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Results for e4f1

Z-value: 0.68

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Transcription factors associated with e4f1

Gene Symbol Gene ID Gene Info
e4f1
ENSDARG00000038243 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e4f1dr10_dc_chr3_-_18587352_185874550.802.2e-04Click!

Activity profile of e4f1 motif

Sorted Z-values of e4f1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of e4f1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_44539778 2.31 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr16_-_41585481 1.39 ENSDART00000102662
rpp25l
ribonuclease P/MRP 25 subunit-like
chr5_-_28931727 1.35 ENSDART00000174697
arrdc1a
arrestin domain containing 1a
chr3_+_33608070 1.28

chr15_-_23786063 1.18 ENSDART00000109318
zc3h4
zinc finger CCCH-type containing 4
chr25_+_34340569 1.15 ENSDART00000157638
tmem231
transmembrane protein 231
chr20_-_44678938 1.15 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr2_-_19705537 1.05 ENSDART00000168627
zfyve9a
zinc finger, FYVE domain containing 9a
chr19_+_43090603 1.04 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr1_-_54488824 0.96 ENSDART00000150430
pane1
proliferation associated nuclear element
chr16_-_13723352 0.95 ENSDART00000139102
dbpb
D site albumin promoter binding protein b
chr19_-_44459352 0.90 ENSDART00000151084
uqcrb
ubiquinol-cytochrome c reductase binding protein
chr9_+_33523707 0.90 ENSDART00000171649
ddx3a
DEAD (Asp-Glu-Ala-Asp) box helicase 3a
chr2_+_9762781 0.89 ENSDART00000003465
gipc2
GIPC PDZ domain containing family, member 2
chr20_+_16740320 0.88 ENSDART00000152359
tmem30ab
transmembrane protein 30Ab
chr4_+_1873500 0.83 ENSDART00000021139
fgfr1op2
FGFR1 oncogene partner 2
chr22_-_26971170 0.83 ENSDART00000162742
ENSDARG00000061256
ENSDARG00000061256
chr18_+_6417959 0.82 ENSDART00000110892
b4galnt3b
beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr25_+_30627892 0.80

chr25_+_30627755 0.78

chr4_+_9010972 0.76 ENSDART00000058007
samm50l
sorting and assembly machinery component 50 homolog, like
chr13_-_7972442 0.72 ENSDART00000128005
atl2
atlastin GTPase 2
chr22_-_510040 0.70 ENSDART00000140101
ccnd3
cyclin D3
chr19_+_43090664 0.70 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr5_+_71360249 0.68

chr8_-_19236074 0.68 ENSDART00000137994
zgc:77486
zgc:77486
chr23_-_30837726 0.68 ENSDART00000075918
pcmtd2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr23_+_17583383 0.67 ENSDART00000148457
gid8b
GID complex subunit 8 homolog b (S. cerevisiae)
chr2_+_9762627 0.67 ENSDART00000003465
gipc2
GIPC PDZ domain containing family, member 2
chr2_-_4191540 0.66 ENSDART00000158335
rab18b
RAB18B, member RAS oncogene family
chr3_-_15337208 0.65 ENSDART00000011320
nfatc2ip
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr7_-_24722804 0.65

chr17_+_25168837 0.65 ENSDART00000148431
cln8
CLN8, transmembrane ER and ERGIC protein
chr23_-_20199769 0.64 ENSDART00000147725
tktb
transketolase b
chr23_+_17583666 0.64 ENSDART00000054738
gid8b
GID complex subunit 8 homolog b (S. cerevisiae)
chr8_-_19235896 0.64 ENSDART00000036148
zgc:77486
zgc:77486
chr13_-_7972530 0.64 ENSDART00000080460
atl2
atlastin GTPase 2
chr3_-_21006698 0.63 ENSDART00000104051
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr7_+_66410533 0.62 ENSDART00000027616
ENSDART00000162763
eif4g2a
eukaryotic translation initiation factor 4, gamma 2a
chr16_-_13723295 0.61 ENSDART00000139102
dbpb
D site albumin promoter binding protein b
chr10_+_14530451 0.61 ENSDART00000026383
sigmar1
sigma non-opioid intracellular receptor 1
chr12_+_33793663 0.61 ENSDART00000004769
mfsd13a
major facilitator superfamily domain containing 13A
chr19_+_43090486 0.59 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr12_+_48295188 0.59 ENSDART00000164427
ndr2
nodal-related 2
chr17_-_31195299 0.58 ENSDART00000086511
rpusd2
RNA pseudouridylate synthase domain containing 2
KN150065v1_-_622 0.58

chr16_-_41585555 0.57 ENSDART00000131706
rpp25l
ribonuclease P/MRP 25 subunit-like
KN150030v1_-_22613 0.56 ENSDART00000175410
CABZ01079802.1
ENSDARG00000106760
chr13_-_36312975 0.56 ENSDART00000084867
dcaf5
ddb1 and cul4 associated factor 5
chr24_-_37438115 0.56 ENSDART00000003789
pdpk1b
3-phosphoinositide dependent protein kinase 1b
chr2_-_6380292 0.56 ENSDART00000092182
ppm1la
protein phosphatase, Mg2+/Mn2+ dependent, 1La
chr12_+_33793468 0.55 ENSDART00000130853
mfsd13a
major facilitator superfamily domain containing 13A
chr16_+_26858575 0.55 ENSDART00000138496
rad54b
RAD54 homolog B (S. cerevisiae)
chr12_-_926596 0.53 ENSDART00000088351
SPAG9 (1 of many)
sperm associated antigen 9
KN150075v1_-_7761 0.53 ENSDART00000163569
ENSDART00000166885
CABZ01094849.1
ENSDARG00000103185
chr7_+_66410947 0.51 ENSDART00000027616
ENSDART00000162763
eif4g2a
eukaryotic translation initiation factor 4, gamma 2a
chr17_-_31195376 0.51 ENSDART00000086511
rpusd2
RNA pseudouridylate synthase domain containing 2
chr10_-_2944190 0.51 ENSDART00000132526
marveld2a
MARVEL domain containing 2a
chr16_-_13723778 0.51 ENSDART00000139102
dbpb
D site albumin promoter binding protein b
chr4_-_26046562 0.51 ENSDART00000124514
usp44
ubiquitin specific peptidase 44
chr22_-_10511906 0.48 ENSDART00000013933
si:dkey-42i9.4
si:dkey-42i9.4
chr6_+_94581 0.47 ENSDART00000125176
ap1m2
adaptor-related protein complex 1, mu 2 subunit
chr11_-_44539726 0.46 ENSDART00000173360
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr23_-_30837755 0.45 ENSDART00000075918
pcmtd2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr10_-_2944295 0.45 ENSDART00000132526
marveld2a
MARVEL domain containing 2a
chr21_-_9689702 0.45 ENSDART00000158836
arhgap24
Rho GTPase activating protein 24
chr8_-_19235793 0.44 ENSDART00000036148
zgc:77486
zgc:77486
chr20_-_36768780 0.44 ENSDART00000134819
slc5a6a
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6a
chr25_-_34340016 0.44 ENSDART00000039485
gabarapl2
GABA(A) receptor-associated protein like 2
chr20_-_36768848 0.44 ENSDART00000134819
slc5a6a
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6a
chr15_-_23786239 0.43 ENSDART00000109318
zc3h4
zinc finger CCCH-type containing 4
chr12_+_33219727 0.43 ENSDART00000021491
csnk1db
casein kinase 1, delta b
chr13_+_17333378 0.42 ENSDART00000139245
CT025897.1
ENSDARG00000093577
chr4_-_12931110 0.42 ENSDART00000013604
lemd3
LEM domain containing 3
chr23_+_17583294 0.40 ENSDART00000148457
gid8b
GID complex subunit 8 homolog b (S. cerevisiae)
chr2_+_56045684 0.38 ENSDART00000021011
upf1
upf1 regulator of nonsense transcripts homolog (yeast)
chr9_+_52308527 0.38

chr14_-_38606412 0.37 ENSDART00000139293
gla
galactosidase, alpha
chr16_+_26858600 0.36 ENSDART00000138496
rad54b
RAD54 homolog B (S. cerevisiae)
chr14_+_30073402 0.36 ENSDART00000136009
cnot7
CCR4-NOT transcription complex, subunit 7
chr23_-_30837818 0.35 ENSDART00000075918
pcmtd2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
KN150213v1_-_1975 0.34

chr6_+_59580339 0.33

chr16_-_4940519 0.33 ENSDART00000149421
rpa2
replication protein A2
chr24_-_37438357 0.33 ENSDART00000003789
pdpk1b
3-phosphoinositide dependent protein kinase 1b
chr12_+_48295296 0.32 ENSDART00000164427
ndr2
nodal-related 2
chr13_-_17333382 0.30 ENSDART00000145499
c13h10orf11
c13h10orf11 homolog (H. sapiens)
chr17_+_8596825 0.30 ENSDART00000105322
edrf1
erythroid differentiation regulatory factor 1
chr4_+_1873543 0.30 ENSDART00000021139
ENSDART00000144356
fgfr1op2
FGFR1 oncogene partner 2
chr23_-_30837699 0.29 ENSDART00000075918
pcmtd2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr23_+_2105366 0.28

chr22_-_4375781 0.28 ENSDART00000081969
rad23ab
RAD23 homolog A, nucleotide excision repair protein b
chr13_-_17333287 0.28 ENSDART00000145499
c13h10orf11
c13h10orf11 homolog (H. sapiens)
chr15_-_34799968 0.28 ENSDART00000110964
bag6
BCL2-associated athanogene 6
chr15_+_20303539 0.27 ENSDART00000152473
spint2
serine peptidase inhibitor, Kunitz type, 2
chr24_-_37438154 0.26 ENSDART00000003789
pdpk1b
3-phosphoinositide dependent protein kinase 1b
chr1_-_54488896 0.26 ENSDART00000150430
pane1
proliferation associated nuclear element
chr20_+_36909452 0.24 ENSDART00000062931
abracl
ABRA C-terminal like
chr15_-_1880173 0.24 ENSDART00000154175
taf15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_7127672 0.23 ENSDART00000050597
xpr1b
xenotropic and polytropic retrovirus receptor 1b
chr10_+_23130414 0.23 ENSDART00000022170
LTN1
listerin E3 ubiquitin protein ligase 1
chr13_-_36313037 0.22 ENSDART00000084867
dcaf5
ddb1 and cul4 associated factor 5
chr5_+_35839198 0.22 ENSDART00000102973
ENSDART00000103020
eda
ectodysplasin A
chr14_+_31278635 0.21 ENSDART00000158875
ENSDART00000026195
slc9a6a
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6a
chr7_-_26246798 0.21 ENSDART00000058913
eif4a1a
eukaryotic translation initiation factor 4A1A
chr21_-_1956120 0.20 ENSDART00000165547
CABZ01045062.1
ENSDARG00000100274
chr19_-_46631565 0.20

chr3_+_60988788 0.19 ENSDART00000110030
lmtk2
lemur tyrosine kinase 2
chr5_+_36250811 0.18 ENSDART00000051186
nccrp1
non-specific cytotoxic cell receptor protein 1
chr15_+_20303673 0.17 ENSDART00000152473
spint2
serine peptidase inhibitor, Kunitz type, 2
chr15_-_1880375 0.17 ENSDART00000102410
taf15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr12_+_33219444 0.17 ENSDART00000021491
csnk1db
casein kinase 1, delta b
chr11_-_17648202 0.17 ENSDART00000080770
tmf1
TATA element modulatory factor 1
chr23_-_20199837 0.17 ENSDART00000005021
tktb
transketolase b
chr17_-_9839620 0.17 ENSDART00000148463
snx6
sorting nexin 6
chr15_+_20303330 0.17 ENSDART00000152473
spint2
serine peptidase inhibitor, Kunitz type, 2
chr17_-_32668462 0.15 ENSDART00000155321
CU019637.1
ENSDARG00000097530
chr25_+_35540123 0.14 ENSDART00000126326
rpgrip1l
RPGRIP1-like
chr4_-_12930797 0.14 ENSDART00000108552
lemd3
LEM domain containing 3
chr21_-_1956163 0.14 ENSDART00000165547
CABZ01045062.1
ENSDARG00000100274
chr2_+_56045488 0.13 ENSDART00000021011
upf1
upf1 regulator of nonsense transcripts homolog (yeast)
chr6_-_57542175 0.13 ENSDART00000156967
itcha
itchy E3 ubiquitin protein ligase a
chr23_-_5825177 0.12 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr2_-_19705322 0.09 ENSDART00000168627
zfyve9a
zinc finger, FYVE domain containing 9a
chr10_+_45056951 0.08 ENSDART00000158553
ENSDARG00000101143
ENSDARG00000101143
chr1_-_22905093 0.07 ENSDART00000138852
lcorl
ligand dependent nuclear receptor corepressor-like
chr5_-_57045042 0.04 ENSDART00000141630
si:dkey-71l1.1
si:dkey-71l1.1
chr10_-_44170848 0.04 ENSDART00000135240
acads
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr11_+_2641147 0.03 ENSDART00000132768
mapk14b
mitogen-activated protein kinase 14b
chr18_+_6898118 0.01 ENSDART00000018735
dnaja2l
DnaJ (Hsp40) homolog, subfamily A, member 2, like
chr19_+_20579471 0.00 ENSDART00000090942
ccdc126
coiled-coil domain containing 126

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0030730 regulation of sequestering of triglyceride(GO:0010889) positive regulation of sequestering of triglyceride(GO:0010890) sequestering of triglyceride(GO:0030730)
0.3 1.1 GO:0072574 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.2 2.0 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 0.7 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.2 0.9 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.2 3.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.1 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 0.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.7 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.9 GO:0001709 cell fate determination(GO:0001709)
0.1 1.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.5 GO:1904666 regulation of ubiquitin protein ligase activity(GO:1904666)
0.1 0.4 GO:0035313 negative regulation of Rac protein signal transduction(GO:0035021) wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 0.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.7 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 0.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 0.4 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 1.4 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 2.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.6 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.4 GO:1900151 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.2 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.9 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.6 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 0.6 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.3 GO:0006413 translational initiation(GO:0006413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0061689 tricellular tight junction(GO:0061689)
0.3 2.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 3.2 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.7 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.1 2.4 GO:0005811 lipid particle(GO:0005811)
0.1 1.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.6 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.2 GO:0000775 chromosome, centromeric region(GO:0000775)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.2 0.9 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 0.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.2 0.6 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.2 0.9 GO:0070698 type I activin receptor binding(GO:0070698)
0.2 0.9 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.6 GO:0046625 sphingolipid binding(GO:0046625) ceramide binding(GO:0097001)
0.1 1.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.4 GO:0015925 galactosidase activity(GO:0015925)
0.0 3.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism