.18 ENSDART00000147598
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr22_-_3134699 1.16 ENSDART00000159580
lamin B2
chr8_-_25741931 1.16 ENSDART00000140451
suppressor of variegation 3-9 homolog 1b
chr8_+_20383989 1.16 ENSDART00000009081
MOB kinase activator 3A
chr17_-_26519322 1.15 ENSDART00000122366
coiled-coil serine-rich protein 2a
chr5_-_22466262 1.14 ENSDART00000172549
si:dkey-237j10.2
chr21_-_30750638 1.14 ENSDART00000012091
ribonucleotide reductase M1 polypeptide
chr7_-_37648061 1.14 ENSDART00000052368
HEAT repeat containing 3
chr25_-_13307171 1.14 ENSDART00000056723
GINS complex subunit 3
chr22_-_8144599 1.13 ENSDART00000156571
si:ch73-44m9.3
chr23_+_24672673 1.11 ENSDART00000131689
ENSDART00000078796
KAT8 regulatory NSL complex subunit 2
chr6_+_33946990 1.11 ENSDART00000157397
origin recognition complex, subunit 1
chr22_-_8144696 1.10 ENSDART00000156571
si:ch73-44m9.3
chr16_+_25693740 1.10 ENSDART00000077484
zinc fingers and homeoboxes 2a
chr11_+_44738699 1.10 ENSDART00000172301
ENSDART00000170118
thymidine kinase 1, soluble
chr17_+_18791046 1.09 ENSDART00000130899
si:dkey-288a3.2
chr1_-_46260853 1.08

chr22_-_6916274 1.08

KN150698v1_-_13669 1.08

chr17_+_4167546 1.07 ENSDART00000154264
minichromosome maintenance 8 homologous recombination repair factor
chr1_+_51118765 1.06 ENSDART00000156349
ENSDARG00000096092
chr21_+_26486084 1.06 ENSDART00000134617
adenylosuccinate synthase, like
chr14_-_5100304 1.05 ENSDART00000168074
polycomb group ring finger 1
chr18_-_35152017 1.04

chr22_-_3740362 1.04

chr20_+_44684340 1.04 ENSDART00000149775
ATPase family, AAA domain containing 2B
chr10_-_109097 1.01 ENSDART00000127228
tetratricopeptide repeat domain 3
chr9_+_50341338 1.00

chr7_-_6273677 0.99 ENSDART00000173419
si:ch73-368j24.1
chr23_+_38335290 0.99 ENSDART00000177981
ENSDART00000178842
ENSDARG00000109193
chr25_-_34235633 0.97 ENSDART00000137665
fibroblast growth factor receptor substrate 2b
chr14_+_5921998 0.96 ENSDART00000098346
smu-1 suppressor of mec-8 and unc-52 homolog a (C. elegans)
chr7_-_6328278 0.96 ENSDART00000130760
histone cluster 2 H2A family member b
chr23_+_22052173 0.96 ENSDART00000087110
eukaryotic translation initiation factor 4 gamma, 3b
chr25_-_34235582 0.95 ENSDART00000137665
fibroblast growth factor receptor substrate 2b
chr14_-_16469435 0.94 ENSDART00000113711
zgc:123335
chr22_+_1965847 0.94

chr14_-_15776937 0.94 ENSDART00000165656
MAX dimerization protein 3
chr17_-_22553428 0.93 ENSDART00000079390
exonuclease 1
chr8_+_52429114 0.93 ENSDART00000021604
GINS complex subunit 4 (Sld5 homolog)
chr1_-_22577855 0.92 ENSDART00000175685
replication factor C (activator 1) 1
chr6_-_33946853 0.92 ENSDART00000057290
pre-mRNA processing factor 38A
chr8_+_53734037 0.92 ENSDART00000179055
ENSDARG00000106018
chr20_-_33584691 0.92 ENSDART00000061843
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
KN150589v1_-_5247 0.91 ENSDART00000157761
ENSDART00000157531
ELOVL fatty acid elongase 7b
chr5_-_32655521 0.91 ENSDART00000085531
protein kinase, AMP-activated, alpha 1 catalytic subunit
chr2_-_29939814 0.91 ENSDART00000031130
PAX interacting (with transcription-activation domain) protein 1
chr2_+_5383347 0.91 ENSDART00000019925
G protein subunit beta 4
chr8_+_30103357 0.90 ENSDART00000133717
Fanconi anemia, complementation group C
chr11_-_25223169 0.89

chr25_+_11212787 0.89 ENSDART00000159583
ENSDARG00000099473
chr17_+_26809555 0.89 ENSDART00000136971
jade family PHD finger 1
chr19_-_20819057 0.88 ENSDART00000136826
deleted in azoospermia-like
chr21_-_30371822 0.88 ENSDART00000138384
NHP2 ribonucleoprotein homolog (yeast)
chr11_-_25223110 0.87

chr24_+_17201072 0.86 ENSDART00000024722
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr2_+_11335733 0.86 ENSDART00000055737
tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
chr10_+_21477806 0.85 ENSDART00000142447
eukaryotic translation termination factor 1b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
2.1 10.4 GO:1902103 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
2.0 14.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.6 6.2 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
1.3 6.4 GO:0060967 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
1.2 3.6 GO:0034421 post-translational protein acetylation(GO:0034421)
1.0 5.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
1.0 3.1 GO:0000076 DNA replication checkpoint(GO:0000076)
1.0 12.1 GO:0044030 regulation of DNA methylation(GO:0044030)
0.8 0.8 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.8 3.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.7 3.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.6 2.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.5 2.6 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of calcium ion transport into cytosol(GO:0010524) positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904323) positive regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904325)
0.5 1.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 1.8 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.4 1.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.4 2.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 4.5 GO:0030719 P granule organization(GO:0030719)
0.4 2.0 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.4 1.1 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.3 2.1 GO:0008210 estrogen biosynthetic process(GO:0006703) estrogen metabolic process(GO:0008210)
0.3 4.7 GO:0097178 ruffle assembly(GO:0097178)
0.3 1.7 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.3 1.2 GO:0030728 ovulation(GO:0030728)
0.3 1.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 0.8 GO:0043116 negative regulation of vascular permeability(GO:0043116) negative regulation of calcium ion import(GO:0090281)
0.2 0.7 GO:0061511 centriole elongation(GO:0061511)
0.2 0.7 GO:0042126 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
0.2 0.9 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.2 1.7 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 3.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 0.6 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.2 0.9 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 5.0 GO:2000779 regulation of double-strand break repair(GO:2000779)
0.2 0.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.7 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 2.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.9 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.1 2.7 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.1 1.9 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.1 2.2 GO:0006298 mismatch repair(GO:0006298)
0.1 3.8 GO:0000723 telomere maintenance(GO:0000723) telomere organization(GO:0032200)
0.1 0.4 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.1 2.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.1 0.8 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 0.7 GO:0003232 bulbus arteriosus development(GO:0003232) negative regulation of histone methylation(GO:0031061)
0.1 5.1 GO:0034968 histone lysine methylation(GO:0034968)
0.1 0.6 GO:1902946 protein localization to early endosome(GO:1902946)
0.1 3.5 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.3 GO:0098900 regulation of action potential(GO:0098900)
0.1 1.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.3 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.1 0.3 GO:0043985 histone arginine methylation(GO:0034969) histone H4-R3 methylation(GO:0043985)
0.1 0.8 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.1 0.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.4 GO:0043650 dicarboxylic acid biosynthetic process(GO:0043650)
0.0 0.5 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 2.6 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 1.1 GO:0071897 DNA biosynthetic process(GO:0071897)
0.0 0.4 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 1.0 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.2 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.8 GO:0000077 DNA damage checkpoint(GO:0000077)
0.0 1.1 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.6 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 6.2 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.0 1.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.6 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 1.6 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 1.4 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.5 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 1.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0032615 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.0 0.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.1 GO:0030299 intestinal cholesterol absorption(GO:0030299) lipid digestion(GO:0044241)
0.0 0.9 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.1 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.9 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 1.7 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.1 GO:0008334 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) histone mRNA metabolic process(GO:0008334)
0.0 0.4 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.5 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.6 GO:0045010 actin nucleation(GO:0045010)
0.0 1.8 GO:0006457 protein folding(GO:0006457)
0.0 0.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.4 GO:0008203 cholesterol metabolic process(GO:0008203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0033391 chromatoid body(GO:0033391)
1.0 5.2 GO:0018444 translation release factor complex(GO:0018444)
1.0 3.1 GO:0031298 replication fork protection complex(GO:0031298)
0.6 1.8 GO:0061574 ASAP complex(GO:0061574)
0.6 3.9 GO:0035101 FACT complex(GO:0035101)
0.5 2.9 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.4 3.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 1.7 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.3 1.9 GO:0070187 telosome(GO:0070187)
0.2 1.9 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.2 5.1 GO:0032587 ruffle membrane(GO:0032587)
0.2 0.9 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 1.7 GO:0030904 retromer complex(GO:0030904)
0.1 1.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.5 GO:0000796 condensin complex(GO:0000796)
0.1 0.3 GO:0044304 main axon(GO:0044304)
0.1 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.3 GO:0000792 heterochromatin(GO:0000792)
0.1 0.3 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 1.4 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 0.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 5.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 0.7 GO:0070847 core mediator complex(GO:0070847)
0.1 2.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.1 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.0 1.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 7.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 7.4 GO:0005730 nucleolus(GO:0005730)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 1.4 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 2.3 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
1.7 5.2 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.7 5.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.7 3.6 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.7 2.8 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.6 6.4 GO:0008494 translation activator activity(GO:0008494)
0.6 4.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 1.6 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.4 1.7 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.4 2.6 GO:0060182 apelin receptor activity(GO:0060182)
0.4 1.7 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.4 7.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 0.7 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.3 1.7 GO:0009374 biotin binding(GO:0009374)
0.3 2.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.3 1.1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.3 2.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 0.7 GO:0046857 nitrite reductase [NAD(P)H] activity(GO:0008942) oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor(GO:0046857)
0.2 2.3 GO:0070403 NAD+ binding(GO:0070403)
0.2 0.9 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.4 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.1 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 1.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 2.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.3 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.6 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 1.9 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 1.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 4.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.5 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 2.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 19.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 11.8 GO:0016887 ATPase activity(GO:0016887)
0.0 2.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 8.9 GO:0051015 actin filament binding(GO:0051015)
0.0 0.0 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.7 GO:0031386 protein tag(GO:0031386)
0.0 2.7 GO:0016407 acetyltransferase activity(GO:0016407)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 2.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.9 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.8 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 2.4 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 6.0 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.1 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.3 11.6 PID ATR PATHWAY ATR signaling pathway
0.2 8.6 PID AURORA B PATHWAY Aurora B signaling
0.2 1.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 9.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 5.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 3.7 PID P53 REGULATION PATHWAY p53 pathway
0.1 1.9 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID FAS PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 21.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.1 11.8 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.4 4.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 0.9 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 3.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 3.9 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 2.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 2.0 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.1 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation