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Results for e2f7_e2f1
Z-value: 2.85
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Transcription factors associated with e2f7_e2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f7 | dr10_dc_chr4_-_2615160_2615257 | -0.67 | 4.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f7_e2f1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_14308032 Show fit | 11.66 |
|
|
|
| chr23_-_18131502 Show fit | 10.91 |
ENSDART00000173075
|
zgc:92287 |
|
| chr19_+_41419851 Show fit | 9.91 |
ENSDART00000138555
ENSDART00000158587 ENSDART00000049842 |
CAS1 domain containing 1 |
|
| chr22_-_38321005 Show fit | 9.57 |
ENSDART00000015117
|
ELAV like neuron-specific RNA binding protein 2 |
|
| chr12_+_47448318 Show fit | 8.95 |
ENSDART00000152857
|
formin 2b |
|
| chr19_-_48731766 Show fit | 7.43 |
ENSDART00000170726
|
si:ch73-359m17.2 |
|
| chr5_-_22466262 Show fit | 7.16 |
ENSDART00000172549
|
si:dkey-237j10.2 |
|
| chr5_+_23543441 Show fit | 6.86 |
ENSDART00000174856
|
CTD nuclear envelope phosphatase 1a |
|
| chr25_+_20174490 Show fit | 6.63 |
ENSDART00000109605
|
si:dkey-219c3.2 |
|
| chr7_+_31103149 Show fit | 6.62 |
ENSDART00000085505
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2b |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.8 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 1.1 | 11.3 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 1.8 | 9.2 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.2 | 9.0 | GO:0045010 | actin nucleation(GO:0045010) |
| 1.8 | 8.9 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 1.3 | 8.8 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.3 | 8.1 | GO:0007040 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 1.2 | 7.0 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.7 | 6.7 | GO:0097341 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 0.1 | 6.7 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.5 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.6 | 12.8 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.4 | 11.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.5 | 10.5 | GO:0043186 | P granule(GO:0043186) |
| 0.4 | 10.2 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.8 | 10.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 9.0 | GO:0005884 | actin filament(GO:0005884) |
| 1.3 | 8.8 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 7.3 | GO:0016604 | nuclear body(GO:0016604) |
| 0.4 | 5.6 | GO:0000782 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.2 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.1 | 19.4 | GO:0042393 | histone binding(GO:0042393) |
| 1.1 | 13.8 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.2 | 13.0 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.1 | 10.7 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 10.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.0 | 8.9 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.2 | 8.1 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.2 | 7.1 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.7 | 6.7 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 3.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 1.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 1.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.6 | 6.0 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 5.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 3.6 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.4 | 3.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 3.0 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 2.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.6 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.2 | 2.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 2.4 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |